[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-407371-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-407371-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","specificity-of-endothelial-cells-in-endothelial-dysfunction-of-diabetic-kidney-disease-and-their-crosstalk-with-neighboring-cells-an-updated-review","Specificity of endothelial cells in endothelial dysfunction of diabetic kidney disease and their crosstalk with neighboring cells - an updated review","","Diabetic kidney disease (DKD) is a major diabetic microvascular complication marked by persistent proteinuria, reduced glomerular filtration rate, and progressive pathological changes leading to end-stage renal disease. Renal endothelial cell homeostasis supports glomerular structure and function through anti-inflammatory and antithrombotic control while limiting fibrosis. Although intrinsic renal injury is widely studied, the distinct roles of glomerular endothelial cells in endothelial dysfunction and their communication with neighboring cells are less defined. This review synthesizes evidence on glomerular endothelial cell phenotypic heterogeneity, early glycocalyx damage, late fibrosis, and dynamic crosstalk with podocytes, mesangial cells, and tubular epithelial cells, plus endothelial-targeted therapeutic strategies.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/specificity-of-endothelial-cells-in-endothelial-dysfunction-of-diabetic-kidney-disease-and-their-crosstalk-with-neighboring-cells-an-updated-review/407371/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/specificity-of-endothelial-cells-in-endothelial-dysfunction-of-diabetic-kidney-disease-and-their-crosstalk-with-neighboring-cells-an-updated-review/407371.png","ImageObject",300,407,{"name":42,"@type":43},"River Wang","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the role of glomerular endothelial cells in DKD?","Question",{"text":63,"@type":64},"Glomerular endothelial cells maintain glomerular architecture and homeostasis and are vulnerable to hyperglycemia and circulating metabolites. Their dysfunction contributes to DKD initiation and progression.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How does endothelial glycocalyx damage relate to DKD?",{"text":68,"@type":64},"Endothelial surface layer degradation is highlighted as an early marker of diabetic microvascular injury, associated with increased vascular permeability and downstream pathological changes.",{"name":70,"@type":61,"acceptedAnswer":71},"Which neighboring cell types does the review emphasize in endothelial crosstalk?",{"text":72,"@type":64},"The review focuses on dynamic interactions between glomerular endothelial cells and podocytes, mesangial cells, and tubular epithelial cells to explain disease progression and barrier integrity changes.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},407371,1790716559,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":108,"preview_page_count":4},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","TYPE Review  \nPUBLISHED 17 December 2025 DOI 10.3389/fendo.2025.1742296  \nOPEN ACCESS  \nEDITED BY  \nSwaran J. S. Flora,  \nNational Institute of Pharmaceutical Education and Research, India  \nREVIEWED BY  \nRaushan Kumar,  \nERA ’s Lucknow Medical College, India Soumik Das,  \nVellore Institute of Technology, India  \n*CORRESPONDENCE  \nMin Li  \n [min_li2025@163.com](min_li2025@163.com)  \n†These authors have contributed equally to this work and share first authorship  \nRECEIVED 08 November 2025  \nREVISED 28 November 2025  \nACCEPTED 05 December 2025  \nPUBLISHED 17 December 2025  \nCITATION  \nLi J, Zhang Y, Sun X, Guan H, Wang J, Zhao S, Tian C, Han M, Ma K and Li M (2025)  \nSpecificity of endothelial cells in endothelial dysfunction of diabetic kidney disease and their crosstalk with neighboring cells: an updated review.  \nFront. Endocrinol. 16:1742296 .  \ndoi: 10.3389/fendo.2025.1742296  \nCOPYRIGHT  \n© 2025 Li, Zhang, Sun, Guan, Wang, Zhao, Tian, Han, Ma and Li. This is an open-access article distributed under the terms of the  \nCreative Commons Attribution License (CC BY) .  \nThe use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nSpecificity of endothelial cells in endothelial dysfunction of diabetic kidney disease and their crosstalk with neighboring cells: an updated review  \nJiarui Li 1†, Yue Zhang 1†, Xiao Sun 2†, Huifang Guan 1, Jingshuo Wang 3, Shuang Zhao 1, Chuanxi Tian 2, Mingda Han 1, Kaile Ma 4 and Min Li 4*  \n1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China, 2Guang’ anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, China, 3The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China, 4 Research Laboratory of Molecular Biology, Guang’anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, China  \nDiabetic kidney disease (DKD), a major microvascular complication of diabetes, is characterized by persistent proteinuria, a declining glomerular filtration rate (GFR), and distinctive pathological alterations, often progressing to end-stage renal disease (ESRD) . Renal endothelial cells homeostasis is essential for maintaining glomerular architecture and function, sustaining an antiinflammatory and antithrombotic environment, and preventing fibrosis. Although injury to intrinsic renal cells has been widely studied, the distinct contribution of glomerular endothelial cells (GECs) to endothelial dysfunction and their crosstalk with neighboring cells remain poorly defined. Crosstalk between renal cells is critical for integrity of the glomerular filtration barrier (GFB) and overall renal homeostasis. This review provides an updated and systematic overview of the distinct roles of GECs in DKD, encompassing their phenotypic heterogeneity, early glycocalyx damage with increased vascular permeability, and late-stage renal fibrosis. It further elaborates on the dynamic interactions between GECs and podocytes, mesangial cells (MCs), and tubular epithelial cells (TECs) . Additionally, we summarize therapeutic strategies targeting endothelial function in DKD, including direct anti-hyperglycemic interventions, non-glycemic interventions, and approaches focused on endothelial injury biomarkers. In summary, this review highlights the distinct and underappreciated role of endothelial cells in DKD, emphasizing their therapeutic potential as a primary target.  \nKEYWORDS  \ncell communication, DKD, endothelial dysfunction, glomerular endothelial cells, mesangial cells, podocytes, tubular epithelial cells  \nFrontiers in Endocrinology 01 [frontiersin.org](frontiersin.org)  \n1 Introduction  \nDiabetic kidney disease (DKD) is one of ","cbCaimthKsJBXjxw","https://ap.wps.com/l/cbCaimthKsJBXjxw","pdf",2513944,16,"English","# Introduction\n## Diabetic kidney disease and early endothelial injury\n# Mechanisms of hyperglycemia-induced endothelial dysfunction\n## Molecular regulation, inflammation, oxidative stress, and adhesion molecules\n## Angiogenesis dysregulation in DKD","[{\"question\":\"What is the role of glomerular endothelial cells in DKD?\",\"answer\":\"Glomerular endothelial cells maintain glomerular architecture and homeostasis and are vulnerable to hyperglycemia and circulating metabolites. Their dysfunction contributes to DKD initiation and progression.\"},{\"question\":\"How does endothelial glycocalyx damage relate to DKD?\",\"answer\":\"Endothelial surface layer degradation is highlighted as an early marker of diabetic microvascular injury, associated with increased vascular permeability and downstream pathological changes.\"},{\"question\":\"Which neighboring cell types does the review emphasize in endothelial crosstalk?\",\"answer\":\"The review focuses on dynamic interactions between glomerular endothelial cells and podocytes, mesangial cells, and tubular epithelial cells to explain disease progression and barrier integrity changes.\"}]","Specificity of endothelial cells in endothelial dysfunction of diabetic kidney disease and their crosstalk with neighboring cells - an updated review | PDF",1790573423]