[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-355678-105":59,"doc-detail-355678-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","spatiotemporal-cancer-control-via-alternating-magnetic-field-activated-nanoantennae-review","Spatiotemporal cancer control via alternating magnetic field-activated nanoantennae - REVIEW","","Magnetic-field-responsive nanoparticles (MFR-NPs) have progressed from magnetic hyperthermia agents into conductive nanomaterials that couple catalytic therapy with electrical current generation under alternating magnetic fields (AMFs). This review covers how tuning composition, size, and morphology improves heating efficiency, energy conversion, and catalytic activity. AMF-driven eddy currents and voltage gradients enable Joule heating and wireless electrochemical stimulation, supporting controlled drug release, enhanced tumor penetration, and redox regulation. Remote electron-transport modulation and magnetically triggered catalytic platforms further promote apoptosis, cuproptosis, and immunogenic cell death, reshaping the tumor microenvironment. Applications in glioblastoma and metastatic cancers suggest synergy with immune checkpoint therapy and potential to overcome barriers such as the blood–brain barrier.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/spatiotemporal-cancer-control-via-alternating-magnetic-field-activated-nanoantennae-review/355678/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/spatiotemporal-cancer-control-via-alternating-magnetic-field-activated-nanoantennae-review/355678.png","ImageObject",300,407,{"name":92,"@type":93},"Aditya","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How do alternating magnetic fields (AMFs) enhance cancer treatment using MFR-NPs beyond heat generation?","Question",{"text":112,"@type":113},"AMFs can induce eddy currents and voltage gradients in conductive nanoparticles, enabling Joule heating and wireless electrochemical stimulation, which supports controlled drug release and redox regulation in tumor cells.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What factors control the heating efficiency of magnetic hyperthermia mediated by MFR-NPs?",{"text":117,"@type":113},"Heating depends on magnetic anisotropy, particle shape and size, nanosystem aggregation, and relaxation/loss mechanisms such as Néel and Brownian relaxation and hysteresis-related losses.",{"name":119,"@type":110,"acceptedAnswer":120},"Which nanoparticle systems are highlighted for remote modulation of electron transport and immune reprogramming?",{"text":121,"@type":113},"The review highlights gold and carbon-based nanoelectrodes with redox-active biomolecules to modulate electron transport, as well as magnetically triggered catalytic platforms that enhance cuproptosis and immunogenic cell death for tumor microenvironment remodeling.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},355678,1790185721,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962085564549,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","NANOMEDICINE  \n2026, VOL. 21, NO. 9, 1319–1347  \n[https://doi.org/10.1080/17435889.2026.2658584](https://doi.org/10.1080/17435889.2026.2658584)  \nREVIEW  \nSpatiotemporal cancer control via alternating magnetic field-activated  \nnanoantennae: coupling heat, electron transport, and immune reprogramming  \nThrinayan Moorthy and Shang-Hsiu Hu  \nDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan (R.O.C.)  \nABSTRACT  \nMagnetic-field-responsive nanoparticles (MFR-NPs) have evolved from traditional magnetic hyperthermia agents into conductive nanomaterials that combine catalytic therapy with electrical current generation under alternating magnetic fields (AMFs) . This review highlights advances in their design, showing how control over composition, size, and morphology improves heating efficiency, energy conversion, and catalytic activity. Beyond magnetic losses, AMFs can induce eddy currents and voltage gradients in conductive nanoparticles, enabling Joule heating and wireless electrochemical stimulation. These effects support controlled drug release, deeper tumor penetration, and regulation of cellular redox processes. Systems such as gold and carbon-based nanoelectrodes with redox-active biomolecules allow remote modulation of electron transport, influencing apoptosis and intracellular signaling. Magnetically triggered catalytic platforms also enhance cuproptosis and immunogenic cell death, promoting the release of DAMPs and TAAs to reshape the tumor microenvironment. Applications in glioblastoma and metastatic cancers show promise, as tailored MFR-NPs can overcome barriers like the blood–brain barrier and work synergistically with immune checkpoint therapies, offering potential for next-generation cancer immunotherapy.  \nARTICLE HISTORY  \nReceived 23 February 2026 Accepted 8 April 2026  \nKEYWORDS  \nAlternating magnetic field; magnetic hyperthermia; electrical current generation; immunotherapy; solid tumor  \n1. Introduction  \nMagnetic fields have evolved over the years into a functional tool for externally stimulating magnetic-field-responsive nanoparticles (MFR-NPs) to deliver controlled and localized magnetic hyperthermia (MHT) for effective cancer therapy. Combining alternating magnetic field (AMFs) and MFR-NPs has begun a trend of transducing electromagnetic energy into thermal energy and facilitating the generation of reactive oxygen species (ROS) within solid tumors, while simultaneously sparing surrounding healthy organs and tissues. MHT mediated by iron-oxide nanoparticles (IONPs) has advanced to early clinical-stage applications, primarily in glioblastoma GBM and prostate cancer, thereby demonstrating the translational potential of MFR-NP-based regimens [1–3] . Moreover, the field has swiftly emerged and evolved beyond conventional MHT and is currently leaning toward multifunctional MFR-NPs that couple diagnostics, pharmacological delivery, and immunomodulatory effects.  \nAt the core of this technology, involving MHT facilitated by MFR-NPs, lie the physics, mechanisms, and interactions between AMF and MFR-NPs. The generation of thermal energy by MFR-NPs depends on various factors, including magnetic anisotropy, shape and size, and nanosystem aggregation, along with Néel and Brownian relaxation, hysteresis loops, and losses, resulting in heat generation at the nanoscale [2,4] . Apart from MHT, exposure to AMF also results in mechanical vibration of nanosystems, leading to lysosomal  \nmembrane disruption and catalyzing ROS generation via Fenton reactions. This, in turn, activates apoptosis/ferroptosiseven without the generation of a substantial amount of heat [5,6] . The sensitivity of these mechanisms can be tuned by varying material composition, surface chemistry, and crystallinity to optimize therapeutic outcomes.  \nOver the years, a wide variety of MFR-NPs have been designed, developed, and scrutinized. One such nanomaterial is superparamagnetic iron-oxide nanop","cbCaidux21hS4CFp","https://ap.wps.com/l/cbCaidux21hS4CFp","pdf",14701222,29,"English","# 1. Introduction\n## Mechanisms and physics of AMF–MFR-NP interactions\n## MFR-NP material platforms and architectures\n# 2. Cancer therapy applications (overview)","[{\"question\":\"How do alternating magnetic fields (AMFs) enhance cancer treatment using MFR-NPs beyond heat generation?\",\"answer\":\"AMFs can induce eddy currents and voltage gradients in conductive nanoparticles, enabling Joule heating and wireless electrochemical stimulation, which supports controlled drug release and redox regulation in tumor cells.\"},{\"question\":\"What factors control the heating efficiency of magnetic hyperthermia mediated by MFR-NPs?\",\"answer\":\"Heating depends on magnetic anisotropy, particle shape and size, nanosystem aggregation, and relaxation/loss mechanisms such as Néel and Brownian relaxation and hysteresis-related losses.\"},{\"question\":\"Which nanoparticle systems are highlighted for remote modulation of electron transport and immune reprogramming?\",\"answer\":\"The review highlights gold and carbon-based nanoelectrodes with redox-active biomolecules to modulate electron transport, as well as magnetically triggered catalytic platforms that enhance cuproptosis and immunogenic cell death for tumor microenvironment remodeling.\"}]","Spatiotemporal cancer control via alternating magnetic field-activated nanoantennae - REVIEW | PDF",1790120473,73]