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Evidence suggests that perimenopause, a major endocrine transition, negatively affects the female brain and may contribute to the higher dementia risk. This study addresses a gap in randomized trials by evaluating resistance training for midlife brain health. In a pilot of 35 perimenopausal and early postmenopausal participants, 9 months of 2x/week training improved cognitive flexibility versus waitlist, with favorable but non-significant gains in other cognitive domains.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/smart-brain-study-of-menopause-and-resistance-training-on-brain-health-s2-abstract-citation-igaf1221802/426654/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/smart-brain-study-of-menopause-and-resistance-training-on-brain-health-s2-abstract-citation-igaf1221802/426654.png","ImageObject",300,407,{"name":92,"@type":93},"Danger Angel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why focus on females and perimenopause for dementia risk?","Question",{"text":112,"@type":113},"Females make up two-thirds of dementia cases and have a two-fold greater lifetime risk. Perimenopause is described as a key endocrine transition that negatively impacts the female brain and may contribute to this higher risk.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What resistance training intervention was used in the pilot study?",{"text":117,"@type":113},"A 2x/week resistance training program was delivered for 9 months to 35 perimenopausal and early postmenopausal participants.",{"name":119,"@type":110,"acceptedAnswer":120},"Which cognitive outcome improved significantly?",{"text":121,"@type":113},"Compared with the waitlist control group, cognitive flexibility improved significantly in the intervention group.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426654,1790778367,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},962090769052,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Innovation in Aging, 2025, Vol. 9, No. S2 527  \nAbstract citation ID: igaf122.1802  \nSMART BRAIN: STUDY OF MENOPAUSE AND  \nRESISTANCE TRAINING ON BRAIN HEALTH  \nCindy Barha, University of Calgary, Calgary, Alberta, Canada  \nTwo-thirds of all persons with dementia are females and females have a 2-fold greater lifetime risk of developing dementia than males.  \nExercise is a promising lifestyle intervention for promotion of cognitive function.We have shown that this is particularly true for older, postmenopausal females compared with older males. Perimenopause  \n– one of the most significant endocrine transitions in a female’s life  \n– negatively impacts the female brain and is believed to be a key contributor to a female’s greater lifetime risk for dementia. Thus, perimenopause may be a critical window to implement exercise interventions for the promotion of female brain health. There is adearth of randomized controlled trials that examine the impact of exercise of any type on brain health in midlife (i.e., 40 to 60 years of age). Resistance training, specifically, may provide multi-system benefits for females as they transition through menopause. In a small pilot study, 35 perimenopausal and early postmenopausal participants underwent a 2x/week, 9-month resistance training intervention. Cognition was measured with the NIH Toolbox, a valid neuropsychological test battery, and task-induced hemodynamic response in the brain was measured using functional near infrared spectroscopy at baseline and trial-completion. Compared with the waitlist control group, a significant improvement was seen in cognitive flexibility in the intervention group. Non-significant improvements were also seen in the intervention group in processing speed, inhibitory control and verbal episodic memory delayed recall. These findings indicate that resistance training is a promising intervention for promoting cognition in midlife.","cbCaigcf0FfKwSiw","https://ap.wps.com/l/cbCaigcf0FfKwSiw","pdf",493883,"English","# Abstract\n## Background and rationale\n## Study design and measures\n## Results and implications","[{\"question\":\"Why focus on females and perimenopause for dementia risk?\",\"answer\":\"Females make up two-thirds of dementia cases and have a two-fold greater lifetime risk. Perimenopause is described as a key endocrine transition that negatively impacts the female brain and may contribute to this higher risk.\"},{\"question\":\"What resistance training intervention was used in the pilot study?\",\"answer\":\"A 2x/week resistance training program was delivered for 9 months to 35 perimenopausal and early postmenopausal participants.\"},{\"question\":\"Which cognitive outcome improved significantly?\",\"answer\":\"Compared with the waitlist control group, cognitive flexibility improved significantly in the intervention group.\"}]","SMART BRAIN: STUDY OF MENOPAUSE AND RESISTANCE TRAINING ON BRAIN HEALTH - S2 - Abstract citation igaf122.1802 | PDF",1790641312]