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Lung and breast cancer are the most frequent primary donors, and most lung-to-meningioma metastases involve lung adenocarcinoma. Only three prior reports describe small-cell lung cancer with this spread pattern. A 67-year-old patient developed a small-cell lung cancer metastasis to a meningioma.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/small-cell-lung-cancer-metastasis-to-meningioma-case-report-and-review-of-the-literature/384446/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/small-cell-lung-cancer-metastasis-to-meningioma-case-report-and-review-of-the-literature/384446.png","ImageObject",300,407,{"name":92,"@type":93},"CatatanPagi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-28","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is tumor-to-tumor metastasis in this article?","Question",{"text":112,"@type":113},"It is metastatic spread where a donor tumor disseminates hematogenously into a recipient tumor. The paper contrasts this with collision tumors where two histologically distinct tumors grow into each other within the same organ.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is meningioma an important recipient tumor in tumor-to-tumor metastasis?",{"text":117,"@type":113},"Meningioma accounts for about 20% of reported tumor-to-tumor metastasis cases. The article notes that breast and lung cancers are the most common donor tumors in these reports.",{"name":119,"@type":110,"acceptedAnswer":120},"What did imaging and biopsy show in the presented case?",{"text":121,"@type":113},"Chest CT revealed a large left upper lung mass with multiple bilateral non-calcified pulmonary nodules. CT-guided biopsy and immunohistochemistry supported small-cell lung cancer, and brain MRI did not show parenchymal brain metastases while an extra-axial mass compatible with meningioma was identified.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},384446,1790363528,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090894170,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Radiology Ca s e Reports 18 (2023) 1452 – 1456  \nAvailable online [at](at www.sciencedirect.com)[ www.sciencedirect.com](at www.sciencedirect.com)  \njournal [homepage:](homepage: www.elsevier.com/locate/radcr)[ www.elsevier.com/locate/radcr](homepage: www.elsevier.com/locate/radcr)  \n| Case Report\u003Cbr>Small-cell lung cancer metastasis to ameningioma: Case report and review of the literature ✩,✩✩,★\u003Cbr>Loukas A. Georgiou, BSa,∗, Jeremiah H. Wright, MDb, Thomas O. Markel, MDc, Paul J. Sims, MDd\u003Cbr>a Kentucky College of Osteopathic Medicine, 147 Sycamore St., Pikeville, KY 41501, USA b Department of Radiology, Jackson-Madison County General Hospital, Jackson, TN, USAc Department of Radiology, Radia Inc., Legacy Salmon Creek Medical Center, Vancouver, WA, USA d Department of Pathology, Jackson-Madison County General Hospital, Jackson, TN, USA |  |  |\n| --- | --- | --- |\n| a r t i c l e i n f o |  | a b s t r a c t |\n| Article history:\u003Cbr>Received 29 December 2022 Revised 7 January 2023 Accepted 9 January 2023 |  | Tumor-to-tumor metastasis is a rare event with meningioma as the recipient tumor accounting for 20% of the reported cases. The most common primary cancers showing this phenomenon are lung and breast cancer. Most lung cancers metastasizing to a meningioma are due to lung adenocarcinoma with the literature containing only 3 prior reports of small-cell lung cancer showing this pattern of spread. Herein, we present the case of a 67-year-old-patient with small-cell lung cancer that developed a metastasis to ameningioma.\u003Cbr>© 2023 The Authors. Published by Elsevier Inc. on behalf of University of Washington.\u003Cbr>This is an open access article under the CC BY-NC-ND license\u003Cbr>([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)) |\n| Keywords:\u003Cbr>Lung neoplasm\u003Cbr>Meningioma\u003Cbr>Tumor-to-tumor metastasis Small-cell |  |  |\n\nIntroduction  \nTwo tumors coexisting in a single location is a rare phenomenon and occurs due to either a tumor-to-tumor metastasis or in a collision tumor. Unfortunately, although the 2  \nmodes of tumor growth are distinct, the 2 terms are often inappropriately used interchangeably. Tumor-to-tumor metastatic spread occurs when a donor tumor showshematogenous metastatic spread to a recipient tumor. A collision tumor consists of 2 histologically distinct tumors localized within a single organ growing into each other.  \n✩ Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.  \n✩✩ Name of Department and Institution Where Work Was Done: Department of Radiation Oncology, Carl Kirkland Cancer Center, Jackson, TN, USA.  \n★ Funding: None.  \n∗ Corresponding author.  \nE-mail address: [loukasgeorgiou@upike.edu](loukasgeorgiou@upike.edu) (L.A. Georgiou).  \n[https://doi.org/10.1016/j.radcr.2023.01.040](https://doi.org/10.1016/j.radcr.2023.01.040)  \n1930-0433/© 2023 The Authors. Published by Elsevier Inc. on behalf of University of Washington. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/))  \nFig. 1 – H&E as well as immunohistochemistry staining of the biopsy specimen from the left lung revealed small-cell lung cancer. (A) H&E staining reveals that the tumor is composed of small to medium sized round to oval blue cells with minimal cytoplasm. The nuclei exhibit a “salt and pepper” chromatin pattern with indistinct nucleoli, nuclear molding, smudge artifact, and frequent mitotic figures. Necrosis and individual cell apoptosis is evident (40× magnification). (B) The tumor cells demonstrate immunoreactivity to cytokeratin 8/18 (20× magnification). (C) Immunoreactivity is also seen with CD56 staining (20× magnification) and to (D) synaptophysin (20× magnification). (E) A Ki-67 stain shows a proliferation index of approximately 70%","cbCaiq28deIttXK6","https://ap.wps.com/l/cbCaiq28deIttXK6","pdf",1364612,"English","# Introduction\n# Case presentation\n# Figures and pathology findings\n# Literature background and prior cases\n# Article history and licensing","[{\"question\":\"What is tumor-to-tumor metastasis in this article?\",\"answer\":\"It is metastatic spread where a donor tumor disseminates hematogenously into a recipient tumor. The paper contrasts this with collision tumors where two histologically distinct tumors grow into each other within the same organ.\"},{\"question\":\"Why is meningioma an important recipient tumor in tumor-to-tumor metastasis?\",\"answer\":\"Meningioma accounts for about 20% of reported tumor-to-tumor metastasis cases. The article notes that breast and lung cancers are the most common donor tumors in these reports.\"},{\"question\":\"What did imaging and biopsy show in the presented case?\",\"answer\":\"Chest CT revealed a large left upper lung mass with multiple bilateral non-calcified pulmonary nodules. CT-guided biopsy and immunohistochemistry supported small-cell lung cancer, and brain MRI did not show parenchymal brain metastases while an extra-axial mass compatible with meningioma was identified.\"}]","Small-cell lung cancer metastasis to ameningioma - Case report and review of the literature | PDF",1790263333,13]