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This study tests whether a smartphone-based patient-caregiver education program lowers 12-week relapse rates in children aged 0–6 with moderate-to-severe AD versus conventional outpatient consultation alone. In 615 children enrolled across 12 centers, the digital education group showed significantly fewer relapses, with better early relapse-free survival. Benefits diminished after 12 weeks while engagement remained high.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/smartphone-based-digital-eczema-education-program-for-atopic-dermatitis-in-children-aged-0-to-6-years-original-paper-multicenter-randomized-parallel-controlled-clinical-study/455346/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/smartphone-based-digital-eczema-education-program-for-atopic-dermatitis-in-children-aged-0-to-6-years-original-paper-multicenter-randomized-parallel-controlled-clinical-study/455346.png","ImageObject",300,407,{"name":92,"@type":93},"hdkawk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main goal of this study?","Question",{"text":113,"@type":114},"To evaluate whether a smartphone-based patient-caregiver educational program can reduce relapse rates in children aged 0 to 6 years with moderate-to-severe atopic dermatitis compared with conventional outpatient consultation alone.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the trial designed and who participated?",{"text":118,"@type":114},"This multicenter, randomized, parallel-controlled trial enrolled 615 children across 12 tertiary pediatric dermatology centers in China and assigned participants 1:1 to either a smartphone-based digital education program plus standard care or conventional face-to-face consultation only.",{"name":120,"@type":111,"acceptedAnswer":121},"Did the digital education program reduce relapses, and for how long?",{"text":122,"@type":114},"Yes. Relapse at 12 weeks occurred less frequently in the digital education group than in the control group (16.6% vs 24.0%). Kaplan-Meier analysis also showed better relapse-free survival during the first 100 days, while differences beyond 12 weeks were not statistically significant.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},455346,1790860896,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},3985747859855,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","JOURNAL OF MEDICAL INTERNET RESEARCH Yang et al  \nOriginal Paper  \nSmartphone-Based Digital Eczema Education Program for Atopic Dermatitis in Children Aged 0 to 6 Years: Multicenter, Randomized, Parallel Controlled Clinical Study  \n\n| Huan Yang 1* , MD, PhD; Hong Shu2* , MD; Liu-hui Wang3* , MD; Ping Li4* , MD, PhD; Yun-ling Li5 , MD; Qin-feng Li6 , MD; Xiu-ping Han7 , MD; Jing Tian8 , MD; Jing Chang9 , MD; Hua Qian10 , MD, PhD; Jing-ping Chen 11 , MM; Xin-qiang Ding 12 , MD; Pan-qian Wu2 , MD; Li-min Dou3 , MD; Zhen Luo4 , MD; Wei Li5 , MM; Yang-yang Lin6 , MD; Lin Li7 , MD; Shu-zhen Yue9 , MD; Yang Gu10 , MM; Li Yang11 , MD; Xiao-hong Sun 12 , MD; Xiao-yan Luo 1* , MD, PhD; Lin Ma8* , MD, PhD; Hua Wang 1* , MD, PhD |\n| --- |\n| 1Department of Dermatology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China\u003Cbr>2Department of Dermatology, Kunming Children's Hospital, Kunming, China 3Department of Dermatology, Children’s Hospital of Fudan University, Shanghai, China 4Department of Dermatology, Shenzhen Children’s Hospital, Shenzhen, China\u003Cbr>5Department of Dermatology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center of Child Health, Hangzhou, China\u003Cbr>6Department of Dermatology, Tianjin Children’s Hospital, Tianjin, China\u003Cbr>7Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, China\u003Cbr>8Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China 9Department of Dermatology, Hunan Children's Hospital, Changsha, China\u003Cbr>10Department of Dermatology, Children’s Hospital of Soochow University, Suzhou, China 11Department of Dermatology, Guangzhou Woman and Children’s Medical Center, Guangzhou, China 12Department of Dermatology, Xi'an Children's Hospital, Xi'an, China\u003Cbr>*these authors contributed equally\u003Cbr>Corresponding Author:\u003Cbr>Hua Wang, MD, PhD\u003Cbr>Department of Dermatology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders\u003Cbr>Ministry of Education Key Laboratory of Child Development and Disorders NO.136 Zhongshan 2nd Road, Yuzhong District\u003Cbr>Chongqing 400014 China\u003Cbr>Phone: +86-23-63638830\u003Cbr>[Email:](Email: huawang@hospital.cqmu.edu.cn)[ ](Email: huawang@hospital.cqmu.edu.cn)[huawang@hospital.cqmu.edu.cn](Email: huawang@hospital.cqmu.edu.cn)\u003Cbr>Abstract |\n\nBackground: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition that affects approximately 10% to 20% of children, imposing substantial health and economic burdens. Although education for patients and caregivers is acknowledged as a crucial element in the management of AD, conventional approaches, such as workshops or in-person consultations, are often resource intensive and face challenges related to scalability, personalization, and relapse prevention. Digital tools present promising alternatives; however, empirical evidence supporting their effectiveness in young children is currently limited.  \nObjective: This study aimed to evaluate whether a smartphone-based patient-caregiver educational program could reduce relapse rates in children aged 0 to 6 years with moderate-to-severe AD, compared with conventional outpatient consultation alone.  \nMethods: In this multicenter, randomized, parallel-controlled trial, 615 children were enrolled across 12 tertiary pediatric dermatology centers in China and randomized (1:1) to receive either a smartphone-based digital education program with standard care (intervention group) or conventional face-to-face consultation only (control group) . The 12-week digital  \n[https://www.jmir.org/2026/1/e79559](https://www.jmir.org/2026/1/e79559) J Med Internet Res 2026 | vol. 28 | e79559 | p. 1  \n(page number not for citation purposes)  \nJOURNAL ","cbCaib6Ldpqv5AZM","https://ap.wps.com/l/cbCaib6Ldpqv5AZM","pdf",658368,13,"English","# Abstract\n## Background\n## Objective\n## Methods\n## Results\n## Conclusions\n## Trial Registration","[{\"question\":\"What is the main goal of this study?\",\"answer\":\"To evaluate whether a smartphone-based patient-caregiver educational program can reduce relapse rates in children aged 0 to 6 years with moderate-to-severe atopic dermatitis compared with conventional outpatient consultation alone.\"},{\"question\":\"How was the trial designed and who participated?\",\"answer\":\"This multicenter, randomized, parallel-controlled trial enrolled 615 children across 12 tertiary pediatric dermatology centers in China and assigned participants 1:1 to either a smartphone-based digital education program plus standard care or conventional face-to-face consultation only.\"},{\"question\":\"Did the digital education program reduce relapses, and for how long?\",\"answer\":\"Yes. Relapse at 12 weeks occurred less frequently in the digital education group than in the control group (16.6% vs 24.0%). Kaplan-Meier analysis also showed better relapse-free survival during the first 100 days, while differences beyond 12 weeks were not statistically significant.\"}]","Smartphone-Based Digital Eczema Education Program for Atopic Dermatitis in Children Aged 0 to 6 Years - Original Paper - Multicenter, Randomized, Parallel Controlled Clinical Study | PDF",1790742661,33]