[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-327544-105":59,"doc-detail-327544-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","signaling-cancer-cell-plasticity-and-intratumor-heterogeneity","Signaling, cancer cell plasticity, and intratumor heterogeneity","","Cancer’s complexity is shaped by intratumor heterogeneity and the dynamic nature of cancer cell plasticity, which hinder effective management. Tumor variability reflects the presence of diverse cancer cell populations that influence progression, spread, and treatment resistance. Central to this variability is cellular plasticity, the ability to shift molecular and cellular identity in response to environmental and genetic changes, driving persistence and progression. Signal transduction networks, including pathways governing epithelial-to-mesenchymal transition and metabolic remodeling, further shape cancer evolution. The editorial outlines emerging evidence and calls for continued research, introducing a series focused on therapeutic opportunities.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/signaling-cancer-cell-plasticity-and-intratumor-heterogeneity/327544/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/signaling-cancer-cell-plasticity-and-intratumor-heterogeneity/327544.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does intratumor heterogeneity affect cancer progression and treatment?","Question",{"text":112,"@type":113},"Intratumor heterogeneity describes genetically and phenotypically distinct cancer cell populations within the same tumor, influencing tumor growth, metastasis, and resistance to therapies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is cellular plasticity in cancer?",{"text":117,"@type":113},"Cellular plasticity is the intrinsic ability of cancer cells to alter their molecular and cellular identity in response to environmental and genetic changes, supporting persistence and progression.",{"name":119,"@type":110,"acceptedAnswer":120},"Which signaling processes are highlighted as shaping cancer evolution?",{"text":121,"@type":113},"The text emphasizes signal transduction pathways that drive epithelial-to-mesenchymal transition and metabolic remodeling, which help shape the evolutionary path of cancer cells.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},327544,1790723429,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Cordani etal. Cell Communication and Signaling (2024) 22:255  \n[https://doi.org/10.1186/s12964-024-01643-5](https://doi.org/10.1186/s12964-024-01643-5)  \nCell Communication and Signaling  \nEDITORIAL Open Access  \nSignaling, cancer cell plasticity, and intratumor heterogeneity  \nMarco Cordani 1,2*, Ilaria Dando3*, Giulia Ambrosini3* and Pedro González-Menéndez4,5,6*  \nAbstract  \nCancer’s complexity is in part due to the presence of intratumor heterogeneity and the dynamic nature of cancer cell plasticity, which create substantial obstacles in effective cancer management. Variability within a tumor arises from the existence of diverse populations of cancer cells, impacting the progression, spread, and resistance to treatments. At the core of this variability is the concept of cellular plasticity-the intrinsic ability of cancer cells to alter their molecular and cellular identity in reaction to environmental and genetic changes. This adaptability is a cornerstone of cancer’s persistence and progression, making it a formidable target for treatments. Emerging studies have emphasized the critical role of such plasticity in fostering tumor diversity, which in turn influences the course of the disease and the effectiveness of therapeutic strategies. The transformative nature of cancer involves a network of signal transduction pathways, notably those that drive the epithelial-to-mesenchymal transition and metabolic remodeling, shaping the evolutionary path of cancer cells. Despite advancements, our understanding of the precise molecular machinations and signaling networks driving these changes is still evolving, underscoring the necessity for further research. This editorial presents a series entitled “Signaling Cancer Cell Plasticity and Intratumor Heterogeneity” in Cell Communication and Signaling, dedicated to unraveling these complex processes and proposing new avenues for therapeutic intervention.  \n*Correspondence: Marco Cordani[mcordani@ucm.es](mcordani@ucm.es)[ ](mcordani@ucm.es)Ilaria Dando [ilaria.dando@univr.it](ilaria.dando@univr.it)[ ](ilaria.dando@univr.it)Giulia Ambrosini  \n[giulia.ambrosini@univr.it](giulia.ambrosini@univr.it)[ ](giulia.ambrosini@univr.it)Pedro González-Menéndez [gonzalezmpedro@uniovi.es](gonzalezmpedro@uniovi.es)  \n1Department of Biochemistry and Molecular Biology, Faculty of Biology, Complutense University, Madrid 28040, Spain  \n2Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid 28040, Spain  \n3Department of Neuroscience, Biomedicine and Movement Sciences, Biochemistry Section, University of Verona, Verona 37134, Italy 4Departamento de Morfología y Biología Celular, School of Medicine, Julián Claveria 6, Oviedo 33006, Spain  \n5Instituto Universitario de Oncología del Principado de Asturias (IUOPA), University of Oviedo, Oviedo 33006, Spain  \n6Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias (HUCA), Oviedo 33011, Spain  \nIntroduction  \nThe enigmatic and complex features of cancer pose significant obstacles for both researchers and healthcare professionals. Among these challenges, the issue of intratumor heterogeneity stands out as a particularly insurmountable obstacle. This phenomenon, often a precursor to cancer evolution and tumor progression, significantly hampers effective therapeutic strategies [1, 2]. Intratumor heterogeneity refers to the coexistence of genetically and phenotypically distinct cancer cell populations within a single tumor mass, with implications for tumor growth, metastasis, and therapeutic resistance [2]. For instance, genetic analysis of tumor samples from lung and kidney cancers has revealed considerable intratumor genetic heterogeneity, which is associated with increased resistance to targeted therapies [3, 4]. At the heart of intratumor heterogeneity lies cellular plasticity  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International Li","cbCail0TWBjRd2p9","https://ap.wps.com/l/cbCail0TWBjRd2p9","pdf",2603149,"English","# Introduction\n# Editorial scope and objectives","[{\"question\":\"How does intratumor heterogeneity affect cancer progression and treatment?\",\"answer\":\"Intratumor heterogeneity describes genetically and phenotypically distinct cancer cell populations within the same tumor, influencing tumor growth, metastasis, and resistance to therapies.\"},{\"question\":\"What is cellular plasticity in cancer?\",\"answer\":\"Cellular plasticity is the intrinsic ability of cancer cells to alter their molecular and cellular identity in response to environmental and genetic changes, supporting persistence and progression.\"},{\"question\":\"Which signaling processes are highlighted as shaping cancer evolution?\",\"answer\":\"The text emphasizes signal transduction pathways that drive epithelial-to-mesenchymal transition and metabolic remodeling, which help shape the evolutionary path of cancer cells.\"}]","Signaling, cancer cell plasticity, and intratumor heterogeneity | PDF",1789977481,23]