[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-384107-105":59,"doc-detail-384107-en":129},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":122,"head_meta":124,"extra_data":126,"updated_unix":128},105,"en","slam-modification-as-an-immune-modulatory-therapeutic-approach-in-cancer","SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer","","The Signaling Lymphocyte Activation Molecule (SLAM) receptor family is presented as a key regulator of immune responses in tumor microenvironments. Comprising nine mostly immune-cell–surface receptors, SLAM members are described as influencing both pro- and anti-tumor immune activities, thereby affecting cancer progression and treatment responses. Because immunotherapy resistance persists, the review highlights SLAM-targeted strategies. It also emphasizes safety, the need for rigorous clinical trials, and the potential of single-cell RNA sequencing and advanced imaging to enable more precise, patient-tailored therapies.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/slam-modification-as-an-immune-modulatory-therapeutic-approach-in-cancer/384107/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/slam-modification-as-an-immune-modulatory-therapeutic-approach-in-cancer/384107.png","ImageObject",300,407,{"name":92,"@type":93},"McQueen","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-24",true,{"@type":101,"interactionType":102,"userInteractionCount":8},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What is the SLAM family, and why is it important in cancer?","Question",{"text":111,"@type":112},"The SLAM family refers to nine SLAM receptors that regulate immune responses on immune cell surfaces. The review explains that SLAM members can either enhance or dampen tumor–immune interactions, influencing progression and treatment outcomes.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"Which cancers and SLAM members are discussed in the review?",{"text":116,"@type":112},"The review highlights SLAM roles across multiple cancer types, including colorectal cancer and melanoma, and discusses specific members such as SLAMF8 and SLAMF9, along with SLAMF1 through SLAMF9 in the family overview.",{"name":118,"@type":109,"acceptedAnswer":119},"How might modern technologies support SLAM-targeted cancer treatments?",{"text":120,"@type":112},"The review points to technologies such as single-cell RNA sequencing and advanced imaging to clarify tumor–immune interactions. This supports the potential development of more precise, SLAM-focused therapeutic approaches.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},384107,1790293338,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":138,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},5909890329169,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","cancers   \nReview  \nSLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer  \nAlireza Tojjari 1, Francis J. Giles 2, Maysa Vilbert 1, Anwaar Saeed 1 and Ludimila Cavalcante 3, *  \nCitation: Tojjari, A.; Giles, F.J.; Vilbert, M.; Saeed, A.; Cavalcante, L. SLAM Modification as an  \nImmune-Modulatory Therapeutic Approach in Cancer. Cancers 2023, 15, 4808. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers15194808  \nAcademic Editor: David Wong  \nReceived: 8 September 2023  \nRevised: 22 September 2023  \nAccepted: 28 September 2023  \nPublished: 29 September 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Medicine, Division of Hematology & Oncology, University of Pittsburgh Medical  \nCenter (UPMC), Pittsburgh, PA 15213, USA; [alirezatojjari@gmail.com](alirezatojjari@gmail.com) (A.T.); [maysavilbert@gmail.com](maysavilbert@gmail.com) (M.V.)  \n2 Developmental Therapeutics LLC, Chicago, IL 60611, USA  \n3 Novant Health Cancer Institute, Charlotte, NC 28204, USA  \n* Correspondence: [ludi.cavalcante@gmail.com](ludi.cavalcante@gmail.com)  \nSimple Summary: In the dynamic realm of cancer research, the Signaling Lymphocyte Activation Molecule (SLAM) family has emerged as a significant factor in modulating immune responses within tumors. This review delves into the roles of specific SLAM members, such as SLAMF8 and SLAMF9, and their impact on tumor progression in cancers like colorectal cancer and melanoma. Recent immunotherapy advances show promise, but challenges like resistance persist. Insights suggest that the SLAM family might be a key to overcoming this resistance. Advances in technology, including single-cell RNA sequencing, help to demystify tumor interactions, and SLAM-focused treatments could potentially revolutionize cancer care. This article underscores the importance of patient safety and calls for thorough research to bring the potential of SLAM in cancer treatment to fruition.  \nAbstract: In the field of oncology, the Signaling Lymphocyte Activation Molecule (SLAM) family is emerging as pivotal in modulating immune responses within tumor environments. The SLAM family comprises nine receptors, mainly found on immune cell surfaces. These receptors play complex roles in the interaction between cancer and the host immune system. Research suggests SLAM's role in both enhancing and dampening tumor-immune responses, influencing the progression and treatment outcomes of various cancers. As immunotherapy advances, resistance remains an issue. The nuanced roles of the SLAM family might provide answers. With the rise in technologies like single-cell RNA sequencing and advanced imaging, there is potential for precise SLAM-targeted treatments. This review stresses patient safety, the importance of thorough clinical trials, and the potential of SLAM-focused therapies to transform cancer care. In summary, SLAM's role in oncology signals a new direction for more tailored and adaptable cancer treatments.  \nKeywords: SLAM; SLAMF; cancer; immune modulation; CLL; AML; MM; HNSCC; HCC; CRC; melanoma  \n1. Introduction  \n1.1. Introduction to the SLAM Family  \nCellular interactions, instrumental in guiding the immune response, chiefly influence the differentiation and proliferation of immune cells. Such interactions encompass a diverse set of cells, leading to what is termed heterotypic engagements [1] . Central to these interactions is the signaling lymphocytic activation molecule (SLAM) receptor family. The SLAM family includes nine transmembrane receptors labeled SLAMF1 through SLAMF9 . Except for SLAMF2 and SLAMF4, which interact reciprocally, these receptors predominantly a","cbCaiuPiMN57c80K","https://ap.wps.com/l/cbCaiuPiMN57c80K","pdf",668212,13,"English","# 1. Introduction\n## 1.1. Introduction to the SLAM Family\n## 1.2. SLAM's Role in Host Defenses and Immune Responses","[{\"question\":\"What is the SLAM family, and why is it important in cancer?\",\"answer\":\"The SLAM family refers to nine SLAM receptors that regulate immune responses on immune cell surfaces. The review explains that SLAM members can either enhance or dampen tumor–immune interactions, influencing progression and treatment outcomes.\"},{\"question\":\"Which cancers and SLAM members are discussed in the review?\",\"answer\":\"The review highlights SLAM roles across multiple cancer types, including colorectal cancer and melanoma, and discusses specific members such as SLAMF8 and SLAMF9, along with SLAMF1 through SLAMF9 in the family overview.\"},{\"question\":\"How might modern technologies support SLAM-targeted cancer treatments?\",\"answer\":\"The review points to technologies such as single-cell RNA sequencing and advanced imaging to clarify tumor–immune interactions. This supports the potential development of more precise, SLAM-focused therapeutic approaches.\"}]","SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer | PDF",1790261255,33]