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This systematic review examined breast cancer patients across 21 Latin American countries, identifying studies with clinical data to build a combined clinical-genetic evidence base. Mutation frequencies across subtypes were compared using statistical and meta-analytic methods, with functional enrichment revealing overexpressed biological processes and canonical pathways. Key findings included 342 mutations, prominently TP53 and PIK3CA (notably H1047R), supporting insights into tumor biology, potential therapies, and the value of tailored treatment strategies and targeted combinations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/somatic-mutations-in-latin-american-breast-cancer-patients-a-systematic-review-and-meta-analysis/326894/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/somatic-mutations-in-latin-american-breast-cancer-patients-a-systematic-review-and-meta-analysis/326894.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why does the review focus on Latin American breast cancer patients?","Question",{"text":112,"@type":113},"Latin American women are underrepresented in clinical trials and often have limited access to somatic analysis in their countries.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the evidence gathered in the systematic review?",{"text":117,"@type":113},"The review synthesized studies from 21 Latin American countries using multiple databases, then selected 10 studies with clinical data suitable for building a clinical-genetic database.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main mutation findings?",{"text":121,"@type":113},"Across six Latin American countries, 342 mutations were identified, with TP53 and PIK3CA most studied; the most common PIK3CA mutation was H1047R.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},326894,1790922094,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","diagnostics  \nSystematic Review  \nSomatic Mutations in Latin American Breast Cancer Patients: A Systematic Review and Meta-Analysis  \nGabriela A. Martínez-Nava 1,†, Laura Keren Urbina-Jara 2,†, Saúl Lira-Albarrán 3, Henry L. Gómez 4,  \nErika Ruiz-García 5, María Tereza Nieto-Coronel 6, Rocio Ortiz-Lopez 2,7, Kenia Nadiezhda Martínez Villalba 8, Mariana Muñoz-Sánchez 9, Dione Aguilar 10, Liliana Gómez-Flores-Ramos 11, Sara Aileen Cabrera-Nieto 9, Alejandro Mohar 8 and Marlid Cruz-Ramos 12, *  \nCitation: Martínez-Nava, G.A.;  \nUrbina-Jara, L.K.; Lira-Albarrán, S.; Gómez, H.L.; Ruiz-García, E.;  \nNieto-Coronel, M.T.; Ortiz-Lopez, R.; Martínez Villalba, K.N.;  \nMuñoz-Sánchez, M.; Aguilar, D.; et al. Somatic Mutations in Latin American Breast Cancer Patients: A Systematic Review and Meta-Analysis. Diagnostics 2024, 14, 287. [https://](https://)[ ](https://)[doi.org/10.3390/diagnostics14030287](doi.org/10.3390/diagnostics14030287)  \nAcademic Editor: Dario Marchetti  \nReceived: 30 November 2023  \nRevised: 16 January 2024  \nAccepted: 18 January 2024  \nPublished: 29 January 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Laboratorio de Gerociencias, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Calz. México-Xochimilco 289, Tlalpan, Mexico City 14389, Mexico; [ameria.justice@gmail.com](ameria.justice@gmail.com)  \n2 Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64710, Mexico; [lauraqcb@gmail.com](lauraqcb@gmail.com) (L.K.U.-J.); [rortizl@tec.mx](rortizl@tec.mx) (R.O.-L.)  \n3 Departamento de Gestión Académica e Investigación, Hospital Escuela, Tegucigalpa 11101, Honduras; [saul.lira@hospitalescuela.edu.hn](saul.lira@hospitalescuela.edu.hn)  \n4 Departmento de Medicina Oncológica, Instituto Nacional de Enfermedades Neoplásicas, Av. Angamos Este 2520, Lima 15023, Peru; [hgomez@inen.sld.pe](hgomez@inen.sld.pe)  \n5 Laboratorio de Medicina Traslacional, Instituto Nacional de Cancerologia, Mexico City 14080, Mexico; [betzabe100@yahoo.com.mx](betzabe100@yahoo.com.mx)  \n6 Departamento de Medicina Oncológica, Centro Oncopalia, Universidad Mayor de San Andrés, La Paz P.O. Box 8635, Bolivia; [maytemtnc2@gmail.com](maytemtnc2@gmail.com)  \n7 Tecnologico de Monterrey, Institute for Obesity Research, Monterrey 64849, Mexico  \n8 Unidad de Epidemiología e Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, UNAM-Instituto Nacional de Cancerología, Mexico City 14080, Mexico;  \n[kenia28nadiezhda@gmail.com](kenia28nadiezhda@gmail.com) (K.N.M.V.); [mohar@iibiomedicas.unam.mx](mohar@iibiomedicas.unam.mx) (A.M.)  \n9 Facultad de Ciencias de la Salud, Universidad Anáhuac México, Mexico City 52786, Mexico; [mariana.munozsa@anahuac.mx](mariana.munozsa@anahuac.mx) (M.M.-S.); [sara.cabrera32@anahuac.mx](sara.cabrera32@anahuac.mx) (S.A.C.-N.)  \n10 Tecnologico de Monterrey, Centro de Cáncer de Mama, Hospital Zambrano Hellion, San Pedro Garza García 66278, Mexico; [oncogenetica.monterrey@gmail.com](oncogenetica.monterrey@gmail.com)  \n[11](11 CONAHCYT/Center for Population Health Research)[ CONAHCYT/Center for Population Health Research](11 CONAHCYT/Center for Population Health Research), [National Institute of Public Health](National Institute of Public Health), Universidad No. 655, Cuernavaca 62100, Mexico; [liliana.gomez@insp.mx](liliana.gomez@insp.mx)  \n12 Programa Joven y Fuerte/CONAHCYT, Instituto Nacional de Cancerología, Av. San Fernando 22, Belisario Domínguez Sección 16, Tlalpan, Mexico City 14080, Mexico  \n* [Correspondence: marlid.cruz@gmail.com](Correspondence: marlid.cruz@gmail.com)  \n† Authors: Gabriela A. Martínez-Nava and Laura Keren Urbina-Jara should be consider","cbCaile6IxJavw00","https://ap.wps.com/l/cbCaile6IxJavw00","pdf",1798488,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion","[{\"question\":\"Why does the review focus on Latin American breast cancer patients?\",\"answer\":\"Latin American women are underrepresented in clinical trials and often have limited access to somatic analysis in their countries.\"},{\"question\":\"How was the evidence gathered in the systematic review?\",\"answer\":\"The review synthesized studies from 21 Latin American countries using multiple databases, then selected 10 studies with clinical data suitable for building a clinical-genetic database.\"},{\"question\":\"What were the main mutation findings?\",\"answer\":\"Across six Latin American countries, 342 mutations were identified, with TP53 and PIK3CA most studied; the most common PIK3CA mutation was H1047R.\"}]","Somatic Mutations in Latin American Breast Cancer Patients - A Systematic Review and Meta-Analysis | PDF",1789975678,48]