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Findings show dose to inferior pharyngeal constrictor, cricopharyngeus, and glottic larynx predicts dysphagia for semisolids and liquids, while esophageal inlet predicts only liquid outcomes. Conclusion: sparing SRSs during radiotherapy improves swallowing 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was the study objective regarding swallowing-related structures (SRSs)?","Question",{"text":63,"@type":64},"The study aimed to identify SRSs that predict post-radiotherapy dysphagia in oropharyngeal carcinoma patients.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were swallowing outcomes assessed in the study?",{"text":68,"@type":64},"Swallowing was evaluated using flexible endoscopic evaluation of swallowing (FEES) with dysphagia grading.",{"name":70,"@type":61,"acceptedAnswer":71},"Which SRS radiation doses significantly predicted dysphagia after radiotherapy?",{"text":72,"@type":64},"Radiation doses to the inferior pharyngeal constrictor, cricopharyngeus, and glottic larynx significantly predicted dysphagia for both semisolids and liquid diets.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},336350,1790457021,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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Structures Reduces PostRadiotherapy Dysphagia in Oropharyngeal Cancer  \nChanin Wasuthalainun1, Phawin Keskool1*, Janjira Petsuksiri2, Sunun Ongard1, Paiboon Sureepong1  \nAbstract  \nObjective: To identify swallowing-related structures (SRSs) predicting post-radiotherapy dysphagia in oropharyngeal carcinoma patients. Material and methods: Between September 2020 and October 2022, oropharyngeal cancer patients who had completed radiotherapy at least one year before without recurrence or residuals were selected. They underwent flexible endoscopic evaluation of swallowing (FEES) assessments and dysphagia grading. The mean radiation doses delivered to their SRSs were recalculated. The correlation between radiation doses to each SRS and FEES scores was analysed. Results: Twenty-nine participants, aged 51–73 years, were enrolled. Six patients had received twodimensional radiotherapy, eight had undergone three-dimensional conformal radiotherapy, and fifteen had received intensity-modulated radiation therapy. Radiation doses to the inferior pharyngeal constrictor, cricopharyngeus and glottic larynx significantly predicted dysphagia for both semisolids (p = 0.023, 0.030 and 0.001) and liquid diets (p = 0.021, 0.013 and 0.002). The esophageal inlet significantly predicted swallowing outcomes for only the liquid diet (p = 0.007). Conclusions: This study supports that SRS-sparing during radiotherapy for oropharyngeal cancers improves swallowing outcomes.  \nKeywords: Dysphagia-Oropharyngeal cancer-Radiation doses-Radiation therapy-Swallowing-related structures  \nAsian Pac J Cancer Prev, 25 (4), 1451-1456  \nIntroduction  \nRadiotherapy plays a crucial role in the treatment of cancer, particularly oropharyngeal cancer. Therapeutic radiation therapy utilises higher energy X-rays than diagnostic radiology. While high doses of radiation can eliminate cancer cells, they can also harm adjacent normal cells [1]. The acute effects of radiation therapy typically persist for approximately 8 to 12 weeks after treatment cessation. Additionally, there are long-term effects, such as soft tissue fibrosis and xerostomia. Tissue fibrosis affects the mobility of the tongue and pharyngeal muscles and the elevation of the larynx and hyoid [2] . Dysphagia, a significant complication of head and neck radiation therapy, becomes particularly pronounced when the radiation area encompasses a large portion of the neck. Consequently, dysphagia can profoundly impact patients’quality of life [3] .  \nAdvancementsin computer technology have facilitated the transition from basic 2-dimensional radiotherapy (2DRT) to a more sophisticated approach known as 3-dimensional conformal radiotherapy (3DCRT) . 3DCRT has been developed to limit the radiation  \ndose to the planning target volume while minimising radiation spillage beyond the target area [4] . Intensitymodulated radiotherapy (IMRT) is a novel radiation treatment approach employing computer-controlled linear accelerators to deliver precise radiation doses to malignant tumours or specific areas within a tumour [5-7] . IMRT allows for the concentration of higher radiation doses on the intended target while minimising radiation exposure to surrounding normal structures.  \nThe structures involved in swallowing (swallowingrelated structures or SRSs) comprise the superior, middle and inferior posterior constrictor muscles; cricopharyngeus muscle; esophageal inlet; base of the tongue; supraglottis; and glottic larynx. These structures may be impacted during radiotherapy for oropharyngeal cancers. Therefore, an advanced radiation technique that reduces the radiation dose to the SRSs could help mitigate swallowing problems [1, 8, 9] .  \nFlexible endoscopic evaluation of swallowing (FEES) is a standardized, precise and highly safe objective procedure for assessing swallowing parameters [10-12] . We hypothesized that different","cbCaisxEAPs5vbUS","https://ap.wps.com/l/cbCaisxEAPs5vbUS","pdf",620844,"English","# Abstract\n# Introduction\n# Materials and Methods","[{\"question\":\"What was the study objective regarding swallowing-related structures (SRSs)?\",\"answer\":\"The study aimed to identify SRSs that predict post-radiotherapy dysphagia in oropharyngeal carcinoma patients.\"},{\"question\":\"How were swallowing outcomes assessed in the study?\",\"answer\":\"Swallowing was evaluated using flexible endoscopic evaluation of swallowing (FEES) with dysphagia grading.\"},{\"question\":\"Which SRS radiation doses significantly predicted dysphagia after radiotherapy?\",\"answer\":\"Radiation doses to the inferior pharyngeal constrictor, cricopharyngeus, and glottic larynx significantly predicted dysphagia for both semisolids and liquid diets.\"}]","Sparing Swallowing-Related Structures Reduces Post-Radiotherapy Dysphagia in Oropharyngeal Cancer | PDF",1790014665,15]