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Provides transfusion guidance for RBC therapy and exchange transfusion thresholds, considerations for MRSA coverage, and a medication dosing table plus references.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/sickle-cell-disease-scd-acute-chest-syndrome-acs-pathway-ip-management-december-2025/332464/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/sickle-cell-disease-scd-acute-chest-syndrome-acs-pathway-ip-management-december-2025/332464.png","ImageObject",300,407,{"name":42,"@type":43},"Emma Mercer","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What criteria indicate PICU admission for SCD acute chest syndrome?","Question",{"text":63,"@type":64},"PICU admission criteria include an Aflac ICU transfer guideline and a need for exchange transfusion.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What are key discharge criteria for patients improving from ACS?",{"text":68,"@type":64},"Discharge requires tolerating oral intake with adequate oral pain control, being afebrile for at least 24 hours, stable hemoglobin, and stability on the patient’s baseline oxygen requirement.",{"name":70,"@type":61,"acceptedAnswer":71},"How does the pathway guide transfusion choices in ACS?",{"text":72,"@type":64},"RBC transfusion is intended to treat ACS with hypoxia, balancing benefits and individual risk. If transfusion is chosen, simple transfusion is used when Hb \u003C 9, while Hb ≥ 9 or rapid deterioration with worsening respiratory distress and infiltrates may prompt exchange transfusion with a target HbS% \u003C 30%.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332464,1790229244,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":26,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":97},962084925502,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","|  |  |  |  |\n| --- | --- | --- | --- |\n|  | Sickle Cell Disease (SCD) Acute Chest Syndrome (ACS) Pathway IP Management\u003Cbr>December 2025 |  |  |\n|  |  |  |  |\n|  | Work Up |  |  |\n| \u003Cbr>\u003Cbr>Criteria for PICU admission\u003Cbr>• Aflac ICU Transfer Guideline\u003Cbr>• Need for exchange transfusion\u003Cbr>\u003Cbr>\u003Cbr>Stable\u003Cbr>\u003Cbr>\u003Cbr>Begin General Care²\u003Cbr>\u003Cbr>\u003Cbr>Standard\u003Cbr>ampicillin + azithromycin\u003Cbr>Surgical Splenectomy, CVAD, or PCN Allergy\u003Cbr>levofloxacin\u003Cbr>\u003Cbr>Improving/Discharge\u003Cbr>Discharge Criteria:\u003Cbr>• Tolerating orals; adequate pain control on oral regimen; afebrile ≥24h; stable Hb; stable on baseline oxygen requirement\u003Cbr>• Transition to oral: amoxicillin or levofloxacin\u003Cbr>• Consult Case Mgmt for outpatient medications\u003Cbr>\u003Cbr>\u003Cbr>\u003Cbr>• SCD clinic within 4wks\u003Cbr>• Refer to SCD-Pulm (if not already established) for ACS requiring PICU, history of asthma or RAD, or recurrent episodes |  | ¹ Definition Acute illness characterized by new pulmonary infiltrate (non-atelactatic consolidation) on CXR plus fever (≥ 38.3C) and/or respiratory signs/symptoms (cough, shortness of breath, chest pain, crackles, hypoxia, etc) ² General Care • Maintain euvolemia with IV fluids at 3/4 to 1x maintenance rate. Decrease IVF rate as clinical status improves and oral intake increases.\u003Cbr>• Consider PT consult for early ambulation\u003Cbr>• Consider VTE prophylaxis, especially in patients >18yo, previous history of VTE, CVL, or other risk factors\u003Cbr>• See SCD Inpatient Pain Guideline\u003Cbr>Daily Labs\u003Cbr>• CBCd\u003Cbr>• Retic\u003Cbr>• Ensure active Type & Screen ³ Respiratory Support • Keep oxygen saturations ≥ 93%\u003Cbr>• All patients should receive positive expiratory pressure (PEP) and incentive spirometer (IS)\u003Cbr>Consider the following:\u003Cbr>• Scheduled albuterol if history of asthma, reactive airway disease, or history of severe ACS\u003Cbr>• 3% inhaled saline and/or chest physiotherapy (CPT) for patients with significant crackles/mucous\u003Cbr>• Pulmonary consult based on severity, history of recurrence, or other lung disease\u003Cbr>• Positive pressure ventilation (PPV) such as HFNC or BiPAP for increasing WOB, O2 needs, or previous recommendations to start PPV at dx of ACS ⁴  Non Improvement Criteria  If:\u003Cbr>• Increasing respiratory support\u003Cbr>•Worsening imaging\u003Cbr>• Hemodynamic instability or concern for sepsis Then:\u003Cbr>•Consider Watcher Huddle ⁵ Transfusion • RBC Transfusion has benefits to treat ACS with hypoxia. Balance benefits vs individual risk assessment for each patient\u003Cbr>• Assess Hb, retic, HbS%, alloimmunization history, level of respiratory support\u003Cbr>If decision is made to transfuse and:\u003Cbr>• Hb \u003C 9, can proceed with simple transfusion\u003Cbr>• Hb ≥ 9 and/or rapid deterioration characterized by increasing oxygen needs, worsening respiratory distress, progressive pulmonary infiltrates, and/or decline in Hb despite simple transfusions, consider exchange transfusion with a target HbS% \u003C30% ⁶ Consider vancomycin if... • Moderate to severe parapneumonic effusion\u003Cbr>• Empyema\u003Cbr>• Other concern for MRSA (obtain nasal MRSA PCR)\u003Cbr>Page 1 of 2 |  |\n| This document was developed and approved by Aflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta, including its content and recommendations. Please consult the document owner for questions ( Neha Desai, DO Clinical Director: Marianne Yee, MD) . This is general guidance and is not applicable to all patients or settings of care; it may need to be adapted for specific patient/practitioner circumstances. It does not represent a professional care standard governing providers' obligation to patients. Ultimately the patient’s physician must determine the most appropriate care. Children’s Healthcare of Atlanta is not responsible for any errors or omissions in the clinical pathways or for any outcomes a patient might experience where a clinician used a pathway in the care for that patient. © 2025 Children’s Healthcare of Atlanta, Inc. |  |  |  |\n\n\n|  |  |  |  |  |  |  |  |\n| --- | --- | --- | --- | --- | --- | --- | --- ","cbCairI3zVYgczOJ","https://ap.wps.com/l/cbCairI3zVYgczOJ","pdf",229415,"English","# Work Up\n## Criteria for PICU admission\n## Stable - Begin General Care\n## Standard medication regimen\n## Improving/Discharge criteria\n## Respiratory support\n## Non Improvement criteria\n## Transfusion\n## Consider vancomycin","[{\"question\":\"What criteria indicate PICU admission for SCD acute chest syndrome?\",\"answer\":\"PICU admission criteria include an Aflac ICU transfer guideline and a need for exchange transfusion.\"},{\"question\":\"What are key discharge criteria for patients improving from ACS?\",\"answer\":\"Discharge requires tolerating oral intake with adequate oral pain control, being afebrile for at least 24 hours, stable hemoglobin, and stability on the patient’s baseline oxygen requirement.\"},{\"question\":\"How does the pathway guide transfusion choices in ACS?\",\"answer\":\"RBC transfusion is intended to treat ACS with hypoxia, balancing benefits and individual risk. If transfusion is chosen, simple transfusion is used when Hb \\u003c 9, while Hb ≥ 9 or rapid deterioration with worsening respiratory distress and infiltrates may prompt exchange transfusion with a target HbS% \\u003c 30%.\"}]","Sickle Cell Disease (SCD) Acute Chest Syndrome (ACS) Pathway - IP Management - December 2025 | PDF",1789998323]