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Screening cannabinoid libraries identified molecular selectivity among specific compounds that reversed the metastatic immune-escape phenotype in vitro by inducing MHC-I surface expression. Cannabigerol and gamma interferon produced overlapping epigenetic programs and activated senescence- and APM-related gene pathways, suggesting potential utility for cancer immunotherapy 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and APM genes tied to adaptive immune recognition.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},377654,1790318433,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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10.3389/fimmu.2022.982082  \nOPEN ACCESS  \nEDITED BY  \nAdriana Albini,  \nMultiMedica Holding SpA (IRCCS), Italy  \nREVIEWED BY  \nBruno Miguel Fonseca, University of Porto, Portugal Douglas Mc Clain Noonan, University of Insubria, Italy  \n*CORRESPONDENCE Wilfred A. Jefferies  \n [wilf@msl.ubc.ca](wilf@msl.ubc.ca)  \n†PRESENT ADDRESSES Sarah Dada,  \nMichael Smith Genome Sciences Centre, Vancouver, BC, Canada;  \nBioinformatics Graduate Program, Faculty of Science, University of British Columbia, Vancouver, BC, Canada  \n‡These authors share first authorship  \nSPECIALTY SECTION  \nThis article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Immunology  \nRECEIVED 30 June 2022  \nACCEPTED 20 December 2022  \nPUBLISHED 22 February 2023  \nCITATION  \nDada S, Ellis SLS, Wood C, Nohara LL, Dreier C, Garcia NH, Saranchova I, Munro L, Pfeifer CG, Eyford BA, Kari S, Garrovillas E, Caspani G, Al Haddad E, Gray PW, Morova T, Lack NA, Andersen RJ, Tjoelker L and Jefferies WA (2023) Specificcannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours.  \nFront. Immunol. 13:982082 .  \ndoi: 10.3389/fimmu.2022.982082  \nCOPYRIGHT  \n© 2023 Dada, Ellis, Wood, Nohara, Dreier, Garcia, Saranchova, Munro, Pfeifer, Eyford, Kari, Garrovillas, Caspani, Al Haddad, Gray, Morova, Lack, Andersen, Tjoelker and Jefferies. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nSpecific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours  \nSarah Dada 1,2,3,4,5†‡, Samantha L. S. Ellis 1,2,3,4,6‡, Christi Wood 7, Lilian L. Nohara 1,3,4,5, Carola Dreier 1,3,4,5,7, Nicolas H. Garcia 8, Iryna Saranchova 1,2,3,4, Lonna Munro 1,2,3,4, Cheryl G. Pfeifer 1,2,3,4, Brett A. Eyford 1,3,4, Suresh Kari 1,2,3,4, Emmanuel Garrovillas 1,2,3,4,5,6, Giorgia Caspani 1,2,3,4,5,6, Eliana Al Haddad 1,2,3,4,5,6, Patrick W. Gray 8, Tunc Morova 2, Nathan A. Lack 2,9, Raymond J. Andersen 10, Larry Tjoelker 8 and Wilfred A. Jefferies 1,2,3,4,5,6,11,12*  \n1 Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada, 2Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada, 3Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada, 4The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada, 5 Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada, 6 Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada, 7 Biotechnology-Biomedical Science and Technology (BST), University of Applied Sciences, Mannheim, Germany, 8 Pascal Biosciences, Seattle, WA, United States, 9School of Medicine, Ko University, Istanbul, Türkiye,  \n10 Department of Chemistry, University of British Columbia, Vancouver, BC, Canada, 11 Department of Zoology, University of British Columbia, Vancouver, BC, Canada, 12 Department of Urological Science, University of British Columbia, Vancouver, BC, Canada  \nEmerging cancers are sculpted by neo-Darwinian selection for superior growth and survival but minimal immunogenicity; consequently, metastatic cancers often evolve common genetic and epigenetic signatures to elude immune surveillance. Immune subversion by metastatic tumours can be achieved through several mechanisms; one of the most frequently observed involves the loss of expression or mutation of genes composing the MHC-I antigen presentation machinery (APM) that yields tumour","cbCaimZvNlXb3qOi","https://ap.wps.com/l/cbCaimZvNlXb3qOi","pdf",4691394,"English","# Introduction\n# Keywords","[{\"question\":\"What immune-evasion mechanism do metastatic tumors commonly exploit in this study?\",\"answer\":\"Metastatic tumors can evade immune surveillance by losing expression or mutating genes in the MHC-I antigen presentation machinery, reducing CTL recognition.\"},{\"question\":\"Which cannabinoid-related findings were observed in vitro?\",\"answer\":\"Specific cannabinoids, including related compounds such as D9-tetrahydrocannabinol, cannabidiol, and cannabigerol, reversed the metastatic immune-escape phenotype in vitro by inducing MHC-I cell-surface expression, sensitizing tumors to T-cell recognition.\"},{\"question\":\"How were epigenetic effects linked to immune response in the results?\",\"answer\":\"H3K27Ac ChIP-seq analysis showed that cannabigerol and gamma interferon triggered overlapping epigenetic signatures and key pathways in metastatic tumors, including senescence-related pathways and APM genes tied to adaptive immune recognition.\"}]","Specific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours | PDF",1790226469,48]