[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-461432-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-461432-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","single-center-real-world-experience-with-the-varipulse-platform-for-pulsed-field-ablation-of-atrial-fibrillation-atrial-flutter-and-redo-procedures","Single-Center Real World Experience with the VARIPULSE Platform for Pulsed Field Ablation of Atrial Fibrillation, Atrial Flutter, and Redo Procedures","","Pulsed field ablation (PFA) is increasingly applied to pulmonary vein isolation for atrial fibrillation, and this study documents real-world single-center experience using the VARIPULSE™ platform for both pulmonary vein and non-pulmonary vein targets. The retrospective cohort included patients with paroxysmal or persistent AF undergoing VARIPULSE-guided ablation, with PVI performed per protocol and atrial flutters mapped and ablated. Non-PV procedures were common, while acute outcomes and complications were systematically analyzed, concluding feasibility and safety for atypical flutter and non-PV targets.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/single-center-real-world-experience-with-the-varipulse-platform-for-pulsed-field-ablation-of-atrial-fibrillation-atrial-flutter-and-redo-procedures/461432/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/single-center-real-world-experience-with-the-varipulse-platform-for-pulsed-field-ablation-of-atrial-fibrillation-atrial-flutter-and-redo-procedures/461432.png","ImageObject",300,407,{"name":42,"@type":43},"Guten tag","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main purpose of using the VARIPULSE platform in this study?","Question",{"text":63,"@type":64},"To summarize single-center experience with VARIPULSE-guided pulsed field ablation for pulmonary vein isolation and for non-pulmonary vein targets in patients with atrial fibrillation and complex atrial arrhythmias.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which patient groups were included in the retrospective analysis?",{"text":68,"@type":64},"Patients with paroxysmal or persistent atrial fibrillation who underwent catheter ablation using the VARIPULSE catheter were retrospectively included, with PVI performed in all patients.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the study report about feasibility, safety, and atrial flutter termination?",{"text":72,"@type":64},"Ablation of atypical atrial flutter and non-pulmonary vein targets was feasible and safe using the VARIPULSE platform. In mapped and ablated atrial flutters, termination occurred in all but one patient, and major complications were not detected.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},461432,1790956558,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":113,"preview_page_count":4},687212321768,"https://ap-avatar.wpscdn.com/avatar/a0010bdbe886d2fe77?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789897067658708522","Article  \nSingle-Center Real World Experience with the VARIPULSE Platform for Pulsed Field Ablation of Atrial Fibrillation, Atrial Flutter, and Redo Procedures  \nNizar Andria 1,2, Ziad Abuiznait 1, Mussa Saad 1, Samer Yousef 1, Sergey Keselman 1 and Ibrahim Marai 1,2, *  \nAcademic Editor: Boyoung Joung  \nReceived: 19 November 2025  \nRevised: 13 December 2025  \nAccepted: 17 December 2025  \nPublished: 20 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 The Lydia and Carol Kittner, Lea and Benjamin Davidai Division of Cardiovascular Medicine and Surgery, Cardiovascular Department, Tzafon Medical Center, Poriya P.O. Box 15208, Israel;  \n[nizar.andria@gmail.com](nizar.andria@gmail.com) (N.A.)  \n2 The Azrieli Faculty of Medicine, Bar Ilan University, Safed P.O. Box 1589, Israel  \n* Correspondence: [ibrahimmarai1973@gmail.com](ibrahimmarai1973@gmail.com)  \nAbstract  \nBackground/Objectives: Pulsed field ablation (PFA) is increasingly used for pulmonary vein isolation (PVI). One of the emerging single-shot PFA catheters is the variable-loop circular catheter (VARIPULSE™, Biosense Webster, Inc.) which is fully integrated into a three-dimensional mapping system. However, the evidence for the feasibility of ablation of non-pulmonary vein targets is still limited using the VARIPULSE catheter. In this study, we summarize our experience in PVI and mapping/ablation of non-pulmonary vein sites in patients with atrial fibrillation (AF) and complex atrial substrate and arrhythmias using the VARIPULSE catheter. Methods: All patients with paroxysmal or persistent AF who underwent catheter ablation using the VARIPULSE catheter were retrospectively included. PVI was performed in all patients. Spontaneous or inducible atrial flutters were mapped and ablated. Empiric lines were performed at the operator’s discretion. Acute outcomesand complications were analyzed. Results: the study included 60 patients; 25 (41.6%) were females and mean age was 67.15 ± 9.01 years. Thirty four (60%) had persistent AF and six (10%) patients had atrial flutter as the initial rhythm during the index procedure. All patients had PVI using the PFA as per protocol. Most of the patients (76.7%) had non-pulmonary vein ablation sites; posterior wall isolation was performed in 25 (41.7%) patients, roof line in 9 (15%) patients, anterior line in 16 (26.7%) patients, cavotricupsid isthmus in 11 (18.3%) patients and superior vena cava isolation in two (3.3%) patients. Overall, 27 patients had atrial flutters during the index procedure that were mapped andablated using the VARIPULSE catheter. All had termination of atrial flutter except for one patient. Major complications were not detected. Conclusions: Mapping and ablation of atypical atrial flutter and non-pulmonary vein targets are feasible and safe using the VARIPULSE platform.  \nKeywords: pulsed field ablation; VARIPULSE; atrial fibrillation; atrial flutter  \n1. Introduction  \nAtrial fibrillation (AF) stands as the most widespread cardiac arrhythmia, contributing substantially to global health and economic burdens [1] . This condition not only affects patient morbidity and mortality but also significantly increases healthcare costs and resource utilization [1] . Given its prevalence and associated risks, effective treatment modalities are  \ncrucial for improving patient outcomes and alleviating the societal impact of AF [2] . Historically, thermal ablation techniques, such as radiofrequency (RF) and cryoablation, have been the mainstay for rhythm control in AF, yet they carry inherent risks of collateral tissue damage [3] . Pulsed field ablation (PFA) has emerged as a novel alternative, leveraging electroporation to selectively ablate myocardial tissue while minimizing thermal injury to surrounding structures [4] . This method employs ultrarapid electrical ","cbCaivn6QAUszFK1","https://ap.wps.com/l/cbCaivn6QAUszFK1","pdf",2608185,12,"English","# Abstract\n# Introduction","[{\"question\":\"What is the main purpose of using the VARIPULSE platform in this study?\",\"answer\":\"To summarize single-center experience with VARIPULSE-guided pulsed field ablation for pulmonary vein isolation and for non-pulmonary vein targets in patients with atrial fibrillation and complex atrial arrhythmias.\"},{\"question\":\"Which patient groups were included in the retrospective analysis?\",\"answer\":\"Patients with paroxysmal or persistent atrial fibrillation who underwent catheter ablation using the VARIPULSE catheter were retrospectively included, with PVI performed in all patients.\"},{\"question\":\"What did the study report about feasibility, safety, and atrial flutter termination?\",\"answer\":\"Ablation of atypical atrial flutter and non-pulmonary vein targets was feasible and safe using the VARIPULSE platform. In mapped and ablated atrial flutters, termination occurred in all but one patient, and major complications were not detected.\"}]","Single-Center Real World Experience with the VARIPULSE Platform for Pulsed Field Ablation of Atrial Fibrillation, Atrial Flutter, and Redo Procedures | PDF",1790761603]