[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-370742-105":59,"doc-detail-370742-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","simulation-approach-for-common-female-cancers-a-brief-review","Simulation approach for common female cancers - a brief review","","A concise mini-review introduces widely used computer-and-mathematical simulation approaches in cancer research and clinical decision support, focusing on common female malignancies. It explains how simulation modeling uses computational frameworks to test hypothetical scenarios, predict outcomes, and explore interactions among molecular pathways, cell proliferation, and tissue microenvironments. The review surveys applications across breast, cervical, ovarian, and endometrial cancers, highlighting methods such as Monte Carlo, agent-based modeling, and multiscale strategies to support ethical, rapid, and cost-effective hypothesis evaluation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/simulation-approach-for-common-female-cancers-a-brief-review/370742/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/simulation-approach-for-common-female-cancers-a-brief-review/370742.png","ImageObject",300,407,{"name":92,"@type":93},"Adam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the purpose of using simulation approaches in common female cancers?","Question",{"text":112,"@type":113},"Simulation approaches help evaluate hypotheses and predict cancer prevention, diagnosis, and treatment outcomes through rapid, ethical, and cost-effective modeling. They also support investigation of complex biological interactions relevant to disease progression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which simulation methods are commonly used in cancer modeling according to the review?",{"text":117,"@type":113},"The review highlights Monte Carlo simulation, multi-scale modeling, agent-based modeling, and other computational biology methods as commonly used approaches for cancer simulation modeling.",{"name":119,"@type":110,"acceptedAnswer":120},"What cancer types does the review focus on?",{"text":121,"@type":113},"The review focuses on common female cancers, specifically breast, cervical, ovarian, and endometrial cancers, summarizing simulation applications for each.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},370742,1791313718,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","TYPE Mini Review  \nPUBLISHED 09 July 2025  \nDOI 10.3389/fonc.2025.1479225  \nOPEN ACCESS  \nEDITED BY  \nJun-Jun Yeh,  \nDitmanson Medical Foundation Chia-Yi Christian Hospital, Taiwan  \nREVIEWED BY  \nQiongle Peng,  \nAffiliated Hospital of Jiangsu University, China  \n*CORRESPONDENCE  \nZhen-Yu Huang  \n [huangzy@hrbeu.edu.cn](huangzy@hrbeu.edu.cn)  \nRECEIVED 06 September 2024  \nACCEPTED 19 June 2025  \nPUBLISHED 09 July 2025  \nCITATION  \nShen Y, Li C, Tang M-Y and Huang Z-Y (2025) Simulation approach for common female cancers: a brief review.  \nFront. Oncol. 15:1479225 .  \ndoi: 10.3389/fonc.2025.1479225  \nCOPYRIGHT  \n© 2025 Shen, Li, Tang and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nSimulation approach for common female cancers:  \na brief review  \nYing Shen 1,2, Chan Li 1, Mao-Yan Tang 1 and Zhen-Yu Huang 3*  \n1 Department of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine,  \nHarbin, China, 2 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China, 3School of Humanities and Social Sciences, Harbin Engineering University, Harbin, China  \nSimulation approach involves the use of computers and mathematical models to simulate real systems for experimentation or tests that evaluate the behavior and performance of a system or predict the results of various hypothetical scenarios. Due to its rapid development in the context of cancer, we introduce commonly used cancer simulation approach, and review the application of these approach in common cancers of women, such as breast, cervical, ovarian and endometrial cancers, to provide new ideas and directions for cancer study as well as clinical treatment.  \nKEYWORDS  \nsimulation approach, common female cancers, Monte Carlo method, agent-based modeling, computational biology  \n1 Introduction  \nCancer, characterized by the abnormal proliferation of cells in an uncontrolled manner, is a leading cause of death worldwide. According to the WHO, approximately 19.3 million cancer cases were diagnosed in 2020, accounting for one in six deaths, and the number of cases is expected to rise to 28.4 million by 2040 (1) .  \nThe traditional methods of cancer research are mainly clinical trials, in vitro experiments and in vivo experiments, which are important but also have their own shortcomings. For example, clinical trials are not only a lengthy process, but also involve the influence of trial design, patient selection and follow-up, and complex data analysis (2) . In vitro experiments are studied by extracting cells from patients, but cannot fully simulate the physiological environment in vivo, etc. (3); the main advantage of in vivo experiments is the use of replacement animals, but they may be affected by individual differences, environmental factors, time, and ethical issues, etc. (4) .  \nCompared to traditional research methods, cancer simulation is a valuable research direction that can provide an ethical, rapid, and cost-effective approach to various hypotheses and predictions for cancer prevention, diagnosis, and treatment (5) . Simulation modeling involves the use of computer and mathematical models to simulate  \nFrontiers in Oncology 01 [frontiersin.org](frontiersin.org)  \nreal systems for experiments or tests that evaluate the behavior and performance of a system or predict the outcomes of various hypothetical scenarios (6) .  \nCancer simulation is capable of investigating the complex interactions of multiple factors such as molecular pathways, cell proliferation, and tissue microenvironment (2","cbCaitnCb06DhtFf","https://ap.wps.com/l/cbCaitnCb06DhtFf","pdf",1418394,"English","# Introduction\n# Main methods of cancer simulation modeling\n## Simulation modeling based on Monte Carlo method","[{\"question\":\"What is the purpose of using simulation approaches in common female cancers?\",\"answer\":\"Simulation approaches help evaluate hypotheses and predict cancer prevention, diagnosis, and treatment outcomes through rapid, ethical, and cost-effective modeling. They also support investigation of complex biological interactions relevant to disease progression.\"},{\"question\":\"Which simulation methods are commonly used in cancer modeling according to the review?\",\"answer\":\"The review highlights Monte Carlo simulation, multi-scale modeling, agent-based modeling, and other computational biology methods as commonly used approaches for cancer simulation modeling.\"},{\"question\":\"What cancer types does the review focus on?\",\"answer\":\"The review focuses on common female cancers, specifically breast, cervical, ovarian, and endometrial cancers, summarizing simulation applications for each.\"}]","Simulation approach for common female cancers - a brief review | PDF",1790190152,23]