[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330659-105":59,"doc-detail-330659-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","small-nucleolar-rnas-as-diagnostic-and-prognostic-biomarkers-in-cancer-a-systematic-review-and-meta-analysis","Small Nucleolar RNAs as Diagnostic and Prognostic Biomarkers in Cancer - A Systematic Review and Meta-Analysis","","Small nucleolar RNAs (snoRNAs) cluster in the genome and represent a category of small noncoding RNAs. Aberrant snoRNA expression has been linked to multiple cancers, and recent work suggests snoRNAs may function as diagnostic and prognostic biomarkers. A systematic search through major databases up to December 30, 2022 included 49 articles, pooling diagnostic accuracy and survival effects using odds ratios, confidence intervals, and hazard ratios. Findings show AUC 0.85, sensitivity 75%, and specificity 80%, with snoRNAs supporting diagnosis and overall survival associations across cancer types.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/small-nucleolar-rnas-as-diagnostic-and-prognostic-biomarkers-in-cancer-a-systematic-review-and-meta-analysis/330659/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/small-nucleolar-rnas-as-diagnostic-and-prognostic-biomarkers-in-cancer-a-systematic-review-and-meta-analysis/330659.png","ImageObject",300,407,{"name":92,"@type":93},"Eliana","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main objective of this systematic review?","Question",{"text":112,"@type":113},"To evaluate whether small nucleolar RNAs (snoRNAs) can serve as diagnostic and prognostic biomarkers across different cancer types, especially given the lack of comprehensive prior reviews on both aspects together.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which search databases and time frame were used?",{"text":117,"@type":113},"The review searched Google Scholar, Medline, Cochrane, Scopus, PubMed, Embase, ScienceDirect, Ovid-Medline, CNKI, WanFang, and SinoMed up to December 30, 2022.",{"name":119,"@type":110,"acceptedAnswer":120},"What diagnostic performance did the pooled analysis report?",{"text":121,"@type":113},"The pooled results reported AUC 0.85, sensitivity 75%, and specificity 80% for cancer diagnosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330659,1790194728,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","Small Nucleolar RNAs as Diagnostic and Prognostic Biomarkers in Cancer: A Systematic Review and Meta-Analysis  \nLiyun Gao, PhD 1,2 , Junfei Fan, MS3, Jiayin He, MS4, Xiangxin Che, PhD 1,  \nXin Wang, MD 1, and Chunhua Han, MS5  \nTechnology in Cancer Research & Treatment  \nVolume 23: 1-13  \n© The Author(s) 2024  \nArticle reuse guidelines: [sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/15330338241245939](DOI: 10.1177/15330338241245939)[ ](DOI: 10.1177/15330338241245939)[journals.sagepub.com/home/tct](journals.sagepub.com/home/tct)  \nAbstract  \nObjectives: Small nucleolar RNAs (snoRNAs) form clusters within the genome, representing a mysterious category of small noncoding RNAs. Research has demonstrated that aberrant snoRNAs can contribute to the development of various types of cancers. Recent studies have identified snoRNAs as potentially valuable biomarkers for the diagnosis or/and prognosis of cancers. However, there has been a lack of comprehensive reviews on prognostic and diagnostic snoRNAs across different types of cancers. Methods: We conducted a systematic search of various databases including Google Scholar, Medline, Cochrane, Scopus, PubMed, Embase, ScienceDirect, Ovid-Medline, Chinese National Knowledge Infrastructure, WanFang, and SinoMed with a time frame reception to December 30, 2022. A total of 49 relevant articles were included in our analysis, consisting of21articles focusing on diagnostic aspects and 41 articles focusing on prognostic aspects. Pooled odds ratio, 95% confidence intervals (CIs), and hazard ratio (HR) were utilized to evaluate clinical parameters and overall survival (OS), respectively. Result: The findings indicated that area under the curve, sensitivity, and specificity were 0.85, 75%, and 80% in cancer, respectively. There was a possibility that snoRNAs had a positive impact on the diagnosis (risk ratio, RR = 2.95, 95% CI: 2.75-3.16, P = 0.000) and OS (HR = 1) in cancer. Additionally, abnormally expressed snoRNAs were associated with a positive impact on OS time for chronic lymphocytic leukemia (HR: 0.88, 95%Cl: 0.69-1.11, P \u003C 0.00001), colon adenocarcinoma (HR: 0.97, 95%Cl: 0.91-1.03, P \u003C0.0001), and ovarian cancer (HR: 0.98, 95%Cl: 0.98-0.99, P \u003C 0.00001). However, dysregulated snoRNAs of colon cancer and colorectal cancer had a negative impact on OS time (HR = 3.01 and 1.01 respectively, P \u003C0.0001). Conclusion: The results strongly suggested that snoRNAs could serve as potential novel indicators for prognosis and diagnosis in cancers. This systematic review followed the guidelines of the Transparent Reporting of Systematic Review and Meta-Analyses (PROSPERO register: CRD42020209096).  \nKeywords  \nsmall nucleolar RNA, diagnosis, prognosis, sensitivity, specificity, hazard ratio  \nAbbreviations  \nACC, adrenocortical carcinoma; BRCA, breast cancer; CC, colon cancer; ccRCC, cell renal cell carcinoma; CLL, chronic lymphocytic leukemia; COAD, colon adenocarcinoma; CRC, colorectal cancer; GBC, gallbladder cancer; GC, gastric cancer;  \n1 Laboratory of Precision Preventive Medicine, School of Basic Medicine, Jiujiang University, Jiujiang, China  \n2 Jiangxi Provincial Key Laboratory of Cell Precision Therapy, School of Basic Medical Sciences, Jiujiang University, China  \n3 School of Humanities, Shangluo University, Shangluo, China  \n4 School of Literature and Journalism, South-central Minzu University, Wuhan, China  \n5 Internal Medicine, Jiujiang First People’s Hospital, Jiujiang, China  \nCorresponding Authors:  \nLiyun Gao, School of Basic Medicine, Jiujiang University, 55 Qianjin Road, Jiujiang, 332005, China  \nEmail: [gaoliyun813@126.com](gaoliyun813@126.com)  \nChunhua Han, Internal Medicine, Jiujiang First People’s Hospital, Gantang Street, Jiujiang, 332005, China  \nEmail: [642300931@qq.com](642300931@qq.com)  \nCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-N","cbCaibQhLkcGt9wK","https://ap.wps.com/l/cbCaibQhLkcGt9wK","pdf",2681686,13,"English","# Abstract\n## Objectives\n## Methods\n## Results\n## Conclusion","[{\"question\":\"What was the main objective of this systematic review?\",\"answer\":\"To evaluate whether small nucleolar RNAs (snoRNAs) can serve as diagnostic and prognostic biomarkers across different cancer types, especially given the lack of comprehensive prior reviews on both aspects together.\"},{\"question\":\"Which search databases and time frame were used?\",\"answer\":\"The review searched Google Scholar, Medline, Cochrane, Scopus, PubMed, Embase, ScienceDirect, Ovid-Medline, CNKI, WanFang, and SinoMed up to December 30, 2022.\"},{\"question\":\"What diagnostic performance did the pooled analysis report?\",\"answer\":\"The pooled results reported AUC 0.85, sensitivity 75%, and specificity 80% for cancer diagnosis.\"}]","Small Nucleolar RNAs as Diagnostic and Prognostic Biomarkers in Cancer - A Systematic Review and Meta-Analysis | PDF",1789989666,33]