[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31631":3,"doc-seo-31631":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31631,137441390410,"Hazel","https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984",8,"Research & Report","Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds","Macrophages orchestrate wound healing by driving early inflammation, clearing pathogens, wound debris, and apoptotic cells, then switching to repair support through the suppression of inflammation and secretion of signals that regulate keratinocyte, fibroblast, and endothelial proliferation, differentiation, migration, and neovascularisation. Their behavior is complex, reflecting distinct phenotypes from multiple origins across repair stages. In diabetes, macrophages show hyperresponsiveness to inflammatory stimuli, increased pro-inflammatory cytokines, impaired phagocytosis and efferocytosis, reduced M2 reparative macrophage numbers, delayed closure, infection risk, and a contribution to diabetic foot ulcers and possible amputation. Targeting macrophage dysregulation and associated inflammation enables improved therapies.","cbCaioUYu089ccw0","https://ap.wps.com/l/cbCaioUYu089ccw0","pdf",909612,1,11,"English","en","# Review\n## Clinical and economic need for better wound therapies\n## Skin wound healing and macrophage function\n## Macrophage dysfunction in diabetic wounds","[{\"question\":\"What role do macrophages play during the early and later stages of wound healing?\",\"answer\":\"Early macrophages promote inflammation and remove pathogens, wound debris, and apoptotic cells. Later they dampen inflammation and release factors that support proliferation, differentiation, migration, neovascularisation, and wound closure.\"},{\"question\":\"How does diabetes alter macrophage behavior in wounds?\",\"answer\":\"Diabetic macrophages become hyperresponsive to inflammatory stimuli with higher secretion of pro-inflammatory cytokines. They also show reduced phagocytosis and efferocytosis, which limits pathogen clearance and reduces the M2 reparative macrophage population.\"},{\"question\":\"Why is macrophage dysregulation important for diabetic foot ulcers and treatment outcomes?\",\"answer\":\"Impaired efferocytosis and reduced M2 reparative macrophages can contribute to ulcer formation, delayed healing, and increased infection risk, potentially leading to amputation. Better therapies can be developed by understanding these immune alterations and the associated inflammation.\"}]",1779829273,28,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"skin-wound-healing-normal-macrophage-function-and-macrophage-dysfunction-in-diabetic-wounds","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/skin-wound-healing-normal-macrophage-function-and-macrophage-dysfunction-in-diabetic-wounds/31631/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-26",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What role do macrophages play during the early and later stages of wound healing?","Question",{"text":73,"@type":74},"Early macrophages promote inflammation and remove pathogens, wound debris, and apoptotic cells. Later they dampen inflammation and release factors that support proliferation, differentiation, migration, neovascularisation, and wound closure.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How does diabetes alter macrophage behavior in wounds?",{"text":78,"@type":74},"Diabetic macrophages become hyperresponsive to inflammatory stimuli with higher secretion of pro-inflammatory cytokines. They also show reduced phagocytosis and efferocytosis, which limits pathogen clearance and reduces the M2 reparative macrophage population.",{"name":80,"@type":71,"acceptedAnswer":81},"Why is macrophage dysregulation important for diabetic foot ulcers and treatment outcomes?",{"text":82,"@type":74},"Impaired efferocytosis and reduced M2 reparative macrophages can contribute to ulcer formation, delayed healing, and increased infection risk, potentially leading to amputation. Better therapies can be developed by understanding these immune alterations and the associated inflammation.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]