[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-428039-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-428039-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","sleep-quality-moderates-age-related-decline-in-hippocampal-dependent-memory-in-midlife-adults","SLEEP QUALITY MODERATES AGE-RELATED DECLINE IN HIPPOCAMPAL-DEPENDENT MEMORY IN MIDLIFE ADULTS","","Hippocampal function is vulnerable to age-related decline, and sleep has been linked to hippocampal integrity and cognition in older adults. This cross-sectional study tested whether sleep quality moderates age-related deterioration in hippocampal-dependent memory during midlife. Data from cognitively normal midlife adults with a family history of Alzheimer’s disease (N=180; age 40–65) were analyzed using PSQI and the Mnemonic Similarity Task (MST), with covariates including sex, education, APOE-ε4, and pulse pressure. A significant Age × PSQI interaction predicted steeper decline in memory performance for poorer sleepers.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/sleep-quality-moderates-age-related-decline-in-hippocampal-dependent-memory-in-midlife-adults/428039/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/sleep-quality-moderates-age-related-decline-in-hippocampal-dependent-memory-in-midlife-adults/428039.png","ImageObject",300,407,{"name":42,"@type":43},"Putri","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What question does this study address about sleep and aging?","Question",{"text":63,"@type":64},"It examines whether sleep quality moderates age-related decline in hippocampal-dependent memory specifically during midlife.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Who participated and how were they assessed?",{"text":68,"@type":64},"Cognitively normal midlife adults with a family history of Alzheimer’s disease (N=180) completed the PSQI and performed the Mnemonic Similarity Task (MST).",{"name":70,"@type":61,"acceptedAnswer":71},"What was the key statistical finding?",{"text":72,"@type":64},"The study found a significant Age × PSQI interaction, indicating poorer sleep quality was associated with steeper age-related decline in hippocampal-dependent memory performance.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},428039,1790693947,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":30},962085571259,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","1256 Innovation in Aging, 2025, Vol. 9, No. S2  \nUnited States, 3. Athens-Clarke County Unified Government, Athens, Georgia, United States, 4. Meharry Medical College, Nashiville, Tennessee, United States, 5. Longwood University, Farmville, Virginia, United States, 6. University of North Carolina at Greensboro, Greensboro, North Carolina, United States  \nThe hippocampus, critical for learning and memory, is vulnerable to age-related decline. Evidence suggests that sleep is associated with hippocampal integrity and cognitive function in older adults. However, few studies have examined whether sleep quality moderates age-related decline in hippocampal-dependent memory in midlife—a critical time point for detecting preclinical cognitive changes. In this cross-sectional study, we tested the hypothesis that poor sleep quality would be linked to steeper age-related decline in hippocampal-dependent memory performance in midlife. We analyzed data from cognitively normal midlife adults with a family history of Alzheimer’s disease (N = 180; Age= 40–65 years [M = 56.13±6.35 years]; 89% females, MoCA=27 .9±1 . 7) enrolled in a clinical trial (NCT03876314) . Participants completed the Pittsburg Sleep Quality Index (PSQI) and Mnemonic Similarity Task (MST)—a sensitive test of hippocampal-dependent memory function. Multiple linear regression was fitted while controlling for potential covariates (e.g., sex, education, APOE-ε4 carriage, and pulse pressure). There was a significant Age × PSQI interaction (b=–0.0017, p=.037) with lure discrimination index (LDI) as the outcome, such that higher PSQI scores (poorer sleep quality) were associated with steeper age-related decline in hippocampal-dependent memory performance. Simple slopes analysis showed that age predicted lower LDI in participants with average (b = −0.01, p=.01) and higher (+1 SD) PSQI (b = −0.01, p\u003C.01), but not those with lower (–1 SD) PSQI (p=.81) . These findings suggest the potential role of sleep quality in protecting hippocampal-dependent memory function against age-related decline in midlife and support the utility of the MST for detecting subtle cognitive changes during this critical life stage.  \nAbstract citation ID: igaf122.4195  \nSLEEP QUALITY MODERATES AGE-RELATED DECLINE  \nIN HIPPOCAMPAL-DEPENDENT MEMORY IN  \nMIDLIFE ADULTS  \nKyoung Shin Park1, Samantha DuBois2, Samuel Kibildis3, Hadassah Som-Pimpong4, Jarod Vance5, Brittany Armstrong6, Christopher Wahlheim6, and Jennifer Etnier6, 1. Emory University School of Medicine, Atlanta, Georgia, United States, 2. Appalachian State University, Boone, North Carolina,","cbCaieZHj4fbWU0q","https://ap.wps.com/l/cbCaieZHj4fbWU0q","pdf",1109369,"English","# Study Background\n# Methods\n## Participants and Measures\n## Statistical Modeling\n# Results\n## Age × PSQI Interaction\n## Simple Slopes Findings\n# Implications","[{\"question\":\"What question does this study address about sleep and aging?\",\"answer\":\"It examines whether sleep quality moderates age-related decline in hippocampal-dependent memory specifically during midlife.\"},{\"question\":\"Who participated and how were they assessed?\",\"answer\":\"Cognitively normal midlife adults with a family history of Alzheimer’s disease (N=180) completed the PSQI and performed the Mnemonic Similarity Task (MST).\"},{\"question\":\"What was the key statistical finding?\",\"answer\":\"The study found a significant Age × PSQI interaction, indicating poorer sleep quality was associated with steeper age-related decline in hippocampal-dependent memory performance.\"}]","SLEEP QUALITY MODERATES AGE-RELATED DECLINE IN HIPPOCAMPAL-DEPENDENT MEMORY IN MIDLIFE ADULTS | PDF",1790645609]