[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-366425-105":59,"doc-detail-366425-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","sox9-an-important-factor-in-regulating-breast-cancer-review","SOX9: an important factor in regulating breast cancer - Review","","The SRY-Box Transcription Factor 9 (SOX9) is presented as a key transcription factor regulating progenitor cell growth, differentiation, and stemness. Evidence indicates SOX9 protein influences tumor initiation, proliferation, migration, and chemotherapy resistance, driving onset and progression. Although SOX9 overexpression is commonly observed in breast cancer, its detailed molecular mechanism remains unclear. This review consolidates SOX9 structure, functions, and recent advances, arguing that SOX9 targeting may enhance breast cancer treatment outcomes and support clinical decision-making.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sox9-an-important-factor-in-regulating-breast-cancer-review/366425/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sox9-an-important-factor-in-regulating-breast-cancer-review/366425.png","ImageObject",300,407,{"name":92,"@type":93},"Mabel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does SOX9 play in progenitor cells and breast cancer?","Question",{"text":112,"@type":113},"SOX9 controls growth, differentiation, and stemness of progenitor cells. In breast cancer, it is implicated in tumor initiation, progression, and chemotherapy resistance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is SOX9 considered important for tumor progression?",{"text":117,"@type":113},"SOX9 is reported to participate directly in tumor initiation, proliferation, migration, and chemotherapy resistance, which are central steps in cancer development.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the review suggest using SOX9 for breast cancer treatment?",{"text":121,"@type":113},"The review proposes that targeting SOX9 could improve therapeutic effects in breast cancer, while also providing a reference for clinical work.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},366425,1791009061,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},7971474920318,"https://ap-avatar.wpscdn.com/avatar/74000ee537e6b0ca360?x-image-process=image/resize,m_fixed,w_180,h_180&k=1788430171632181674","Wang et al. European Journal  \nEuropean Journal of Medical Research (2025) 30:759  \n[https://doi.org/10.1186/s40001-025-02730-0](https://doi.org/10.1186/s40001-025-02730-0 of Medical Research)[ of Medical Research](https://doi.org/10.1186/s40001-025-02730-0 of Medical Research)  \n REVIEW Open Access  \nSOX9: an important factor in regulating breast cancer  \nYaru Wang1, Juhang Chu1, Luyao Huang1 and Mingping Qian1*  \nAbstract  \nThe SRY-Box Transcription Factor 9 (SOX9) is a crucial transcription factor that controls the growth, differentia  \ntion, and stemness of progenitor cells. According to research, SOX9 protein controls the initiation and progression of tumors by directly participating in tumor initiation, proliferation, migration, and chemotherapy resistance. Although SOX9 overexpression is frequently found in breast cancer, the precise molecular mechanism is yet unknown. This article reviews the structure, function, and new developments of SOX9 in the pathogenesis and treatment of breast cancer, and proposes that targeting SOX9 may improve the therapeutic effect of breast cancer and provide a reference for clinical work.  \nKeywords Breast cancer, SOX9, Occurrence, Development, Treatment  \nIntroduction  \nBreast cancer (BC), as one of the malignant tumors that endanger women’s health in the world, has surpassed lung cancer in its incidence and ranked first in the global incidence of malignant tumors in 2020, and the mortality is increasing year by year. There are a variety of classification methods for BC, and at present, the following molecular typing is mostly used: according to estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67, etc., can be divided into: ① luminal type A: ER/PR-positive, and PR expression is high (≥20%), HER2-negative, Ki-67 expression is low (\u003C14%); ② luminal type B: including HER2-negative (ER-positive, HER2-negative, and at least one of the following: Ki-67 high expression (≥ 14%), PR-negative or low expression (\u003C 20%)), HER2-positive (ER-positive, HER2 overexpression, Ki-67 in any state, PR in any state); ③ HER2 overexpression type: HER2 overexpression or proliferation, ER and PR-negative;  \n*Correspondence: Mingping Qian [qian_mp1@126.com](qian_mp1@126.com)  \n1 Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China  \n④ basal-like type: triple-negative, ER, PR, HER2 are all negative.  \nThe main methods of BC treatment include surgery, radiotherapy, chemotherapy, endocrine therapy, targeted therapy, immunotherapy, and traditional Chinese medicine treatment [1]. Although great progress has been made in the early detection and treatment of BC in recent years, problems such as drug resistance and metastasis also greatly affect the quality of life of BC patients.  \nIn the early 1990s of the twentieth century, a transcription factor with a unique DNA-binding domain was discovered, and because the gene encoding this transcription factor is located on the Y-chromosome, it is called a sex-determining region of Y-chromosome (SRY). Based on their sequence and function, 20 SOX genes containing HMG domains were identified in the mouse and human genomes. Eight subgroups of the genes—SOX A through H—each with 1–3 members—make up the genes. The E subgroup includes SOX9, SOX8, and SOX10 as members. Three helixes make up the SRY-associated HMG domain in SOX9 (Fig. 1) [2]. This gene produces a protein that recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins.  \nThe protein encoded by the SOX9 gene performs a crucial part in the differentiation of chondrocytes and the  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original aut","cbCainwjqdapft10","https://ap.wps.com/l/cbCainwjqdapft10","pdf",2231996,"English","# Abstract\n# Keywords\n# Introduction\n## Breast cancer overview and molecular subtypes\n## Treatment approaches and challenges\n## SOX9 background: genes and protein domain\n## SOX9 functions in development and cancer","[{\"question\":\"What role does SOX9 play in progenitor cells and breast cancer?\",\"answer\":\"SOX9 controls growth, differentiation, and stemness of progenitor cells. In breast cancer, it is implicated in tumor initiation, progression, and chemotherapy resistance.\"},{\"question\":\"Why is SOX9 considered important for tumor progression?\",\"answer\":\"SOX9 is reported to participate directly in tumor initiation, proliferation, migration, and chemotherapy resistance, which are central steps in cancer development.\"},{\"question\":\"How does the review suggest using SOX9 for breast cancer treatment?\",\"answer\":\"The review proposes that targeting SOX9 could improve therapeutic effects in breast cancer, while also providing a reference for clinical work.\"}]","SOX9: an important factor in regulating breast cancer - Review | PDF",1790165483,23]