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It summarizes four original studies and three reviews, highlighting nanoplatform design features such as biocompatible nanoparticles, stimulus-responsive delivery, high loading capacity, and targeting ligands. The issue covers magnetic cobalt ferrite systems for dual-contrast MRI and targeted drug delivery, lipidic nanoparticles for tumor targeting and radiosensitization, and review perspectives on nanoparticle physicochemical tuning, tumor microenvironment modulation, and therapeutic synergy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/special-issue-nanoplatforms-based-cancers-therapy-editorial/385632/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/special-issue-nanoplatforms-based-cancers-therapy-editorial/385632.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main focus of this Special Issue?","Question",{"text":112,"@type":113},"It focuses on innovative nanoplatforms for cancer therapy and imaging, featuring four original articles and three reviews on nanomedicine design and targeting strategies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What key capabilities do nanoplatforms provide in this issue?",{"text":117,"@type":113},"They aim to efficiently target cancer cells, protect and deliver imaging/therapy molecules, enable controlled stimulus-responsive cargo release, and support high loading with anchoring targeting ligands.",{"name":119,"@type":110,"acceptedAnswer":120},"Which themes are emphasized across the reviews?",{"text":121,"@type":113},"The reviews emphasize physicochemical properties and targeting functionalization, strategies to improve tumor penetration under complex micro-environments, and the role of modifying tumor vasculature and the extracellular matrix to enhance nanoparticle accumulation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},385632,1791154699,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":39},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","cancers   \nEditorial  \nSpecial Issue “Nanoplatforms Based Cancers Therapy”Magali Gary-Bobo   \nCitation: Gary-Bobo, M. Special Issue“Nanoplatforms Based Cancers Therapy”. Cancers 2023, 15, 1698 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers15061698  \nReceived: 7 March 2023  \nAccepted: 8 March 2023  \nPublished: 10 March 2023  \nCopyright: © 2023 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nIBMM, University of Montpellier, CNRS, ENSCM, 34093 Montpellier, France; [magali.gary-bobo@umontpellier.fr](magali.gary-bobo@umontpellier.fr)  \nNanomedicine is now considered a hopeful strategy to efficiently target cancer cells and deliver, more specifically, the molecule of interest to the area to image and treat cells. A large variety of biocompatible nanoparticles has been produced in the last few years to carry and protect from biological barriers the molecules designed for imaging or therapy. In addition, a stimuli response system such as laser, temperature, ultrasounds, etc., to deliver the cargo at the site selected, has shown to bring a supplementary dimension for the conception of high-potency controlled nanodevices. Another crucial interest of the nanodevice is the high loading capacity to detect molecules of interest and the ability to be anchored with targeting molecules to efficiently address the nanoplatforms to the tumor area and, more particularly, to cancer cells. This Special Issue, constituted by four original articles and three reviews, focuses on innovative nanoplatforms for the therapy and imaging of cancers.  \nThe first original contribution concerns the elaboration of magnetic cobalt ferrite spinel (MCFS) nanoparticles with unique double-contrast properties enabling effective T1-weighted and T2-weighted magnetic resonance imaging (MRI) [1] . Importantly, these MCFS nanoparticles are efficient for in vivo MRI applications, which are more than most common contrast agents. MCFS nanoparticles were injected in mice and a toxicity study was performed. The structural and functional integrity of kidney, liver, pancreas, and heart were verified, and the safety of these nanoparticles was established. These MCFS nanoparticles can also become a targeted drug delivery system; in addition, they exhibit simultaneous T1-and T2-weighted MRI properties. For this, liposomes encapsulating MCFS nanoparticles and doxorubicin hydrochloride were produced. When encapsulated in PEGylated liposomes loaded with doxorubicin, the efficiency in mice was higher than doxorubicin itself to decrease tumor size. This study demonstrates the potential of the MCFS nanoparticles for a variety of therapeutic and imaging applications.  \nSeveral articles have demonstrated the advantage of liposomes for drugs addressing the area of interest, and in this second article [2], lipidic nanoparticles were loaded with aprodrug (docetaxel) and with gold nanoparticles. The results were very promising as these nanoparticles loaded with docetaxel have a superior targeting of tumor tissues compared to free drug. Importantly, these nanoparticles containing gold nanoparticles exhibited minimal toxicity to normal tissues and an ideal radiosensitization property useful for radiotherapy. Altogether, the data demonstrated synergistic therapeutic effects.  \nIn the same way, the advantages of nanomedicine for cancer targeting were well described in a first review published by Foglizzo and Marchiá [3] who explained why nanoparticles optimize drug delivery to the site of interest by reducing the accumulation in healthy tissues. The use of nanoparticle formulations allows for a selective cancer cells death while avoiding affecting all the cellular network in t","cbCaii6qsbbop11z","https://ap.wps.com/l/cbCaii6qsbbop11z","pdf",184404,"English","# Editorial\n## Nanomedicine and nanoplatform delivery concepts\n## Original article highlights\n## Review articles and tumor microenvironment strategies\n## Clinical and therapeutic implications","[{\"question\":\"What is the main focus of this Special Issue?\",\"answer\":\"It focuses on innovative nanoplatforms for cancer therapy and imaging, featuring four original articles and three reviews on nanomedicine design and targeting strategies.\"},{\"question\":\"What key capabilities do nanoplatforms provide in this issue?\",\"answer\":\"They aim to efficiently target cancer cells, protect and deliver imaging/therapy molecules, enable controlled stimulus-responsive cargo release, and support high loading with anchoring targeting ligands.\"},{\"question\":\"Which themes are emphasized across the reviews?\",\"answer\":\"The reviews emphasize physicochemical properties and targeting functionalization, strategies to improve tumor penetration under complex micro-environments, and the role of modifying tumor vasculature and the extracellular matrix to enhance nanoparticle accumulation.\"}]","Special Issue “Nanoplatforms Based Cancers Therapy” - Editorial | PDF",1790270318]