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Prior studies lacked evidence connecting SRP9 subcellular localization to pancreatic cancer outcome. This study assessed SRP9 localization by immunohistochemical staining of pancreatic tumor surgical specimens, identifying nuclear translocation in a subset of cases. Patients were stratified by nuclear translocation rate to evaluate recurrence-free survival.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/significance-of-signal-recognition-particle-9-nuclear-translocation-implications-for-pancreatic-cancer-prognosis-and-functionality/332150/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/significance-of-signal-recognition-particle-9-nuclear-translocation-implications-for-pancreatic-cancer-prognosis-and-functionality/332150.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main objective regarding SRP9 in pancreatic cancer?","Question",{"text":112,"@type":113},"To examine the relationship between SRP9 nuclear translocation and pancreatic cancer prognosis and related functional aspects.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was SRP9 nuclear translocation assessed in the patient samples?",{"text":117,"@type":113},"SRP9 was detected by immunohistochemical staining in excised pancreatic cancer specimens from surgery cases without preoperative chemotherapy or radiotherapy.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find about survival when patients were grouped by nuclear translocation rate?",{"text":121,"@type":113},"Patients with an SRP9 nuclear translocation rate greater than 50% showed significantly different recurrence-free survival compared with those with a rate of 50% or less (P=0.037).",{"name":123,"@type":110,"acceptedAnswer":124},"What experimental evidence supported the functional relevance of SRP9 nuclear translocation?",{"text":125,"@type":113},"In vitro experiments showed that amino acid-deficient conditions reduced SRP9 nuclear translocation, and RNA immunoprecipitation indicated downregulation of cancer progression and protein translation-related signaling pathways in nuclear-translocated SRP9 splicing variants.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},332150,1790176230,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148,"preview_page_count":4},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","INTERNATIONAL JOURNAL OF ONCOLOGY 65: 74, 2024  \nSignificance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality  \nHIROMICHI SATO 1‑3* , SIKUN MENG 1* , KAZUKI SASAKI2,3 , SHOGO KOBAYASHI2,3 , KANSUKE KIDO4,5 , YOSHIKO TSUJI 1 , YASUKOARAO 1 , YOSHIKO SAITO 1 , YOSHIFUMI IWAGAMI2,3 , DAISAKU YAMADA2,3 , YOSHITO TOMIMARU2,3 , TAKEHIRO NODA2,3 , HIDENORI TAKAHASHI2,3 , DAISUKE MOTOOKA6 , SHIZUKA UCHIDA7 , KEN OFUSA 1,8 , TAROH SATOH2,3 , YUICHIRO DOKI2,3 , HIDETOSHI EGUCHI2,3 , TOMOAKI HARA 1 and HIDESHI ISHII 1  \n1  \nDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan; 2Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan; 3Department of Gastroenterological Surgery, Osaka University Hospital, Osaka 565‑0871, Japan; 4Department of Pathology, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan; 5Department of Pathology, Osaka University Hospital, Osaka 565‑0871, Japan; 6Genome Information Research Center, Research Institute for Microbial Diseases,  \nOsaka University, Osaka 565‑0871, Japan; 7Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, 8  \nDK‑2450 Copenhagen, Denmark; Prophoenix Division, Food and Life‑Science Laboratory, IDEA Consultants, Inc., Osaka 559‑8519, Japan  \nReceived October 21, 2023; Accepted February 28, 2024  \nDOI: 10.3892/ijo.2024.5662  \nAbstract. Signal recognition particles (SRPs) are essential for regulating intracellular protein transport and secretion. Patients with tumors with high SRP9 expression tend to have a poorer overall survival. However, to the best of our knowledge, no reports have described the relationship between SRP9 localiza‑ tion and prognosis in pancreatic cancer. Thus, the present study aimed to investigate this relationship. Immunohistochemical staining for SRP9 using excised specimens from pancreatic cancer surgery cases without preoperative chemotherapy or radiotherapy showed that SRP9 was preferentially expressed in the nucleus of the cancerous regions in some cases, which was hardly detected in other cases, indicating that SRP9 was transported to the nucleus in the former cases. To compare the prognosis of patients with SRP9 nuclear translocation, patients were divided into two groups: Those with a nuclear translocation rate of >50% and those with a nuclear translo‑ cation rate of ≤50% . The nuclear translocation rate of >50% group had a significantly better recurrence‑free survival than  \nCorrespondence to: Professor Hideshi Ishii or Dr Tomoaki Hara, Department of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Yamadaoka 2‑2, Suita, Osaka 565‑0871, Japan  \nE‑[mail: hishii@gesurg.med.osaka](mail: hishii@gesurg.med.osaka)‑[u.ac.jp](u.ac.jp)  \nE‑mail: [thara@cfs.med.osaka](thara@cfs.med.osaka)‑[u.ac.jp](u.ac.jp)  \n*Contributed equally  \nKey words: signal recognition particle 9, pancreatic cancer, nuclear translocation, essential amino acids, splicing variants  \nthe nuclear translocation rate of ≤50% group (P=0.037) . Subsequent in vitro experiments were conducted; notably, the nuclear translocation rate of SRP9 was reduced under amino acid‑deficient conditions, suggesting that multiple factors are involved in this phenomenon. To further study the function of SRP9 nuclear translocation, in vitro experiments were performed by introducing SRP9 splicing variants (v1 and v2) and their deletion mutants lacking C‑terminal regions into MiaPaCa pancreatic cancer cells. The results demonstrated that both splicing variants showed nuclear translocation regardless of the C‑terminal deletions, suggesting the role of the N‑terminal regions. Given that SRP9 is an RNA‑binding protein, the study of RNA immunoprecipitation revealed that signaling pathways","cbCaityNcAgPmb2i","https://ap.wps.com/l/cbCaityNcAgPmb2i","pdf",9182656,"English","# Abstract\n# Introduction","[{\"question\":\"What was the study’s main objective regarding SRP9 in pancreatic cancer?\",\"answer\":\"To examine the relationship between SRP9 nuclear translocation and pancreatic cancer prognosis and related functional aspects.\"},{\"question\":\"How was SRP9 nuclear translocation assessed in the patient samples?\",\"answer\":\"SRP9 was detected by immunohistochemical staining in excised pancreatic cancer specimens from surgery cases without preoperative chemotherapy or radiotherapy.\"},{\"question\":\"What did the study find about survival when patients were grouped by nuclear translocation rate?\",\"answer\":\"Patients with an SRP9 nuclear translocation rate greater than 50% showed significantly different recurrence-free survival compared with those with a rate of 50% or less (P=0.037).\"},{\"question\":\"What experimental evidence supported the functional relevance of SRP9 nuclear translocation?\",\"answer\":\"In vitro experiments showed that amino acid-deficient conditions reduced SRP9 nuclear translocation, and RNA immunoprecipitation indicated downregulation of cancer progression and protein translation-related signaling pathways in nuclear-translocated SRP9 splicing variants.\"}]","Significance of signal recognition particle 9 nuclear translocation - Implications for pancreatic cancer prognosis and functionality | PDF",1789997057,48]