[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-342768-105":59,"doc-detail-342768-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","small-molecule-inhibitors-targeting-m6a-regulators-review","Small molecule inhibitors targeting m6A regulators - review","","N6-methyladenosine (m6A) is the most common epigenetic RNA modification and is tightly linked to growth, development, stem cell renewal and differentiation, and DNA damage responses. Aberrant m6A expression in cancer promotes malignant tumor development and contributes to proliferation, metastasis, drug resistance, immunity, and prognosis. Small-molecule agents have emerged to target m6A regulators, enabling precise RNA-modification intervention and disrupting tumor cell survival. A comprehensive review summarizes m6A regulator classification and functions, their roles across common cancers, and the development, mechanisms, pharmacology, and structure-activity relationships of small molecules, aiming to guide future drug design and optimization.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/small-molecule-inhibitors-targeting-m6a-regulators-review/342768/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/small-molecule-inhibitors-targeting-m6a-regulators-review/342768.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the biological significance of m6A in RNA regulation?","Question",{"text":112,"@type":113},"m6A is a dynamic, reversible epigenetic RNA modification that affects key physiological processes including growth, development, stem cell renewal, differentiation, and DNA damage responses.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How are m6A regulators classified and what roles do they play?",{"text":117,"@type":113},"m6A regulation is mediated by three enzyme types: Writers (methyltransferases), Erasers (demethylases), and Readers that recognize m6A-modified mRNAs and trigger downstream reactions.",{"name":119,"@type":110,"acceptedAnswer":120},"Why are small molecules targeting m6A regulators considered for cancer treatment?",{"text":121,"@type":113},"Small molecules can modulate m6A regulation at the epigenetic level, enabling precise intervention in RNA modifications and interfering with tumor-cell survival mechanisms.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},342768,1790168312,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Feng et al. Journal of Hematology & Oncology (2024) 17:30 [https://doi.org/10.1186/s13045-024-01546-5](https://doi.org/10.1186/s13045-024-01546-5)  \nJournal of Hematology & Oncology  \n REVIEW Open Access  \nSmall molecule inhibitors targeting m6A  \nregulators  \nGuotai Feng1†, Yongya Wu1†, Yuan Hu1,2†, Wen Shuai1, Xiao Yang1, Yong Li1*, Liang Ouyang1* and Guan Wang1*  \nAbstract  \nAs the most common form of epigenetic regulation by RNA, N6 methyladenosine (m6A) modification is closely involved in physiological processes, such as growth and development, stem cell renewal and differentiation, and DNA damage response. Meanwhile, its aberrant expression in cancer tissues promotes the development of malignant tumors, as well as plays important roles in proliferation, metastasis, drug resistance, immunity and prognosis. This close association between m6A and cancers has garnered substantial attention in recent years. An increasing number of small molecules have emerged as potential agents to target m6A regulators for cancer treatment. These molecules target the epigenetic level, enabling precise intervention in RNA modifications and efficiently disrupting the survival mechanisms of tumor cells, thus paving the way for novel approaches in cancer treatment. However, there is currently a lack of a comprehensive review on small molecules targeting m6A regulators for anti-tumor. Here, we have comprehensively summarized the classification and functions of m6A regulators, elucidating their interactions with the proliferation, metastasis, drug resistance, and immune responses in common cancers. Furthermore, we have provided a comprehensive overview on the development, mode of action, pharmacology and structure–activity relationships of small molecules targeting m6A regulators. Our aim is to offer insights for subsequent drug design and optimization, while also providing an outlook on future prospects for small molecule development targeting m6A.  \nKeywords N6-methyladenosine, Cancer therapy, Mechanism, Drug targets, Small molecule modulators  \n†Guotai Feng, Yongya Wu, and Yuan Hu have contributed equally to this work.  \n*Correspondence:  \nYong Li[liyong562@scu.edu.cn](liyong562@scu.edu.cn)[ ](liyong562@scu.edu.cn)Liang Ouyang[ouyangliang@scu.edu.cn](ouyangliang@scu.edu.cn)[ ](ouyangliang@scu.edu.cn)Guan Wang [guan8079@scu.edu.cn](guan8079@scu.edu.cn)  \n1 Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, West China Hospital, and West China Second Hospital, Sichuan University /West China School of Nursing, Sichuan University, Chengdu 610041, China  \n2 Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China  \nIntroduction  \nAmong the modification approaches of epigenetics, methylation and demethylation modifications occupy an important position, with N6 methyladenosine (m6A) being the most common post-transcriptional RNA modification in eukaryotes [1]. As a dynamic and reversible epigenetic regulatory mechanism, m6A modification refers to the addition of a methyl group to the 6th nitrogen atom of adenine. It is widely expressed in RNA and mainly occurs at the RRACH sequence (R = A/G, H = A/C/U) near the stop codon and 3 ’- untranslated regions (3’-UTRs). M6A modification is mainly regulated by three enzymes, which are Writers (such as METTL3/14) that mediate methylation, Erasers (such as FTO) that mediate demethylation, and Readers (such as YTHDF1) that recognize and bind mRNAs with m6A modification and thus mediate downstream reactions [2].  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the","cbCaivTdP139Zyv9","https://ap.wps.com/l/cbCaivTdP139Zyv9","pdf",5480353,45,"English","# Introduction\n# Abstract\n# Keywords","[{\"question\":\"What is the biological significance of m6A in RNA regulation?\",\"answer\":\"m6A is a dynamic, reversible epigenetic RNA modification that affects key physiological processes including growth, development, stem cell renewal, differentiation, and DNA damage responses.\"},{\"question\":\"How are m6A regulators classified and what roles do they play?\",\"answer\":\"m6A regulation is mediated by three enzyme types: Writers (methyltransferases), Erasers (demethylases), and Readers that recognize m6A-modified mRNAs and trigger downstream reactions.\"},{\"question\":\"Why are small molecules targeting m6A regulators considered for cancer treatment?\",\"answer\":\"Small molecules can modulate m6A regulation at the epigenetic level, enabling precise intervention in RNA modifications and interfering with tumor-cell survival mechanisms.\"}]","Small molecule inhibitors targeting m6A regulators - review | PDF",1790048122,113]