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This article presents a patient case and reviews related studies to improve diagnostic accuracy and reduce misdiagnosis risk. Patient concerns: Symptoms gradually emerged alongside increasing follow-up experiences in breast silicone implantation. Clinicians and pathologists should focus on careful diagnosis. Diagnoses and interventions: Pathology confirmed silicone lymphadenopathy using hematoxylin-eosin staining and immunohistochemistry after lymph node biopsy, with no special treatment at that time. Outcomes: One year later, the patient remained free of discomfort.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/silicone-lymphadenopathy-a-case-report-and-literature-review/455074/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/silicone-lymphadenopathy-a-case-report-and-literature-review/455074.png","ImageObject",300,407,{"name":92,"@type":93},"Bulrr","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is silicone lymphadenopathy difficult to diagnose?","Question",{"text":112,"@type":113},"It is a rare complication of breast silicone implantation, and imaging alone may not be sufficient. Pathological examination under microscopy is often required to confirm the diagnosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the diagnosis confirmed in the reported case?",{"text":117,"@type":113},"The patient’s lymph node tissue was biopsied, and pathology confirmed silicone lymphadenopathy using hematoxylin-eosin staining and immunohistochemistry.",{"name":119,"@type":110,"acceptedAnswer":120},"Was any specific treatment given, and what happened afterward?",{"text":121,"@type":113},"No special treatment was provided at the time of diagnosis. After one year of follow-up, the patient showed no signs of discomfort.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},455074,1790742060,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":39,"preview_page_count":4},5909892115043,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","®  \n Clinical Case Report   \nSilicone lymphadenopathy A case report and literature review  \nXinyue Zhang, MMEDa , Siyi Luo, MMEDb , Qing Xiong, BSNb , Zhichun Wang, MMEDb ,*  \n\n| Abstract\u003Cbr>Rationale: Silicone Lymphadenopathy is a rare complication of breast silicone implantation. Our article reports a case of Silicone Lymphadenopathy and discusses related studies to enhance the accuracy of patient diagnosis and prevent misdiagnosis. Patient concerns: It has gradually occurred with the increase in follow-up cases of breast silicone implantation. Clinicians and pathologists should pay attention to the diagnosis of Silicone Lymphadenopathy.\u003Cbr>Diagnoses: The patient was diagnosed with Silicone Lymphadenopathy by hematoxylin-eosin staining and immunohistochemistry in pathology.\u003Cbr>Interventions: A biopsy tissue was performed on the patient’s lymph nodes. After pathological diagnosis, silicone lymphadenopathy was confirmed. No special treatment was given at that time.\u003Cbr>Outcomes: One year later, the patient showed no signs of discomfort.\u003Cbr>Lessons: As the number of breast augmentation patients increases, although silicone lymphadenopathy is a rare complication of breast augmentation, this condition is becoming more and more common. When diagnosing this disease, we need to thoroughly understand the patient’s medical history, including whether they have a history of breast augmentation or breast cancer, and pay attention to the differential diagnosis. Currently, there is no specific treatment method for this disease.\u003Cbr>Abbreviation: US = ultrasonography. |\n| --- |\n| Keywords: breast, case report, implantation of silicone gel prosthesis, silicone lymphadenopathy |\n\n1. Introduction  \nAt present, silicone is the most common material for breast filling, and its implantation in the body is closely related to the pathogenesis and development of silicone-induced lymph nodes. [1] In the diagnosis of silicone-induced lymph nodes, computerized tomography and ultrasonography (US) can provide some diagnostic evidence, but in most cases, diagnosis under a pathological microscope is required.  \n2. Case presentation  \nA 42-year-old female patient visited our hospital’s breast surgery department 3 years ago. She reported that she could feel multiple nodules in the right axilla, accompanied by tenderness. Our doctors recommended a US examination, which revealed abnormal echoes in the right supraclavicular fossa and subcutaneous tissue of the right axilla, suggesting  \nWritten informed consent was obtained from the patient for publication of this case report and accompanying images.  \nThe authors have no funding and conflicts of interest to disclose.  \nAll data generated or analyzed during this study are included in this published article [and its supplementary information files].  \nEthical approval was not required because this study was an observational study and all details have been de-identified to ensure that the patient’s identity cannot be ascertained in any way. The patient provided informed consent for the puncture operation. Our study merely observed and recorded the natural behaviors and physiological indicators of the patients, and would not have any impact on the health and rights of the patients.  \na Department of Pathology, Jiujiang NO. 1 People’s Hospital, Jiujiang, People’s Republic of China, b Department of Breast, Jiujiang NO. 1 People’s Hospital, Jiujiang, People’s Republic of China.  \nextrusion of breast implants. After inquiring about the medical history, it was discovered that the patient had undergone bilateral breast implant surgery 10 years ago. At that time, our hospital did not provide any treatment measures for the patient. Last year, the patient returned for a follow-up medical examination, stating that she had removed the implants 1 year ago. Breast ultrasound showed several slightly hyperechoic masses in the right axilla, measuring ~28 mm × 17 mm, 30 mm × 19 mm, and 19.3 mm × 14.7 mm (Fig. 1). The boundaries were ","cbCaivaqs6KWY5KG","https://ap.wps.com/l/cbCaivaqs6KWY5KG","pdf",524090,"English","# Introduction\n## Diagnosis approaches\n# Case presentation\n## Imaging findings and clinical history\n# Pathology and outcomes\n## Histology confirmation and follow-up","[{\"question\":\"Why is silicone lymphadenopathy difficult to diagnose?\",\"answer\":\"It is a rare complication of breast silicone implantation, and imaging alone may not be sufficient. Pathological examination under microscopy is often required to confirm the diagnosis.\"},{\"question\":\"How was the diagnosis confirmed in the reported case?\",\"answer\":\"The patient’s lymph node tissue was biopsied, and pathology confirmed silicone lymphadenopathy using hematoxylin-eosin staining and immunohistochemistry.\"},{\"question\":\"Was any specific treatment given, and what happened afterward?\",\"answer\":\"No special treatment was provided at the time of diagnosis. After one year of follow-up, the patient showed no signs of discomfort.\"}]","Silicone Lymphadenopathy - A Case Report and Literature Review | PDF"]