[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-377844-105":59,"doc-detail-377844-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","skin-cancer-correlations-in-psoriatic-patients-review","Skin Cancer Correlations in Psoriatic Patients - Review","","Psoriasis is a common chronic, immune-mediated inflammatory disease linked to multiple comorbidities, including psoriatic arthritis, cardiovascular disease, metabolic syndrome, inflammatory digestive syndromes, and depression. Less studied is its association with cancers at specific sites. The review explains how immune mechanisms and inflammation can drive neoplastic development, highlighting myeloid dendritic cells and infection-induced chronic inflammation. The aim is to synthesize available data to help patients and care providers prevent skin cancer in psoriatic patients.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/skin-cancer-correlations-in-psoriatic-patients-review/377844/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/skin-cancer-correlations-in-psoriatic-patients-review/377844.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What comorbidities are commonly associated with psoriasis?","Question",{"text":113,"@type":114},"Psoriasis is commonly linked to psoriatic arthritis, cardiovascular disease, metabolic syndrome, inflammatory digestive syndromes, and depression.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why might psoriasis increase the risk of cancer, particularly skin cancer?",{"text":118,"@type":114},"The article describes chronic systemic inflammation and immune mechanisms that can support neoplastic development, including the role of inflammation in creating local persistent inflammatory environments and contributing to DNA damage.",{"name":120,"@type":111,"acceptedAnswer":121},"What is the purpose of the review?",{"text":122,"@type":114},"The review aims to summarize available data on the connection between psoriasis and skin cancer risk, supporting proper management of psoriatic patients to help prevent skin cancer development.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},377844,1790379663,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","cancers   \nReview  \nSkin Cancer Correlations in Psoriatic Patients  \nDaniel Octavian Costache 1, Horia Bejan 2,*, Marcela Poenaru 3 and Raluca Simona Costache 4, *  \nCitation: Costache, D.O.; Bejan, H.; Poenaru, M.; Costache, R.S. Skin Cancer Correlations in Psoriatic Patients. Cancers 2023, 15, 2451 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers15092451  \nAcademic Editor: 􀂁ngele Juarranz  \nReceived: 26 March 2023  \nRevised: 20 April 2023  \nAccepted: 24 April 2023  \nPublished: 25 April 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 II Dermatology Discipline, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania; [daniel.costache@umfcd.ro](daniel.costache@umfcd.ro)  \n2 Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania  \n3 Dermatology Department, Carol Davila University Central Emergency Military Hospital,  \n010825 Bucharest, Romania; [marcelapoenaru@yahoo.com](marcelapoenaru@yahoo.com)  \n4 Internal Medicine and Gastroenterology Discipline, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania  \n* [Correspondence: bejanhoria@yahoo.com](Correspondence: bejanhoria@yahoo.com) (H.B.); [raluca.costache@umfcd.ro](raluca.costache@umfcd.ro) (R.S.C.)  \nSimple Summary: Psoriasis is an inflammatory disease associated with important comorbidities that shape a specific clinical frame. Concerns have been expressed in recent decades about the role of systemic inflammation in the promotion of various organ neoplasia. Moreover, psoriasis treatment is chronic, usually lifelong, and uses various classes of drugs, of which some have an intrinsic effect on the body's cancer-control mechanisms. While in other works we studied the correlation between psoriasis, its treatment, and organ cancers, this paper is a review of available data that evaluate the connection and intricate risk of skin cancer in psoriatic patients. Good knowledge of these risks might help both the patient and the care provider to avoid the development of skin neoplasia in selected patients.  \nAbstract: Psoriasis is a common chronic, immune-mediated, inflammatory disease with associated comorbidities. Common psoriasis-associated comorbidities include psoriatic arthritis, cardiovascular disease, metabolic syndrome, inflammatory digestive syndromes, and depression. A less studied association is between psoriasis and specific-site cancers. A key cell in the pathophysiology of psoriasis is the myeloid dendritic cell, which links the innate and adaptive immune systems, and therefore is involved in the control of cancer-prevention mechanisms. The relationship between cancer and inflammation is not new, with inflammation being recognized as a key element in the development of neoplastic foci. Infection leads to the development of local chronic inflammation, which further leads to the accumulation of inflammatory cells. Various phagocytes produce reactive oxygen species that cause mutations in cellular DNA and lead to the perpetuation of cells with altered genomes. Therefore, in inflammatory sites, there will be a multiplication of cells with damaged DNA, leading to tumor cells. Over the years, scientists have tried to assess the extent to which psoriasis can increase the risk of developing skin cancer. Our aim is to review the available data and present some information that might help both the patients and the care providers in properly managing psoriatic patients to prevent skin cancer development.  \nKeywords: psoriasis; skin cancer; treatment  \n1. Introduction  \nPsoriasis is a common chronic, immune-mediate","cbCaioDVKewJtcJb","https://ap.wps.com/l/cbCaioDVKewJtcJb","pdf",319146,13,"English","# Introduction\n## Psoriasis as a systemic inflammatory disease\n## Psoriasis comorbidities and quality of life\n## Risk of specific-site cancers in psoriasis\n# Review scope and background","[{\"question\":\"What comorbidities are commonly associated with psoriasis?\",\"answer\":\"Psoriasis is commonly linked to psoriatic arthritis, cardiovascular disease, metabolic syndrome, inflammatory digestive syndromes, and depression.\"},{\"question\":\"Why might psoriasis increase the risk of cancer, particularly skin cancer?\",\"answer\":\"The article describes chronic systemic inflammation and immune mechanisms that can support neoplastic development, including the role of inflammation in creating local persistent inflammatory environments and contributing to DNA damage.\"},{\"question\":\"What is the purpose of the review?\",\"answer\":\"The review aims to summarize available data on the connection between psoriasis and skin cancer risk, supporting proper management of psoriatic patients to help prevent skin cancer development.\"}]","Skin Cancer Correlations in Psoriatic Patients - Review | PDF",1790227353,33]