[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-378250-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-378250-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","skin-cancer-microenvironment-what-we-can-learn-from-skin-aging","Skin Cancer Microenvironment: What We Can Learn from Skin Aging?","","Aging in skin involves loss of fibrous tissue, reduced cell turnover, and declining immune competence, while environmental exposure—especially ultraviolet—adds extrinsic photoaging damage. Although photoaging is not usually viewed as a direct pathogenic event, it alters cutaneous biology and elevates skin carcinogenesis risk. Cellular aging features senescent cells with impaired proliferation and hyper-secretory signaling, which can both suppress damaged-cell expansion and, through chronic accumulation and inadequate clearance, increase cancer incidence. Tumor cells may also reprogram resident fibroblasts toward pro-tumor, senescence-like phenotypes. This review summarizes aging-related changes that may prime neoplasms or increase melanoma and non-melanoma cancer aggressiveness.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/skin-cancer-microenvironment-what-we-can-learn-from-skin-aging/378250/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/skin-cancer-microenvironment-what-we-can-learn-from-skin-aging/378250.png","ImageObject",300,407,{"name":42,"@type":43},"Adam","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-04","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",19,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How does skin aging and photoaging relate to skin cancer risk?","Question",{"text":63,"@type":64},"Skin aging reduces cell turnover and immune competence, while photoaging from ultraviolet exposure changes cutaneous biology and increases the risk of skin carcinogenesis.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What cellular features define aging in the skin relevant to cancer biology?",{"text":68,"@type":64},"Aging is characterized by senescent cells with reduced or absent proliferative capacity and aberrant hyper-secretory activity.",{"name":70,"@type":61,"acceptedAnswer":71},"Why can senescence be both protective and harmful in cancer?",{"text":72,"@type":64},"Senescence can prevent uncontrolled proliferation of damaged cells and promote clearance via paracrine secretion, but cumulative insults and poor clearance in the elderly can increase cancer incidence.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},378250,1790269546,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":113,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nSkin Cancer Microenvironment: What We Can Learn from Skin Aging?  \nAndrea D'Arino 1, Silvia Caputo 2, Laura Eibenschutz 1, Paolo Piemonte 1, Pierluigi Buccini 1, Pasquale Frascione 1 and Barbara Bellei 2, *  \nCitation: D'Arino, A.; Caputo, S.; Eibenschutz, L.; Piemonte, P.; Buccini, P.; Frascione, P.; Bellei, B. Skin Cancer Microenvironment: What We Can Learn from Skin Aging? Int. J. Mol. Sci. 2023, 24, 14043. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms241814043](10.3390/ijms241814043)  \nAcademic Editor: Walter Wahli  \nReceived: 4 August 2023  \nRevised: 30 August 2023  \nAccepted: 9 September 2023  \nPublished: 13 September 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Oncologic and Preventative Dermatology, San Gallicano Dermatological Institute, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 00141 Rome, Italy  \n2 Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 00141 Rome, Italy  \n* [Correspondence: barbara.bellei@ifo.it](Correspondence: barbara.bellei@ifo.it); Tel.: +39-0652666246; Fax: +39-0652666247  \nAbstract: Aging is a natural intrinsic process associated with the loss of fibrous tissue, a slower cell turnover, and a reduction in immune system competence. In the skin, the continuous exposition of environmental factors superimposes extrinsic damage, mainly due to ultraviolet radiation causing photoaging. Although not usually considered a pathogenic event, photoaging affects cutaneous biology, increasing the risk of skin carcinogenesis. At the cellular level, aging is typified by the rise of senescence cells a condition characterized by reduced or absent capacity to proliferate and aberrant hyper-secretory activity. Senescence has a double-edged sword in cancer biology given that senescence prevents the uncontrolled proliferation of damaged cells and favors their clearance by paracrine secretion. Nevertheless, the cumulative insults and the poor clearance of injured cells in the elderly increase cancer incidence. However, there are not conclusive data proving that aged skin represents a permissive milieu for tumor onset. On the other hand, tumor cells are capable of activating resident fibroblasts onto a pro-tumorigenic phenotype resembling those of senescent fibroblasts suggesting that aged fibroblasts might facilitate cancer progression. This review discusses changes that occur during aging that can prime neoplasm or increase the aggressiveness of melanoma and non-melanoma skin cancer.  \nKeywords: BCC; skin; SCC; melanoma; skin aging; CAFs  \n1. Introduction  \nSkin cancer is one of the most common types of cancer worldwide, with an estimated 3.3 million cases diagnosed each year [1] . Overall, melanoma incidence is ongoing a dramatic rise, rapidly becoming the fifth leading cancer in males and females in the United States [2,3] . At the same time, non-melanoma skin cancer, which comprises basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the first and second most common types of skin cancer, respectively [4] . Moreover, these data probably represent an underestimation considering that both BCC and SCC are not typically reported in cancer registries. BCC and SCC, once defined as “epitheliomas” due to their low metastatic potential and most frequently grouped as non-melanoma skin cancers (NMSCs), both originate from epidermal keratinocytes [5] . Conversely, melanoma is a malignant proliferation of pigmentproducing cells known as melanocytes. The microenvironment in which skin cancer arisesand progresses is complex and ","cbCaiuUZ3OspiL0v","https://ap.wps.com/l/cbCaiuUZ3OspiL0v","pdf",1530222,"English","# Introduction\n## Skin cancer epidemiology\n## Role of the tumor microenvironment\n## Cancer-associated fibroblasts (CAFs) and aging-related stromal changes","[{\"question\":\"How does skin aging and photoaging relate to skin cancer risk?\",\"answer\":\"Skin aging reduces cell turnover and immune competence, while photoaging from ultraviolet exposure changes cutaneous biology and increases the risk of skin carcinogenesis.\"},{\"question\":\"What cellular features define aging in the skin relevant to cancer biology?\",\"answer\":\"Aging is characterized by senescent cells with reduced or absent proliferative capacity and aberrant hyper-secretory activity.\"},{\"question\":\"Why can senescence be both protective and harmful in cancer?\",\"answer\":\"Senescence can prevent uncontrolled proliferation of damaged cells and promote clearance via paracrine secretion, but cumulative insults and poor clearance in the elderly can increase cancer incidence.\"}]","Skin Cancer Microenvironment: What We Can Learn from Skin Aging? | PDF",1790229165,76]