[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-362785-105":59,"doc-detail-362785-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","spatial-tumor-evolution-panorama-of-ovarian-cancer-article-highlights","Spatial tumor evolution panorama of ovarian cancer - Article highlights","","Ovarian cancer is an aggressive disease marked by intraperitoneal dissemination and a distinctive tumor microenvironment. By integrating spatial transcriptomics with whole-genome and RNA sequencing, plus single-cell data, the study defines site-specific tumor-host colocalization and a Darwinian evolutionary path shaped by hypoxia and immune pressure. A tripartite ensemble involving SPP1+ macrophages and MMP11+ myCAFs drives metastasis, while SPP1-CD44 inhibition reduces metastatic spread and SPP1+ macrophages predict therapeutic responses in clinical settings.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/spatial-tumor-evolution-panorama-of-ovarian-cancer-article-highlights/362785/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/spatial-tumor-evolution-panorama-of-ovarian-cancer-article-highlights/362785.png","ImageObject",300,407,{"name":92,"@type":93},"Angel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What drives tumor evolution and metastasis in this study?","Question",{"text":113,"@type":114},"STARLETS framework reveals Darwinian evolution where hypoxia and immune pressures select clones that ultimately metastasize.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which cell ensemble is identified as promoting metastasis?",{"text":118,"@type":114},"A tripartite ensemble composed of SPP1+ macrophages, MMP11+ myCAFs, and epithelial cells is detected in ascites and metastases.",{"name":120,"@type":111,"acceptedAnswer":121},"How could therapy be guided based on these findings?",{"text":122,"@type":114},"SPP1-CD44 inhibition reduces metastasis, and SPP1+ macrophages are reported to predict therapy response in clinical trials including oncolytic virus and PARP inhibitor treatments.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},362785,1790293331,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},687207412472,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Article  \nSpatial tumor evolution panorama of ovarian cancer  \nAuthors  \nChenzhao Feng (冯晨钊), Yunyi Yang (杨允宜), Guanchu Li (李冠初), ..., Fuxia Li (李福霞), Gang Chen(陈刚), Chaoyang Sun (孙朝阳)  \nCorrespondence  \n[peng_wang@fudan.edu.cn](peng_wang@fudan.edu.cn) (P.W.),  \n[dingma424@yahoo.com](dingma424@yahoo.com) (D.M.),  \n[lifuxia36@qq.com](lifuxia36@qq.com) (F.L.),  \n[gumpc@126.com](gumpc@126.com) (G.C.),  \n[suncydoctor@gmail.com](suncydoctor@gmail.com) (C.S.)  \nIn brief  \nFeng et al. reveal how ovarian cancer cells evolve under immune and hypoxic pressures by STARLETS. By integrating spatial transcriptomics and single-cell and genomic analyses, they identify cell ensembles that drive metastasis and predict therapy response, providing insights into tumor-host dynamics and potential therapeutic strategies.  \n• STARLETS traces Darwinian evolution driving metastasis under hypoxia and immunity  \n• A tripartite ensemble formed by SPP1+ macrophages, MMP11+ myCAFs, and epithelium  \n• Targeting SPP1-CD44 reduces metastasis and SPP1+ macrophages predict therapy response  \nFeng et al., 2026, Cell Reports Medicine 7, 102666  \nMarch 17, 2026 © 2026 The Authors. Published by Elsevier Inc.  \n[https://doi.org/10.1016/j.xcrm.2026.102666](https://doi.org/10.1016/j.xcrm.2026.102666)  \nll  \nll  \nOPEN ACCESS  \nArticle  \nSpatial tumor evolution panorama of ovarian cancer  \nChenzhao Feng (冯晨钊),1,2,3,13 Yunyi Yang (杨允宜),1,2,13 Guanchu Li (李冠初),1,2,13 Zixuan Fang (方紫璇),1,2,13 Bin Yang (杨斌),1,2 Fang Zhao (赵方),4 Xingyu Chen (陈星宇),4 Shuyi Liu (刘书艺),1,2 Di Wu (吴迪),1,2 Xingyuan Hu (胡杏媛),1,2 Jingjing Yin (尹静静),1,2 Siyang Zhang (张思扬),5 Junpeng Fan (樊俊鹏),1,2 Wenju Peng (彭文举),1,2 Zhe Hu (胡哲),1,2 Zimeng Wu (兀紫梦),1,2 Yu Fu (付裕),1,2 Funian Lu (陆富年),1,2 Tianyu Qin (秦天宇),1,2 Beibei Wang (王蓓蓓),1,2  \nGordon B. Mills,6 Xin Zhou (周欣),5 Jing Li (李晶),7 Tao Zhu (朱滔),8 Peng Fei (费鹏),4 Peng Wang (王鹏),9,10,11,* Ding Ma (马丁),1,2,* Fuxia Li (李福霞),3,12,* Gang Chen (陈刚),1,2,* and Chaoyang Sun (孙朝阳)1,2,14,*  \n1Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China  \n2Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China  \n3NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital of Shihezi University), Shihezi, Xinjiang 832003, China  \n4School of Optical and Electronic Information-Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China  \n5Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, China  \n6Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA  \n7Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, 33 Yingfeng Road, Guangzhou, Guangdong 510000, China  \n8Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China  \n9Department of Hepatic Oncology, Zhongshan Hospital, Fudan University, Shanghai 200000, China  \n10Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200000, China  \n11Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200000, China  \n12Department of Obstetrics and Gynecology, First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang 832003, China  \n13These authors contributed equally  \n14Lead contact  \n*Correspondence: [peng_wang@fudan.edu.cn](peng_wang@fudan.edu.cn) (P.W.), [dingma424@yahoo.com](dingma424@yahoo.com) (D. M.), [lifuxia36@qq.com](lifuxia36@qq.com) (F. L.), [gumpc@126.com](gumpc@126.com) (G.C.), [suncydoctor@gmail.com](suncydoctor@gmail.com) (C.S.)  \n[https://doi.org/10.1016/j.xcrm.2026.","cbCaiqdp0My2hwxP","https://ap.wps.com/l/cbCaiqdp0My2hwxP","pdf",20840591,36,"English","# Summary\n# Introduction","[{\"question\":\"What drives tumor evolution and metastasis in this study?\",\"answer\":\"STARLETS framework reveals Darwinian evolution where hypoxia and immune pressures select clones that ultimately metastasize.\"},{\"question\":\"Which cell ensemble is identified as promoting metastasis?\",\"answer\":\"A tripartite ensemble composed of SPP1+ macrophages, MMP11+ myCAFs, and epithelial cells is detected in ascites and metastases.\"},{\"question\":\"How could therapy be guided based on these findings?\",\"answer\":\"SPP1-CD44 inhibition reduces metastasis, and SPP1+ macrophages are reported to predict therapy response in clinical trials including oncolytic virus and PARP inhibitor treatments.\"}]","Spatial tumor evolution panorama of ovarian cancer - Article highlights | PDF",1790149090,91]