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Terminal exhaustion phenotypes of effector T-cells and the accumulation of myeloid-derived suppressor cells (MDSC) are well characterized in established SCC, but the specific precancerous lesions that carry a bona fide high risk for malignant transformation remain unclear, including how epithelial dysplasia reshapes immune regulation toward irreversibility.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sox2-induced-il1-mediated-immune-suppression-drives-epithelial-dysplasia-malignant-transformation/331649/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sox2-induced-il1-mediated-immune-suppression-drives-epithelial-dysplasia-malignant-transformation/331649.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What precursor lesions can precede squamous cell carcinomas (SCC)?","Question",{"text":112,"@type":113},"SCC are often preceded by potentially malignant precursor lesions, most of which remain benign.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What immune features are known in established SCC?",{"text":117,"@type":113},"Terminal exhaustion phenotypes of effector T-cells and the accumulation of myeloid-derived suppressor cells (MDSC) have been thoroughly characterized in established SCC.",{"name":119,"@type":110,"acceptedAnswer":120},"What remains unclear about precancerous epithelial dysplasia?",{"text":121,"@type":113},"It is unclear which precancerous lesions have a bona fide high risk for malignant transformation and how precancerous epithelial dysplasia drives the immune system toward a no-return state.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331649,1790172506,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","bioRxiv preprint doi: [https://doi.org/10.1101/2024.12.06.626475](https://doi.org/10.1101/2024.12.06.626475); this version posted December 10, 2024. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made  \navailable under aCC-BY-ND 4.0 International license.  \n1 Title: SOX2-induced IL1α-mediated immune suppression drives epithelial dysplasia malignant  \n2 transformation  \n3  \n4 Authors: Hülya F. Taner2 , Wang Gong3 , Zackary R. Fitzsimonds3 , Zaiye Li3 , Yuesong Wu4 ,  \n5 Yumin He3 , Kohei Okuyama3 , Wanqing Cheng5 , Jung Kuczura6 , Sashider Rajesh7 , Andriana  \n6 Manousidaki4 , Shuo Feng8 , Miki Lee8 , Felipe Nör9 , Emily Lanzel 10 , Shadmehr Demehri 11 , Peter  \n7 J. Polverini9 , Jacques E. Nör2 , 12 , 13 , Thomas D. Wang8 , Jianwen Que14 , Haitao Wen 15 , Yuying  \n8 Xie4,16 , James J. Moon6 , 17 , Yu Leo Lei1 ,2,3 ,5,18*  \n9  \n10 Affiliations:  \n11 1 Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center,  \n12 Houston, TX 77030 , USA.  \n13 2Oral Health Sciences DDS/PhD Program, University of Michigan School of Dentistry, Ann  \n14 Arbor, MI 48105 , USA.  \n15 3 Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX  \n16 77054 , USA.  \n17 4 Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824,  \n18 USA  \nbioRxiv preprint doi: [https://doi.org/10.1101/2024.12.06.626475](https://doi.org/10.1101/2024.12.06.626475); this version posted December 10, 2024. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made  \navailable under aCC-BY-ND 4.0 International license.  \n19 5Graduate School of Biomedical Sciences, the University of Texas M. D. Anderson Cancer  \n20 Center and UTHealth Houston, Houston, TX 77030, USA.  \n21 6 Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA.  \n22 7 Department of Chemistry, University of Michigan, Ann Arbor, MI 48105, USA.  \n23 8 Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105,  \n24 USA  \n25 9 Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann  \n26 Arbor, MI 48105 , USA.  \n27 10Department of Oral Pathology, Radiology, and Medicine, University of Iowa College of  \n28 Dentistry, Iowa City, IA 52242 , USA.  \n29 11Department of Dermatology , Massachusetts General Hospital, Boston, MA 02114 , USA.  \n30 12Department of Otolaryngology – Head and Neck Surgery, University of Michigan Medical  \n31 School, Ann Arbor, MI 48105 , USA.  \n32 13Department of Cariology, Restorative Science and Endodontics, University of Michigan School  \n33 of Dentistry, Ann Arbor, MI 48105 , USA.  \n34 14Department of Medicine, Columbia University Herbert Irving Comprehensive Cancer Center,  \n35 New York, NY 10032, USA.  \nbioRxiv preprint doi: [https://doi.org/10.1101/2024.12.06.626475](https://doi.org/10.1101/2024.12.06.626475); this version posted December 10, 2024. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made  \navailable under aCC-BY-ND 4.0 International license.  \n36 15Department of Microbial Infection and Immunity, Ohio State University College of Medicine,  \n37 Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.  \n38 16 Department of Computational Mathematics Science and Engineering, Michigan State  \n39 University, East Lansing, MI 48864, USA.  \n40 17Department of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann  \n41 Arbor, MI 48105 , USA.  \n42 18Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer  \n43 Center, Houston, TX 77054 , USA.  ","cbCaivaBGy2IW37M","https://ap.wps.com/l/cbCaivaBGy2IW37M","pdf",4139774,71,"English","# Abstract\n## Background and clinical problem\n## Immune mechanisms in SCC\n## Open question about dysplasia and transformation","[{\"question\":\"What precursor lesions can precede squamous cell carcinomas (SCC)?\",\"answer\":\"SCC are often preceded by potentially malignant precursor lesions, most of which remain benign.\"},{\"question\":\"What immune features are known in established SCC?\",\"answer\":\"Terminal exhaustion phenotypes of effector T-cells and the accumulation of myeloid-derived suppressor cells (MDSC) have been thoroughly characterized in established SCC.\"},{\"question\":\"What remains unclear about precancerous epithelial dysplasia?\",\"answer\":\"It is unclear which precancerous lesions have a bona fide high risk for malignant transformation and how precancerous epithelial dysplasia drives the immune system toward a no-return state.\"}]","SOX2-induced IL1α-mediated immune suppression drives epithelial dysplasia malignant transformation | PDF",1789994449,179]