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While SLITRK2 overexpression has been reported in glioma, its expression pattern, prognostic significance, and immunological function across tumors remain unclear in gastric cancer. Methods Integrated analyses used TCGA and GTEx for pan-cancer expression and stage associations; Kaplan–Meier survival evaluated prognostic relevance across 33 cancer types. Immune infiltration, immunomodulatory genes, TMB, MSI, and mutation links were assessed, with validation in 89 paired gastric cancer tissues using TMA.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/slitrk2-as-a-prognostic-and-immunological-biomarker-in-gastric-cancer/332753/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/slitrk2-as-a-prognostic-and-immunological-biomarker-in-gastric-cancer/332753.png","ImageObject",300,407,{"name":92,"@type":93},"Eden","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-10","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is SLITRK2 and why is it studied in cancer?","Question",{"text":112,"@type":113},"SLITRK2 encodes a transmembrane protein that regulates neurite outgrowth. Prior reports suggest links to tumor biology, but its tumor-wide expression, prognostic value, and immune-related functions require clarification.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were SLITRK2 expression patterns and prognostic effects evaluated?",{"text":117,"@type":113},"Expression patterns were analyzed across pan-cancers using TCGA and GTEx, followed by associations with tumor stage. Prognostic relevance was assessed using Kaplan–Meier survival analysis across 33 cancer types.",{"name":119,"@type":110,"acceptedAnswer":120},"What relationship did SLITRK2 show with immune features and gastric cancer outcomes?",{"text":121,"@type":113},"Bioinformatic results indicated SLITRK2 is connected to immune response, with significant associations to immune cell infiltration and immunologic marker expression. In gastric cancer TMA data, SLITRK2 higher expression correlated with poorer survival and features such as lymph node metastasis and advanced AJCC/TNM stage.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332753,1790852494,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374391974468,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Research  \nSLITRK2 as a prognostic and immunological biomarker in gastric cancer  \nHuiqiong Zhu1 · Hailin Xiong1 · Xuli Guo1 · Haojie Liao1 · Shuyi Zhang1  \nReceived: 29 July 2024 / Accepted: 5 November 2024  \n© The Author(s) 2024 OPEN  \nAbstract  \nBackground SLIT and NTRK-like protein 2 (SLITRK2) encodes a transmembrane protein that regulates neurite outgrowth. Some studies have demonstrated that SLITRK2 overexpressed in glioma. But the expression pattern, prognostic value and immunologic function of SLITRK2 in tumors remains unknown.  \nMethods The expression pattern of SLITRK2 among pan-cancers was examined through the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx). We analyzed the association between SLITRK2 expression level and tumor stage among pan-cancers. Kaplan–Meier survival analysis was utilized to investigate the prognostic relevance of SLITRK2 across 33 different types of cancers. Moreover, the correlations among SLITRK2 expression, immune cell infiltration, immunomodulatory related genes, tumor mutation burden (TMB), microsatellite instability (MSI) were evaluated. The relationship between SLITRK2 expression and crucial genes mutations was also illustrated. By using tissue microarray (TMA), the expression of SLITRK2 in 89 paired gastric cancer (GC) tissues was investigated.  \nResults Our study indicated that SLITRK2 expression varied across cancers. Elevated SLITRK2 expression was positively related to advanced tumor stage, poor overall survival (OS) and reduced disease-free survival (DFS). Bioinformatic analyses underscore SLITRK2’s role in immune response, with its expression significantly tied to immune cell infiltration and marker expression. Based on TMA data, SLITRK2 expression level was positively associated with differentiation, lymph node metastasis, AJCC stage, TNM stage, and poor survival outcome in GC patients.  \nConclusion Our findings provided that SLITRK2 may function as a biomarker by regulating immune cell infiltration. In addition, we verified that high SLITRK2 expression was correlated with poor prognosis in GC.  \nKeywords SLITRK2 · Pan-cancer biomarker · Prognosis · Immune cell infiltration · Gastric cancer  \nAbbreviations  \nSLITRK2 SLIT and NTRK-like protein 2  \nTCGA Cancer Genome Atlas  \nGTEx Genotype-Tissue Expression TIMER Tumor Immune Estimation Resource  \nTISIDB Tumor–immune System Interactions and Drug bank GEO Gene Expression Omnibus  \nSupplementary Information The online version contains supplementary material available at [https://doi.org/10.1007/s12672-024-](https://doi.org/10.1007/s12672-024-)[ ](https://doi.org/10.1007/s12672-024-)[01534-8](01534-8.)[.](01534-8.)  \n* Shuyi Zhang, [zhangshuyigdhz@126.com |](zhangshuyigdhz@126.com |1Department of Oncology)[1](zhangshuyigdhz@126.com |1Department of Oncology)[Department of Oncology](zhangshuyigdhz@126.com |1Department of Oncology), Huizhou Central People’s Hospital, Huizhou 516000, Guangdong Province, China.  \n Discover Oncology (2024) 15:667 | [https://doi.org/10.1007/s12672-024-01534-8](https://doi.org/10.1007/s12672-024-01534-8)  \nTMB Tumor mutation burden MSI Microsatellite instability TMA Tissue microarray  \nICIs Immune checkpoint inhibitors IHC Immunohistochemistry  \nOS Overall survival DFS Disease-free survival RFS Relapse free survival HR Hazard ratio  \nTIICs Tumor-infiltrating immune cells CIs Confidence intervals  \nACC Adrenocortical carcinoma BLCA Bladder urothelial carcinoma BRCA Breast invasive carcinoma CESC Cervical squamous cell carcinoma CHOL Cholangiocarcinoma  \nCOAD Colon adenocarcinoma ESCA Esophageal carcinoma  \nHNSC Head and neck squamouscell carcinoma GBM Glioblastoma multiforme  \nKICH Kidney chromophobe  \nKIRC Kidney renal clear cell carcinoma KIRP Kidney renal papillary cell carcinoma LGG Lower grade glioma  \nLIHC Liver hepatocellular carcinoma LUAD Lung adenocarcinoma  \nLUSC Lung squamous cell carcinoma MESO Mesothelioma  \nOV Ovarian serous cystadenocarcinoma PAAD Pancreatic adenocarcinoma  \n","cbCaioueh0Arh1di","https://ap.wps.com/l/cbCaioueh0Arh1di","pdf",9423700,18,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is SLITRK2 and why is it studied in cancer?\",\"answer\":\"SLITRK2 encodes a transmembrane protein that regulates neurite outgrowth. Prior reports suggest links to tumor biology, but its tumor-wide expression, prognostic value, and immune-related functions require clarification.\"},{\"question\":\"How were SLITRK2 expression patterns and prognostic effects evaluated?\",\"answer\":\"Expression patterns were analyzed across pan-cancers using TCGA and GTEx, followed by associations with tumor stage. Prognostic relevance was assessed using Kaplan–Meier survival analysis across 33 cancer types.\"},{\"question\":\"What relationship did SLITRK2 show with immune features and gastric cancer outcomes?\",\"answer\":\"Bioinformatic results indicated SLITRK2 is connected to immune response, with significant associations to immune cell infiltration and immunologic marker expression. In gastric cancer TMA data, SLITRK2 higher expression correlated with poorer survival and features such as lymph node metastasis and advanced AJCC/TNM stage.\"}]","SLITRK2 as a prognostic and immunological biomarker in gastric cancer | PDF",1789999392,45]