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This case report presents the diagnosis of primary SRCC in the transverse colon of a 10-year-old girl. The patient was investigated for abdominal pain and vomiting, underwent surgical resection and lymph node dissection, and received postoperative standard chemotherapy. Pathology confirmed SRCC with nerve and full-wall infiltration, vascular and lymphatic tumor thrombi, omental nodules, metastases in 18/26 mesenteric nodes, microsatellite stability, and no KRAS/NRAS/BRAF/PIK3CA mutations. After 12 months of follow-up, no tumor progression was observed.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/signet-ring-cell-carcinoma-of-the-transverse-colon-in-a-10-year-old-girl-a-case-report/340495/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/signet-ring-cell-carcinoma-of-the-transverse-colon-in-a-10-year-old-girl-a-case-report/340495.png","ImageObject",300,407,{"name":92,"@type":93},"Seraphina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What condition does the case report describe?","Question",{"text":113,"@type":114},"The report describes primary signet-ring cell carcinoma (SRCC) located in the transverse colon of a 10-year-old girl.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the diagnosis confirmed?",{"text":118,"@type":114},"Computed tomography showed an irregular transverse colon mass with calcifications. Pathological examination after surgical resection confirmed SRCC with nerve and full intestinal wall infiltration, along with metastatic involvement.",{"name":120,"@type":111,"acceptedAnswer":121},"What treatments were given and what was the outcome?",{"text":122,"@type":114},"The patient underwent surgical resection with lymph node dissection, followed by standard chemotherapy for eight cycles. During a 12-month follow-up period, there was no tumor progression or other abnormalities.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},340495,1790464731,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46},962075114101,"https://ap-avatar.wpscdn.com/avatar/e000253a75eb197efd?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780044092746381165","| W | J | G | O | World Journal of\u003Cbr>Gastrointestinal Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2024 December 15; 16(12): 4746-4752  \nDOI: 10.4251/wjgo.v16.i12.4746 ISSN 1948-5204 (online)  \nCASE REPORT  \nSignet-ring cell carcinoma of the transverse colon in a 10-year-old girl: A case report  \nLing Lv, Yuan-Hua Song, Yan Gao, Shuang-Qiong Pu, Zhi-Xiang A, Hong-Fang Wu, Jun Zhou, Yu-Cheng Xie  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade C, Grade C, Grade C, Grade D, Grade D Novelty: Grade B, Grade B, Grade B, Grade C, Grade C  \nCreativity or Innovation: Grade B, Grade C, Grade C, Grade C, Grade C  \nScientific Significance: Grade B, Grade B, Grade B, Grade C, Grade C  \nP-Reviewer: Kanda T; Nakamura T; Xu DH  \nReceived: August 5, 2024  \nRevised: September 29, 2024  \nAccepted: October 18, 2024  \nPublished online: December 15, 2024  \nProcessing time: 98 Days and 17.5 Hours  \nLing Lv, Yan Gao, Shuang-Qiong Pu, Zhi-Xiang A, Hong-Fang Wu, Jun Zhou, Yu-Cheng Xie,  \nDepartment of Pathology, Kunming Children’s Hospital, Kunming 650028, Yunnan Province, China  \nYuan-Hua Song, Department of Oncology, Kunming Children’s Hospital, Kunming 650028, Yunnan Province, China  \nCo-first authors: Ling Lv and Yuan-Hua Song.  \nCo-corresponding authors: Jun Zhou and Yu-Cheng Xie.  \nCorresponding author: Yu-Cheng Xie, Chief Physician, Department of Pathology, Kunming Children’s Hospital, No. 288 Qianxing Road, Kunming 650028, Yunnan Province, China.  \n[7151290@qq.com](7151290@qq.com)  \nAbstract  \nBACKGROUND  \nSignet-ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer. The incidence of primary colonic SRCC is relatively rare in pediatric patients, with a limited number of reported cases currently available. The prognosis for this specific tumor type is unfavorable, and the preoperative diagnosis presents challenges, potentially leading to misdiagnosis. This case report describes the diagnosis of primary SRCC in the colon of a 10-year-old girl.  \nCASE SUMMARY  \nThe patient was admitted to the hospital due to abdominal pain and vomiting. A computed tomography scan revealed an irregular mass with soft tissue density in her transverse colon, showing uneven density and multiple calcifications. The patient underwent surgical resection of the affected bowel and lymph node dissection, which was confirmed by pathological examination to be SRCC infiltrating both nerves and the entire intestinal wall. Additionally, tumor thrombus formation was observed in blood vessels and lymphatic vessels, multiple cancerous nodules were found in the omentum, and metastasis to 18 of 26 mesenteric lymph nodes examined. Immunohistochemistry for mismatch repair gene protein demonstrated microsatellite stability. No mutations in KRAS, NRAS, BRAF, or PIK3CA genes were detected through molecular pathology analysis. After surgery, she received standard chemotherapy for 8 cycles without tumor progression or other abnormalities during a 12-month follow-up period.  \n WJGO  [https://www.wjgnet.com](https://www.wjgnet.com) 4746 December 15, 2024  Volume 16  Issue 12   \nLv L et al. A pediatric SRCC  \nCONCLUSION  \nPrimary colonic SRCC is a rare malignant tumor with atypical clinical symptoms, and timely identification and intervention are crucial for improving the prognosis.  \nKey Words: Signet ring cell cancer; Colon; Pediatric; Pathological presentation; Case report  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: We present a case of primary signet-ring cell carcinoma of the colon in a 10-year-old girl. Pediatric signet-ring cell carcinoma is an exceptionally rare condition with atypical clinical symptoms, making early diagnosis challen","cbCaia4MVYnb2i6x","https://ap.wps.com/l/cbCaia4MVYnb2i6x","pdf",10761857,"English","# Abstract\n## Background\n## Case Summary\n## Conclusion\n# Core Tip\n# Citation\n# Introduction\n# Chief Complaints","[{\"question\":\"What condition does the case report describe?\",\"answer\":\"The report describes primary signet-ring cell carcinoma (SRCC) located in the transverse colon of a 10-year-old girl.\"},{\"question\":\"How was the diagnosis confirmed?\",\"answer\":\"Computed tomography showed an irregular transverse colon mass with calcifications. Pathological examination after surgical resection confirmed SRCC with nerve and full intestinal wall infiltration, along with metastatic involvement.\"},{\"question\":\"What treatments were given and what was the outcome?\",\"answer\":\"The patient underwent surgical resection with lymph node dissection, followed by standard chemotherapy for eight cycles. During a 12-month follow-up period, there was no tumor progression or other abnormalities.\"}]","Signet-ring cell carcinoma of the transverse colon in a 10-year-old girl - A case report | PDF",1790036872]