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Results evaluated SCA frequency, co-morbid risks, and outcomes across case and control groups, highlighting differences in neonatal weight and factors influencing birth 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was the study designed to evaluate in pregnant Saudi women with sickle cell anemia?","Question",{"text":63,"@type":64},"The study evaluated gestational maturity and birth weight of babies born to Saudi mothers with SCA in the Jazan region.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were data and birth weight collected?",{"text":68,"@type":64},"Data were collected using a semi-structured questionnaire during a case-control study in three hospitals, and birth weight was then measured after delivery.",{"name":70,"@type":61,"acceptedAnswer":71},"What major outcomes were compared between the SCA group and the control group?",{"text":72,"@type":64},"The study compared birth weight distribution (including low birth weight proportions) and gestational age between affected mothers and non-SCA 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birth weight and gestational maturity  \nEbtihal Elameen Eltyeba,*, Alanoud Ibrahim Mokhashab, Ali Ali Al-Makramania,  \nMaha Murtada Abdelmageedc, Randa Amin Basheerd  \naDepartment of Paediatrics, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia; bFamily Medicine Program at Jazan, Saudi Arabia; cDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Jazan University, Saudi Arabia; dDepartment of Nursing, Farasan University College, Jazan University, Saudi Arabia  \nAbstract  \nBackground: It is well documented that sickle cell anemia (SCA) in pregnancy increases the risk of problems that can influence the growth and maturation of the newborn. To assess the gestational maturity and birth weight of babies born to Saudi mothers with SCA in the Jazan region.  \nMethods: A case-control study was conducted in three hospitals in the Jazan region. An interview with a semi-structured questionnaire was used to collect data from the participants’ women, and then the birth weight was taken.  \nResults: Of 187 delivered women, 20.3% had SCA (13% had sickle cell disease, and the remaining had sickle cell trait) . Among the 38 affected mothers, 15.7% were considered to have an additional risk (7 .9% had diabetes mellitus, 5.3% had hypertension, and 2.6% were smokers) . The mean birth weight was 2.95 ± 0.40 kg and 2.99 ± 0.55 kg in the case and control groups, respectively. However, the low birth weight babies constitute 31% of the delivered babies in the SCA group with a weight of 2.33 ± 0.16 kg and 15% of the control group with a mean weight of 2.16 ± 0.30 kg. The gestational age was 39.36 ± 1.02 weeks in the SCA group compared to 39.5 ± 1.17 weeks in the control group. Maternal age and hypertension significantly influence the birth weight in the SCA group compared to the influence of diabetes mellitus on the birth weight in the control group.  \nConclusion: This study indicates that SCA in pregnant mothers influences birth weight, which is more impacted by maternal age and co-morbidities. Therefore, a multidisciplinary approach must monitor these risky pregnancies well to avoid undesirable neonatal outcomes.  \nKeywords: Birth weight; Gestational maturity; Neonatal outcome; Saudi mothers; Sickle cell anemia  \n1. INTRODUCTION  \nSickle cell anemia (SCA) is a condition brought on by faulty mutant hemoglobin production that leads to tissue ischemia and infarction throughout the body in SCA patients. SCA is the most prevalent hemoglobinopathy during pregnancy that might cause prematurity and low birth weight (LBW) .1,2 Other maternal factors, such as dietary status, smoking, and drug use, as well as fetal and placental factors, such as genetic makeup, affect fetal growth and add more risks and adverse neonatal outcomes in mothers with SCA.3,4 In addition, SCA mothers experience an aggravation of the physiological changes of pregnancy, such asan increase in metabolic demand, blood viscosity, and hypercoagulability, which increases the risk of complications like avaso-occlusive crisis and thrombo-embolic events.5  \n*Address correspondence. Dr. Ebtihal Elameen Eltyeb, Department of Paediatrics, Jazan University, P.O. Box: 2349. Postal Code: 82621, Jazan, Saudi Arabia. [E-mail addresses: bebotyb@gmail.com](E-mail addresses: bebotyb@gmail.com), [eeltyeb@jazanu.edu.sa](eeltyeb@jazanu.edu.sa) (E. E. Eltyeb). Conflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2023) 86: 892-896.  \nReceived May 24, 2023; accepted July 14, 2023.  \ndoi: 10. 1097/JCMA.0000000000000974.  \nCopyright © 2023, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4","cbCaiqN7uiqxFquI","https://ap.wps.com/l/cbCaiqN7uiqxFquI","pdf",386573,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# 1. Introduction\n# 2. Methods\n## 2.1. Context of the study","[{\"question\":\"What was the study designed to evaluate in pregnant Saudi women with sickle cell anemia?\",\"answer\":\"The study evaluated gestational maturity and birth weight of babies born to Saudi mothers with SCA in the Jazan region.\"},{\"question\":\"How were data and birth weight collected?\",\"answer\":\"Data were collected using a semi-structured questionnaire during a case-control study in three hospitals, and birth weight was then measured after delivery.\"},{\"question\":\"What major outcomes were compared between the SCA group and the control group?\",\"answer\":\"The study compared birth weight distribution (including low birth weight proportions) and gestational age between affected mothers and non-SCA controls.\"}]","Sickle cell anemia in pregnant Saudi women and its impact on birth weight and gestational maturity | PDF",1790677634,13]