[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-362402-105":59,"doc-detail-362402-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","slpi-in-prostate-cancer","SLPI in Prostate Cancer","","Secretory Leukocyte Protease Inhibitor (SLPI) is a conserved serine protease inhibitor on mucosal surfaces with anti-protease, antimicrobial, and anti-inflammatory roles. SLPI supports tissue homeostasis while also contributing to extracellular matrix remodeling, the tumor microenvironment, and immune regulation that promote tumor progression, including EMT-related processes. SLPI shows context-dependent behavior across cancers: often overexpressed with worse outcomes, yet reduced in some malignancies where higher expression may be favorable. In prostate cancer, SLPI displays bimodal expression—low early, sharply increased in advanced disease and castration-resistant prostate cancer—with elevated levels linked to reduced PSA progression-free survival. This review summarizes multifaceted functions and the clinical relevance in prostate carcinoma.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/slpi-in-prostate-cancer/362402/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/slpi-in-prostate-cancer/362402.png","ImageObject",300,407,{"name":92,"@type":93},"\tJames","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is SLPI and what general functions does it have in the body?","Question",{"text":113,"@type":114},"SLPI is a secretory serine protease inhibitor expressed on mucosal surfaces. It acts as an anti-protease and supports antimicrobial and anti-inflammatory functions, helping maintain tissue homeostasis.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does SLPI behave across different cancers, according to the review?",{"text":118,"@type":114},"SLPI shows a context-dependent, tissue-specific pattern. It is often overexpressed in many cancers and correlates with more advanced, aggressive disease, while it is reduced in some malignancies and may relate to more favorable prognosis in certain contexts.",{"name":120,"@type":111,"acceptedAnswer":121},"What pattern of SLPI expression is described in prostate cancer, and what is its clinical significance?",{"text":122,"@type":114},"In prostate cancer, SLPI levels are low in early stages but become significantly upregulated in advanced and aggressive stages, including castration-resistant prostate cancer. Elevated SLPI levels correlate with reduced PSA progression-free survival.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},362402,1790192893,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":31},2336474466412,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nSLPI in Prostate Cancer  \nDario Rosini 1,2,†, Irene Cosi 1,†, Pierpaolo De Iaco 1,2, Arcangelo Sebastianelli 3,4, Gioia Di Stefano 5,6, Sergio Serni 3,4, Gabriella Nesi 5,6, Rosario Notaro 1, * and Maria De Angioletti 1,7, *  \nAcademic Editor: Emmanuel  \nS. Antonarakis  \nReceived: 22 December 2025  \nRevised: 29 January 2026  \nAccepted: 30 January 2026  \nPublished: 1 February 2026  \nCopyright: © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Laboratory of Cancer Genetics, Core Research Laboratory, Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), 50139 Florence, Italy; [dario.rosini@hotmail.it](dario.rosini@hotmail.it) (D.R.); [irene.cosi90@gmail.com](irene.cosi90@gmail.com) (I.C.); [p.deiaco@student.unisi.it](p.deiaco@student.unisi.it) (P.D.I.)  \n2 Doctorate School GENETICS, ONCOLOGY and CLINICAL MEDICINE (GenOMeC), University of Siena, 53100 Siena, Italy  \n3 Department of Experimental and Clinical Medicine, University of Florence, 50139 Florence, Italy  \n4 Unit of Urological Minimally Invasive, Robotic Surgery and Kidney Transplantation, Careggi Hospital, University of Florence, 50139 Florence, Italy  \n5 Histopathology and Molecular Diagnostic, Careggi University Hospital, 50139 Florence, Italy; [gabriella.nesi@unifi.it](gabriella.nesi@unifi.it) (G.N.)  \n6 Department of Surgery and Translational Medicine, University of Florence, 50139 Florence, Italy  \n7 Istituto di Chimica dei Composti Organometallici (ICCOM)—National Council of Research, Sesto Fiorentino, 50019 Florence, Italy  \n* Correspondence: [r.notaro@ispro.toscana.it](r.notaro@ispro.toscana.it) (R.N.); [maria.deangioletti@iccom.cnr.it](maria.deangioletti@iccom.cnr.it) (M.D.A.)† These authors contributed equally to this work.  \nSimple Summary  \nSLPI is a protein that usually acts as a protective shield for our body’s internal surfaces. Its main jobs are to prevent tissue damage, fight germs, and control inflammation. However, in the context of cancer, SLPI acts like a double-edged sword. While it normally keeps us healthy, many cancers—including lung and breast cancer—hijack this protein to grow and spread more easily. In these cases, high levels of SLPI often signal a more aggressive disease. Interestingly, the opposite happens in some cases, like liver cancer, where more SLPI can bea positive sign. Prostate cancer shows a unique pattern: SLPI protein levels are low in the early stages but rise sharply as the cancer becomes advanced and resistant to treatments. By studying these shifts, scientists can better understand how a tumor behaves, helping doctors predict the disease’s path and develop more effective, personalized treatments for patients.  \nAbstract  \nSecretory Leukocyte Protease Inhibitor (SLPI) is a conserved serine protease inhibitor expressed on mucosal surfaces, which has multiple functions including anti-protease, antimicrobial and anti-inflammatory properties. SLPI plays critical roles in tissue homeostasis and pathology. Through its anti-protease ability, SLPI safeguards tissues from excessive damage caused by proteolytic enzymes released during inflammation and contributes to extracellular matrix remodeling, thereby influencing the cellular and tumor microenvironment. Furthermore, SLPI expression is implicated in shaping the immune landscape that facilitates tumor progression, and in driving epithelial–mesenchymal transition (EMT) . Consequently, it is not surprising that SLPI plays a complex and context-dependent role across various malignancies. It is overexpressed in most cancers such as colorectal, gastric, pancreatic, and breast carcinomas, and this overexpression often correlates with a more advanced and aggressive disease. Conversely, its levels are reduced in head and necksquamous cell carcinoma and hepatocellular carcinoma, where elevated expression maybe associated wit","cbCais48w8nwltj1","https://ap.wps.com/l/cbCais48w8nwltj1","pdf",1363418,"English","# Simple Summary\n# Abstract\n# Keywords\n# 1. Introduction","[{\"question\":\"What is SLPI and what general functions does it have in the body?\",\"answer\":\"SLPI is a secretory serine protease inhibitor expressed on mucosal surfaces. It acts as an anti-protease and supports antimicrobial and anti-inflammatory functions, helping maintain tissue homeostasis.\"},{\"question\":\"How does SLPI behave across different cancers, according to the review?\",\"answer\":\"SLPI shows a context-dependent, tissue-specific pattern. It is often overexpressed in many cancers and correlates with more advanced, aggressive disease, while it is reduced in some malignancies and may relate to more favorable prognosis in certain contexts.\"},{\"question\":\"What pattern of SLPI expression is described in prostate cancer, and what is its clinical significance?\",\"answer\":\"In prostate cancer, SLPI levels are low in early stages but become significantly upregulated in advanced and aggressive stages, including castration-resistant prostate cancer. Elevated SLPI levels correlate with reduced PSA progression-free survival.\"}]","SLPI in Prostate Cancer | PDF",1790147544]