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Literature reports snoRNAs as commonly overexpressed regulators of invasion, proliferation, apoptosis, and migration, linked to prognosis such as metastasis and poorer survival.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/small-nucleolar-rnas-in-solid-tumors-a-brief-review-of-the-literature-on-these-potential-biomarkers/331438/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/small-nucleolar-rnas-in-solid-tumors-a-brief-review-of-the-literature-on-these-potential-biomarkers/331438.png","ImageObject",300,407,{"name":42,"@type":43},"Sage","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-16","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main objective of this integrative review?","Question",{"text":63,"@type":64},"To summarize key findings, biological functions, and clinical significance of snoRNAs as potential biomarkers in solid tumors.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were relevant sources and gene information collected?",{"text":68,"@type":64},"PubMed and ScienceDirect were searched using keywords; 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Methods: This document analyzes the main data on the involvement of snoRNAs in solid tumors. For this, Pubmed and Science direct were used, with keywords. Additionally, a search for the host gene was conducted using the snoDB tool, and its chromosomal location was identified using the Hugo Gene Nomenclature Committee (HGNC). Results: According to research conducted in the literature, the majority of snoRNAs were found to be overexpressed and described as regulators of processes such as invasion, cellular proliferation, apoptosis, and migration. They are associated with clinical prognostic factors such as metastasis and worse survival. Conclusion: Therefore, it is essential to expand the investigation of snoRNAs in oncology across different types of tumors. The utilization of these biomolecules may pave the way for innovative clinical applications, such as their use in the early detection of neoplasms in non-invasive samples and as therapeutic targets. Broadening research on snoRNAs across various tumor types is crucial.  \nKeywords: Biological function-biomarker-cancer-clinical significance-snoRNAs  \nAsian Pac J Cancer Prev, 25 (8), 2585-2591  \nIntroduction  \nSolid tumors are considered one of the leading causes of cancer-related deaths, due to their rapid tumor growth and local or distant metastasis. They pose critical challenges due to physiological characteristics and limitations in treatment options [1, 2]. Among the markers that have been extensively studied in these types of tumors are non coding RNAs (ncRNAs) . There are several families of ncRNAsin mammals, some of which are: microRNAs (miRNAs), small interfering RNAs (siRNAs), piwi-interacting RNAs (piRNAs), transfer RNAs (tRNAs) and small nucleolar RNAs (snoRNAs) [3] .  \nsnoRNAs have an average size of 60-70 nucleotides (nt) and are widely distributed in the nucleolus of eukaryotic cells [4] . snoRNAs do not have a poly-A tail and are 5′-capped. While this modification is typical for their nuclear localization, it does not necessarily mean they are not exported from the nucleus. They can  \nbe divided into two subtypes, according to the motif present in the molecule: H/ACA (SNORA) and C/D box (SNORD) . A third group is the SCARNA, discovered in 2002, which has presents both C/D and H/ACA domainsand accumulates in Cajal bodies [5] . In vertebrates, most snoRNAs are encoded in intronic regions of coding genes or long non-coding RNAs (lncRNAs), and a small group of snoRNAs originate from intergenic regions [6] .  \nSince their discovery, the functional role ofsnoRNAsunder normal and pathological conditions has been investigated. SnoRNA expression can be modified by a variety of genetic alterations changes such as: a) overexpression; b) translocation; c) mutations; and d) copy number variations [7] . Epigenetic mechanisms can also alter gene expression such as: a) DNA methylation; and b) histone modification [7, 8]. Historically, the first snoRNAassociated human disease described is Prader-Willi syndrome (PWS), a rare genetic disorder characterized by hypotonia and hyperphagia [9, 10] . Currently, snoRNAs  \n1State University of Maranhão, Zé Doca, MA, Brazil. 2Oncology Research Center, Federal University of Pará, Belém, Pará, Brazil. 3La","cbCaiufRWAKlNfIm","https://ap.wps.com/l/cbCaiufRWAKlNfIm","pdf",438875,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n## snoRNAs: size, structure, and subtypes\n## snoRNA regulation and disease relevance\n# Snornas in Lung Cancer","[{\"question\":\"What is the main objective of this integrative review?\",\"answer\":\"To summarize key findings, biological functions, and clinical significance of snoRNAs as potential biomarkers in solid tumors.\"},{\"question\":\"How were relevant sources and gene information collected?\",\"answer\":\"PubMed and ScienceDirect were searched using keywords; snoDB was used to identify host genes, and HGNC was used to determine chromosomal locations.\"},{\"question\":\"What overall biological and clinical patterns are reported for snoRNAs in solid tumors?\",\"answer\":\"Most snoRNAs are described as overexpressed and as regulators of processes such as invasion, proliferation, apoptosis, and migration, with links to prognostic factors like metastasis and worse survival.\"}]","Small Nucleolar RNAs in Solid Tumors - A Brief Review of the Literature on These Potential Biomarkers | PDF",1789993258,18]