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Head and neck involvement is exceptionally uncommon. This case report describes a solitary mandibular recurrence in a 56-year-old woman with stage II clear cell uterine carcinoma, initially treated by surgery followed by paclitaxel and carboplatin. After pembrolizumab plus lenvatinib, the mandibular tumor became undetectable and the response has been maintained.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/solitary-mandibular-recurrence-of-uterine-endometrial-carcinoma-successfully-treated-with-chemotherapy-alone-a-case-report/453832/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/solitary-mandibular-recurrence-of-uterine-endometrial-carcinoma-successfully-treated-with-chemotherapy-alone-a-case-report/453832.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is mandibular recurrence in endometrial carcinoma notable?","Question",{"text":112,"@type":113},"Recurrence of endometrial carcinoma typically occurs in the pelvic region, while distant metastases more often involve the lungs and lymph nodes. Head and neck recurrences are exceedingly rare, making mandibular involvement unusual.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What symptoms led to discovery of the mandibular lesion?",{"text":117,"@type":113},"About two months after completing chemotherapy, the patient developed progressive trismus and left mandibular pain, initially evaluated as a temporomandibular joint disorder. Imaging later revealed a mass in the left mandible.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment was used for the solitary mandibular recurrence and what was the outcome?",{"text":121,"@type":113},"The patient received pembrolizumab and lenvatinib therapy. After treatment, the mandibular tumor was no longer detectable, and the response has been maintained.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},453832,1790784663,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52,"preview_page_count":4},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","Gynecologic Oncology Reports 63 (2026) 102013  \nContents lists available at ScienceDirect  \nGynecologic Oncology Reports  \njournal [homepage:](homepage: www.elsevier.com/locate/gynor)[ www.elsevier.com/locate/gynor](homepage: www.elsevier.com/locate/gynor)  \n| Case report\u003Cbr>Solitary mandibular recurrence of uterine endometrial carcinoma successfully treated with chemotherapy alone: A case report\u003Cbr>*\u003Cbr>Takato Ishida , Shoji Maenohara , Hiroshi Yagi , Hideaki Yahata , Kiyoko Kato\u003Cbr>Department of Obstetrics and Gynecology, Kyushu University Hospital, Japan |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords:\u003Cbr>Endometrial carcinoma Chemotherapy Mandibular recurrence Pembrolizumab |  | Background: Recurrence of endometrial carcinoma typically occurs in the pelvic region, with the lungs and lymph nodes being common sites for distant metastasis. However, recurrence involving the head and neck region is exceedingly rare.\u003Cbr>Case presentation: We report a case of solitary mandibular recurrence of endometrial carcinoma successfully treated with lenvatinib and pembrolizumab. A 56-year-old woman was diagnosed with stage II clear cell carcinoma of the uterus. She underwent total abdominal hysterectomy, bilateral adnexectomy, partial omentectomy, appendectomy, pelvic and para-aortic lymphadenectomy. Postoperative adjuvant chemotherapy with six cycles of paclitaxel and carboplatin was administered, followed by observation. Two months after the completing of treatment, the patient developed trismus and pain in the left mandible. Imaging studies revealed a 4 cm massin the left mandible. Needle biopsy confirmed a solitary recurrence of endometrial carcinoma. After the administration of pembrolizumab and lenvatinib therapy, the tumor was no longer detectable, which has been maintained.\u003Cbr>Conclusion: Mandibular metastasis from endometrial carcinoma is extremely rare and may mimic primary jaw tumors. Treatment options include surgical resection, radiotherapy, and systemic therapy. A comprehensive evaluation of the primary tumor status, presence of other metastases, and the patient’s functional condition is essential for determining the optimal therapeutic strategy. |\n\n1. Introduction  \nAccording to the latest reports on endometrial carcinoma in Japan, the 5-year survival rate is 94.1 % for stage I and 88.8 % for stage II, indicating good outcomes and a relatively low risk of recurrence (Kajiyama et al., 2025). It has been reported that half of the recurrence sites for endometrial carcinoma are confined to the pelvic region, while distant metastases are often found in the lungs and lymph nodes (Aalders et al., 1984). Recurrences with metastasis to the head and neck are rare, but have been described in sporadic case reports.  \nHerein, we report a rare case of stage II endometrial clear cell carcinoma that developed a solitary recurrence in the mandibular bone. The patient was treated with lenvatinib and pembrolizumab (LP) therapy and had a favorable clinical course.  \n2. Case presentation  \nA 56-year-old nulligravida woman presented with abnormal uterine  \nbleeding and was referred to our department for further evaluation following a cervical cytology result of atypical glandular cells and a cervical biopsy raising the suspicion of adenocarcinoma. Endometrial biopsy performed at our institution confirmed clear cell carcinoma. Pelvic contrast-enhanced MRI suggested invasion of more than half of the myometrium, and the lesion was localized to the uterus. Contrastenhanced CT scan of the neck, chest, and pelvis showed no distant metastasis or lymphadenopathy. The patient was diagnosed with endometrial carcinoma, and had a total abdominal hysterectomy, bilateral adnexectomy, partial omentectomy, appendectomy, pelvic lymphadenectomy, and para-aortic lymphadenectomy.  \nIn the postoperative pathology, clear cell carcinoma was identified, with myometrial invasion of 8/18 mm, positivity for stromal invasion in the cerv","cbCaipaLzbF5rCcl","https://ap.wps.com/l/cbCaipaLzbF5rCcl","pdf",4982893,"English","# Case report\n## Background\n## Case presentation\n## Conclusion\n# Introduction\n# Case presentation","[{\"question\":\"Why is mandibular recurrence in endometrial carcinoma notable?\",\"answer\":\"Recurrence of endometrial carcinoma typically occurs in the pelvic region, while distant metastases more often involve the lungs and lymph nodes. Head and neck recurrences are exceedingly rare, making mandibular involvement unusual.\"},{\"question\":\"What symptoms led to discovery of the mandibular lesion?\",\"answer\":\"About two months after completing chemotherapy, the patient developed progressive trismus and left mandibular pain, initially evaluated as a temporomandibular joint disorder. Imaging later revealed a mass in the left mandible.\"},{\"question\":\"What treatment was used for the solitary mandibular recurrence and what was the outcome?\",\"answer\":\"The patient received pembrolizumab and lenvatinib therapy. After treatment, the mandibular tumor was no longer detectable, and the response has been maintained.\"}]","Solitary mandibular recurrence of uterine endometrial carcinoma successfully treated with chemotherapy alone - A case report | PDF",1790739689]