[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-339592-105":59,"doc-detail-339592-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","smart-nanoplatforms-review-precise-drug-delivery-in-cancer-therapy","Smart Nanoplatforms - Review - Precise Drug Delivery in Cancer Therapy","","The tumor microenvironment (TME) is a complex, dynamic system of stromal cells, immune cells, blood vessels and extracellular matrix, strongly linked to cancer initiation, progression, and treatment response. This review explains how tumor-shared traits—acidic conditions, enzymes, and hypoxia—enable responsive, nano-loaded drug release targeted to tumor tissues or cells. It surveys TME-responsive nanoplatform designs (acidic pH, high GSH, high ATP, overexpressed enzymes, hypoxia and reductive environments) and highlights emerging TME-responsive nanoparticles. 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It is closely associated with cancer occurrence, development, and therapy response.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do TME-responsive nanoplatforms enable precise drug delivery?",{"text":117,"@type":113},"They exploit tumor-specific conditions such as acidic pH, high GSH, high ATP, enzyme overexpression, hypoxia, and reductive environments. This allows targeted accumulation, penetration, endocytosis facilitation, and controlled drug release.",{"name":119,"@type":110,"acceptedAnswer":120},"What advancements and future outlook does the review emphasize?",{"text":121,"@type":113},"The review showcases latest developments in TME-responsive nanoparticles and discusses immediate challenges and prospects. 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Utilizing the shared characteristics of tumors, such as an acidic environment, enzymes and hypoxia, researchers have developed a promising cancer therapy strategy known as responsive release of nano-loaded drugs, specifically targeted at tumor tissues or cells. In this comprehensive review, we provide an in-depth overview of the current fundamentals and state-of-the-art intelligent strategies of TME-responsive nanoplatforms, which include acidic pH, high GSH levels, high-level adenosine triphosphate, overexpressed enzymes, hypoxia and reductive environment. Additionally, we showcase the latest advancements in TME-responsive nanoparticles. In conclusion, we thoroughly examine the immediate challenges and prospects of TME-responsive nanopharmaceuticals, with the expectation that the progress of these targeted nanoformulations will enable the exploitation, overcoming or modulation of the TME, ultimately leading to significantly more effective cancer therapy.\u003Cbr>Keywords: tumor microenvironment, stimulus-responsive, drug delivery, cancer therapy, intelligent biomedicine |\n| --- |\n| Introduction\u003Cbr>Malignant tumors are a leading cause of human mortality. In recent years, significant advancements have been made in tumor therapy, thanks to the development of various approaches. Notably, nanotechnology and targeted drug delivery systems have garnered considerable attention due to the favorable characteristics of nanoparticles, such as excellent permeability, enhanced loading capacity and high specificity. Consequently, nanoparticles have become widely adopted as effective carriers for delivering chemotherapeutic drugs, nucleic acids and genes to precise target sites for the treatment of oncological diseases. The tumor microenvironment (TME) plays a pivotal role in tumor development, consisting of tumor cells, tumor stromal cells, the extracellular matrix, as well as various cytokines and chemokines (Figure 1) .1–5 Compared to the normal human internal environment, the TME exhibits distinct biochemical properties, including hypoxia, acidity, strong redox characteristics, abnormal enzyme metabolism, and immunosuppression.6 Of particular interest in recent research on nano-targeted agents are the weak acidic and strong redox properties, given their significant roles in tumor progression, metastasis and immune evasion.7 Metabolic differences between cancer cells and normal cells contribute to unique features within th","cbCaiuJhgrIcRj2Q","https://ap.wps.com/l/cbCaiuJhgrIcRj2Q","pdf",9035457,25,"English","# Abstract\n# Introduction\n# Received, Accepted, Published Information\n# Graphical Abstract","[{\"question\":\"What is the tumor microenvironment (TME) and why is it important?\",\"answer\":\"The TME is a complex, dynamic entity involving stromal cells, immune cells, blood vessels and extracellular matrix. It is closely associated with cancer occurrence, development, and therapy response.\"},{\"question\":\"How do TME-responsive nanoplatforms enable precise drug delivery?\",\"answer\":\"They exploit tumor-specific conditions such as acidic pH, high GSH, high ATP, enzyme overexpression, hypoxia, and reductive environments. This allows targeted accumulation, penetration, endocytosis facilitation, and controlled drug release.\"},{\"question\":\"What advancements and future outlook does the review emphasize?\",\"answer\":\"The review showcases latest developments in TME-responsive nanoparticles and discusses immediate challenges and prospects. The goal is to improve exploitation, overcoming, or modulation of the TME for more effective cancer therapy.\"}]","Smart Nanoplatforms - Review - Precise Drug Delivery in Cancer Therapy | PDF",1790031151,63]