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Solute carrier family 25 member 19 (SLC25A19) contributes to cellular functions, including tumor biology, yet its precise role in CRC regulation remains insufficiently understood. This study aimed to define SLC25A19’s role and mechanism in CRC development. Methods evaluated expression, functional phenotypes, and in vivo tumor growth; mechanisms were probed via phospho-kinase array.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/slc25a19-drives-colorectal-cancer-progression-by-regulating-p53-research-article/331360/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/slc25a19-drives-colorectal-cancer-progression-by-regulating-p53-research-article/331360.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the purpose of investigating SLC25A19 in colorectal cancer?","Question",{"text":112,"@type":113},"To uncover the role and underlying mechanism of SLC25A19 in CRC development and regulation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the study assess SLC25A19 expression and its effects?",{"text":117,"@type":113},"It used GEPIA database analysis and immunohistochemical staining, then evaluated CRC cell phenotypes after knocking down SLC25A19 using multiple in vitro assays and an in vivo xenograft model.",{"name":119,"@type":110,"acceptedAnswer":120},"What mechanism connects SLC25A19 knockdown to changes in CRC behavior?",{"text":121,"@type":113},"SLC25A19 silencing upregulated the p53 pathway, which mediated the observed functional effects on CRC cells and tumor growth.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331360,1790314341,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","DOI: 10. 1002/cam4 .70253  \nRESEAR CH ARTICLE  \nSLC25A19 drives colorectal cancer progression by regulating p53  \nJinbo Jiang1 | Xuemei Li2 | Jiayong Wang1 | Shaofei Chen3 | Lingjuan Chen4,5   \n1Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, China  \n2Advanced Medical Research Institute, School of Medicine, Shandong University, Jinan, Shandong, China 3Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China  \n4Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China  \n5Institute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China  \nCorrespondence  \nLingjuan Chen, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.  \nEmail: [chenlingjuan@hust.edu.cn](chenlingjuan@hust.edu.cn)  \nFunding information  \nNatural Science Foundation of Shandong Province, Grant/Award Number: ZR2019MH071; the Beijing Kechuang Medical Development Foundation Fund of China, Grant/ Award Number: KC2021-JX-0186-31; Bethune-Cancer Radiotherapy Translational Medicine Research Fund of China, Grant/Award Number:  \nflzh202117  \nAbstract  \nBackground: Investigating the molecular mechanism of colorectal cancer (CRC), a common lethal malignancies worldwide, is of great clinical significance. Solute carrier family 25 member 19 (SLC25A19) is a member of the solute carrier family that contribute to cellular functions, including tumor biology. Recently, many studies have attention on uncovering the relationship of SLC25A19 with malignant cancers, but its precise involvement in the regulation of CRC has not been thoroughly understood. This study sought to uncover the role and mechanism ofSLC25A19 in CRC development.  \nMethods: The GEPIA database and immunohistochemical staining were utilized to detect the expression ofSLC25A19 in CRC tissues. The functional influences of SLC25A19 on CRC cell phenotypes were evaluated through a series of assays including celigo cell count, colony formation, CCK-8, flow cytometry, wound healing, and transwell assays following knocking down SLC25A19. Subsequently, thexenograft tumor model was constructed to evaluate the effect of SLC25A19 on tumor growth in vivo. The underlying mechanisms of SLC25A19 silencing were investigated using the human phospho-kinase array.  \nResults: This study demonstrated the upregulation ofSLC25A19 in CRC and its significant correlation with unfavorable prognosis in CRC patients. Suppression ofSLC25A19 resulted in significant inhibition of cell proliferation, colony formation, and cell migration, alongside a boost in cell apoptosis. In vivo experiments revealed that silenced SLC25A19 displayed reduced growth rates and formed smaller xenografts. Mechanistically, the p53 pathway was found to be upregulated by SLC25A19 knockdown and mediated the function ofSLC25A19 . Conclusions: Consequently, SLC25A19 was identified as a novel molecule with key regulatory ability in CRC development.  \nKEYWORDS  \napoptosis, colorectal cancer, p53, proliferation, SLC25A19  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.  \nCancer Medicine. 2024;13:e70253 .  \n[https://doi.org/10.1002/cam4.70253](https://doi.org/10.1002/cam4.70253)  \n[wileyonlinelibrary.com/journal/cam4](wileyonlinelibrary.com/journal/cam4)  \n1 of 14  \n1 | INTRODUCTION  \nColorectal cancer (CRC) is a gastrointestinal tract malignancy that typically exhibits asymptomatic or insignificant symptoms during its early stages. It ranks as the third most prevalent cancer worldwide.1 In 2020, the World Health Organization (WHO) reported al","cbCaiikUj8180Krx","https://ap.wps.com/l/cbCaiikUj8180Krx","pdf",28113876,14,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the purpose of investigating SLC25A19 in colorectal cancer?\",\"answer\":\"To uncover the role and underlying mechanism of SLC25A19 in CRC development and regulation.\"},{\"question\":\"How did the study assess SLC25A19 expression and its effects?\",\"answer\":\"It used GEPIA database analysis and immunohistochemical staining, then evaluated CRC cell phenotypes after knocking down SLC25A19 using multiple in vitro assays and an in vivo xenograft model.\"},{\"question\":\"What mechanism connects SLC25A19 knockdown to changes in CRC behavior?\",\"answer\":\"SLC25A19 silencing upregulated the p53 pathway, which mediated the observed functional effects on CRC cells and tumor growth.\"}]","SLC25A19 drives colorectal cancer progression by regulating p53 - Research Article | PDF",1789992908,35]