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Author manuscript; available in PMC 2025 June 01. |\n| --- | --- |\n\nPublished in final edited form as:  \nMed Image Anal. 2025 May ; 102: [103531. doi:10.1016/j.media.2025.103531](103531. doi:10.1016/j.media.2025.103531) .  \nSpinFlowSim: A blood flow simulation framework for histologyinformed diffusion MRI microvasculature mapping in cancer  \nAnna Kira Voronovaa,b, Athanasios Grigorioua,b, Kinga Bernatowicza, Sara Simonettia, Garazi Sernaa, Núria Rosonc,d, Manuel Escobarc,d, Maria Vieitoe, Paolo Nuciforoa, Rodrigo Toledoa, Elena Garraldae, Els Fieremansf, Dmitry S. Novikovf, Marco Palombog,h, Raquel Perez-Lopeza,*,1 , Francesco Grussua,*,1  \naVall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain  \nb Department of Biomedicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain  \nc Institut de Diagnòstic per la Imatge (IDI), Barcelona, Spain  \nThis is an open access article under the CC BY-NC license ([http://creativecommons.org/licenses/by-nc/4.0/](http://creativecommons.org/licenses/by-nc/4.0/)).  \n*Correspondence to: VHIO, Carrer de Saturnino Calleja 11-13, 08035 Barcelona, Spain., [rperez@vhio.net](rperez@vhio.net) (R. Perez-Lopez), f1grEussuqualvhiontrib.neutito(Fn(.jGruointsssn) .ior authors) .  \nDeclaration of competing interest  \nThe authors declare the following financial interests/personal relationships which may be considered as potential competing interests: RPL reports financial support was provided by Agencia Estatal de Investigación. RPL reports financial support was provided by Cellex Foundation. RPL reports financial support was provided by CERCA Programme from the Generalitat de Catalunya.  \nRPL reports financial support was provided by AstraZeneca. RPL reports financial support was provided by European Regional Development Fund. EG reports financial support was provided by Banco Bilbao Vizcaya Argentaria Foundation Foundation. RPL reports financial support was provided by LaCaixa Foundation. FG reports financial support was provided by LaCaixa Foundation. RPL reports financial support was provided by Prostate Cancer Foundation. RPL reports financial support was provided by CRIS Cancer Foundation. RPL reports was provided by Fero Foundation. RPL reports financial support was provided by Carlos III Health Institute. RPL reports financial support was provided by Spanish Association Against Cancer Scientific Foundation. RPL reports financial support was provided by Government of Catalonia Agency for Administration of University and Research Grants. KB reports financial support was provided by Government of Catalonia Agency for Administration of University and Research Grants. MP reports financial support was provided by UK Research and Innovation. AG reports financial support was provided by Agencia Estatal de Investigación. This study has received support by AstraZeneca. K.B. was a researcher at VHIO (Barcelona, Spain), and is now an employee of AstraZeneca (Barcelona, Spain). AstraZeneca was not involved in the acquisition and analysis of the data, interpretation of the results, or the decision to submit this article for publication in its current form. All other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Appendix A. Supplementary data  \nSupplementary material related to this article can be found online at [https://doi.org/10.1016/j.media.2025.103531](https://doi.org/10.1016/j.media.2025.103531) .  \nCRediT authorship contribution statement  \nAnna Kira Voronova: Writing – review & editing, Writing – original draft, Visualization, Validation, Software, Resources, Project administration, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Athanasios Gri","cbCaic9Gk2QvYdE2","https://ap.wps.com/l/cbCaic9Gk2QvYdE2","pdf",3708795,42,"English","# Published details\n## Open access and licensing\n## Supplementary data\n## Competing interests\n## CRediT authorship contribution statement","[{\"question\":\"What is SpinFlowSim intended to do?\",\"answer\":\"SpinFlowSim is a blood flow simulation framework aimed at histology-informed diffusion MRI microvasculature mapping in cancer.\"},{\"question\":\"Where is the manuscript published and what is the publication status?\",\"answer\":\"The work is published in Med Image Analysis in 2025 and is available as an open-access author manuscript in PMC.\"},{\"question\":\"Does the manuscript include information about conflicts of interest and funding?\",\"answer\":\"Yes. It contains a declaration of competing interests and extensive statements about financial support from multiple organizations and programs.\"}]","SpinFlowSim - A blood flow simulation framework for histology-informed diffusion MRI microvasculature mapping in cancer | PDF",1790160664,106]