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This review examines how sleep disorders may influence cancer development and progression through altered metabolism, immune response, hormone changes, and gene expression. It summarizes current mechanisms, common sleep complaints, and multimodal clinical treatment approaches, and highlights remaining research needs across cancer tissue and molecular types.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sleep-and-cancer-review/364792/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sleep-and-cancer-review/364792.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the aim of this review on sleep and cancer?","Question",{"text":112,"@type":113},"To summarize current information on sleep issues and their relationship with cancer development and progression, including how cancer can affect sleep and practical treatment options for clinicians.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does this review describe mechanisms linking sleep disorders to cancer?",{"text":117,"@type":113},"It explains links through altered metabolism, effects on immune response, and changes in hormones and gene expression, with sleep disorders potentially arising after or being worsened by cancer and its treatment.",{"name":119,"@type":110,"acceptedAnswer":120},"What does the review conclude about research and treatment?",{"text":121,"@type":113},"It states that significant research is still needed to fully understand the relationship, that effects appear to vary by cancer tissue and molecular type, and that treatment of sleep disorders is multimodal and promising for quality of life.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},364792,1790505313,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","Review  \nSleep and Cancer  \nCourtney M. Vaughn 1 and Bradley V. Vaughn 2, *  \nAcademic Editors: Mitchell  \nS. Fourman and Amanda N. Goldin  \nReceived: 25 January 2025  \nRevised: 3 March 2025  \nAccepted: 4 March 2025  \nPublished: 7 March 2025  \nCitation: Vaughn, C.M.; Vaughn, B.V. Sleep and Cancer. Cancers 2025, 17, 911. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers17060911  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Department of Pediatrics, Division of Pediatric Hematology and Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA; [cmvaughn@wustl.edu](cmvaughn@wustl.edu)  \n2 Department of Neurology, Division of Sleep Medicine, University of North Carolina, Chapel Hill, NC 27599, USA  \n* [Correspondence: vaughnb@neurology.unc.edu](Correspondence: vaughnb@neurology.unc.edu)  \nSimple Summary: Over two-thirds of patients with cancer have an issue with their sleep, and some research indicates that sleep may impact the development and progression of cancer. The aim of this review is to highlight the current information on sleep issues, such as sleep duration, sleep disruption, and sleep disorders, and the development and progression of cancer, as well as the impact of cancer on sleep. This article outlines the common sleep complaints in patients with cancer and discusses a logical approach and treatment options for sleep issues in patients with cancer.  \nAbstract: Background/Objectives: Sleep issues are common in the general population, and these problems occur even more frequently for people with cancer. Sleep problems may pre-exist a patient’s cancer diagnosis, and there is a growing interest in understanding the impact of sleep on cancer development and progression. Sleep disorders may impact cancer through altered metabolism, impacts on immune response, and alterations in hormones and gene expression. Sleep disorders may also arise after, or be aggravated by, an individual’s cancer and cancer treatment. Treating a person with cancer’s sleep disorder may help improve their healing, mental health, cognition, and overall resilience. Methods: Studies examining a variety of aspects of the relationship between sleep and cancer were found by searching the National Library of Medicine and characterized by their specific information provided on the relationship between sleep and cancer. Results: This review article summarizes our current understanding of the complex inter-relationship between sleep and cancer, the underlying mechanisms that create these connections, and the methods and impact of treating sleep issues in cancer patients. The article also outlines an approach to sleep complaints for clinicians caring for patients with cancer. Conclusions: Significant research is still needed to understand the full relationship between sleep disorders and cancer. The impact of sleep issues on cancer and of cancer on sleep appears to be specific to the tissue and the molecular type of cancer. The treatment of sleep disorders is multimodal, and offers a promising avenue to improve the health and quality of life of cancer patients.  \nKeywords: sleep; sleep disorders; sleep disruption; cancer; insomnia; excessive sleepiness  \n1. Introduction  \n1.1. What Is Sleep?  \nSleep is a normal dynamic physiological state, which is characterized by the decreased responsiveness of the central nervous system to the environment. During this state, several brain and body functions occur that are important in the maintenance of organs and maximizing performance. Sleep is regulated, in part, by the accumulation of byproducts  \nfrom neuronal and somatic activity, the homeostatic drive, and by an individu","cbCaiaCrojJo8dkH","https://ap.wps.com/l/cbCaiaCrojJo8dkH","pdf",1351639,26,"English","# Simple Summary\n# Abstract\n# Keywords\n# 1. Introduction\n## 1.1. What Is Sleep?","[{\"question\":\"What is the aim of this review on sleep and cancer?\",\"answer\":\"To summarize current information on sleep issues and their relationship with cancer development and progression, including how cancer can affect sleep and practical treatment options for clinicians.\"},{\"question\":\"How does this review describe mechanisms linking sleep disorders to cancer?\",\"answer\":\"It explains links through altered metabolism, effects on immune response, and changes in hormones and gene expression, with sleep disorders potentially arising after or being worsened by cancer and its treatment.\"},{\"question\":\"What does the review conclude about research and treatment?\",\"answer\":\"It states that significant research is still needed to fully understand the relationship, that effects appear to vary by cancer tissue and molecular type, and that treatment of sleep disorders is multimodal and promising for quality of life.\"}]","Sleep and Cancer - Review | PDF",1790159080,66]