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Following wound damage, hemostasis, inflammation, new tissue formation, and tissue remodeling are driven by resident and recruited immune cells that clear pathogens and debris while directing regeneration. When this repair program fails, persistent inflammation can contribute to chronic non-healing wounds and increase skin tumorigenesis. Tumors can also hijack wound-healing pathways to support survival and growth, so immune regulation is central to both repair and cancer development.",{"@graph":69,"@context":114},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/skin-immunity-in-wound-healing-and-cancer/380141/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/skin-immunity-in-wound-healing-and-cancer/380141.png","ImageObject",300,407,{"name":92,"@type":93},"Rhys","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108],{"name":109,"@type":110,"acceptedAnswer":111},"Why is immune regulation relevant to both wound healing and skin cancer?","Question",{"text":112,"@type":113},"Tumors can co-opt the wound-healing response to enhance their survival and growth, so controlling inflammation and immune cell functions affects both outcomes.","Answer","https://schema.org",{"og:url":83,"og:type":116,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":118,"canonical":83},"index,follow",{"doc_id":120,"site_id":62},380141,1790568946,{"code":4,"msg":5,"data":123},{"doc_id":120,"user_id":124,"nickname":92,"user_avatar":125,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":131,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":132,"faqs":133,"seo_title":134,"seo_description":67,"update_tm":135,"read_time":136},687207024643,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","TYPE Review  \nPUBLISHED 16 June 2023  \nDOI 10.3389/fimmu.2023.1060258  \nOPEN ACCESS  \nEDITED BY  \nSnehlata Kumari,  \nThe University of Queensland, Australia  \nREVIEWED BY  \nSebastian Willenborg,  \nUniversity Hospital of Cologne, Germany Holly Anderton,  \nThe University of Melbourne, Australia  \n*CORRESPONDENCE Tatyana Chtanova  \n [t.chtanova@unsw.edu.au](t.chtanova@unsw.edu.au)  \nRECEIVED 03 October 2022  \nACCEPTED 24 May 2023  \nPUBLISHED 16 June 2023  \nCITATION  \nJakovija A and Chtanova T (2023) Skin immunity in wound healing and cancer. Front. Immunol. 14:1060258 .  \ndoi: 10.3389/fimmu.2023.1060258  \nCOPYRIGHT  \n© 2023 Jakovija and Chtanova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nSkin immunity in wound healing and cancer  \nArnolda Jakovija 1,2 and Tatyana Chtanova 1,3*  \n1 Immunity Theme, Garvan Institute of Medical Research, Sydney, Australia, 2St. Vincent’s School of Medicine, Faculty of Medicine, University of New South Wales, Sydney, Australia, 3School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, Australia  \nThe skin is the body’s largest organ. It serves as a barrier to pathogen entry and the first site of immune defense. In the event of a skin injury, a cascade of events including inflammation, new tissue formation and tissue remodeling contributes to wound repair. Skin-resident and recruited immune cells work together with non-immune cells to clear invading pathogens and debris, and guide theregeneration of damaged host tissues. Disruption to the wound repair process can lead to chronic inflammation and non-healing wounds. This, in turn, can promote skin tumorigenesis. Tumors appropriate the wound healing response asa way of enhancing their survival and growth. Here we review the role of resident and skin-infiltrating immune cells in wound repair and discuss their functions in regulating both inflammation and development of skin cancers.  \nKEYWORDS  \nskin wound healing, skin immunity, innate response, skin cancer immunity, skin adaptive immunity  \n1 Overview  \nThe skin is not only a physical barrier protecting us from infection but also an important immunological site, which in humans contains an estimated 20 billion T cells as well as a range of cells with innate and innate-like roles. Among them are Langerhans cells, dermal dendritic cells (DCs), macrophages, neutrophils, mast cells and innate lymphoid cells. These immune cells, together with keratinocytes and neurons, interact with the skin microbiota, to maintain skin homeostasis while protecting against pathogen invasion. Several recent reviews (1–3) explain how immune subsets and specialized immunological sites (such as hair follicles and sweat glands) interact with the skin microbiome. This review will focus specifically on how skin immune cells mediate wound repair and how this process can be co-opted by tumors.  \n2 Cutaneous tissue injury and wound  \nrepair cascade  \nWound healing is a natural physiological reaction to tissue injury designed to prevent the onset of infection and restore tissue integrity (4) . It follows a finely coordinated  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \nmultistep process that includes hemostasis, inflammation, proliferation (new tissue formation), and tissue remodeling (5) (Figure 1) .  \n2.1 One to three days after injury  \n2.1.1 Hemostasis and humoral inflammation  \nVascular damage with resultant local hemorrhage is a universal characteristic of tissue injury (6) . A few minutes after injury, platelets in the circulation begin to stick to the injured si","cbCaikJ9uXkhysm3","https://ap.wps.com/l/cbCaikJ9uXkhysm3","pdf",17386373,"English","# Overview\n# Cutaneous tissue injury and wound repair cascade\n## One to three days after injury\n### Hemostasis and humoral inflammation\n### Cellular inflammation\n## One to ten days after injury\n### New tissue formation","[{\"question\":\"Why is immune regulation relevant to both wound healing and skin cancer?\",\"answer\":\"Tumors can co-opt the wound-healing response to enhance their survival and growth, so controlling inflammation and immune cell functions affects both outcomes.\"}]","Skin immunity in wound healing and cancer | PDF",1790238935,25]