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ST is compared between 176 CC patients and 82 healthy controls, with follow-up in 49 gastroesophageal reflux-associated cough (GERC) and 86 non-GERC cases. ST is shorter in CC, especially in GERC, correlates with reflux symptom scores, and predicts need for anti-reflux therapy intensification.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/shorten-swallowing-time-and-its-implication-in-patients-with-chronic-cough-a-prospective-observational-study/422864/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/shorten-swallowing-time-and-its-implication-in-patients-with-chronic-cough-a-prospective-observational-study/422864.png","ImageObject",300,407,{"name":92,"@type":93},"anakgang17","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the purpose of measuring swallowing time (ST) in chronic cough?","Question",{"text":113,"@type":114},"To evaluate clinical utility of ST for etiological assessment and management of chronic cough, particularly where swallowing dysfunction is related to laryngeal hypersensitivity.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does ST differ between chronic cough patients and healthy controls?",{"text":118,"@type":114},"ST is significantly shorter in chronic cough patients than in healthy controls, with statistically significant differences across etiological subtypes.",{"name":120,"@type":111,"acceptedAnswer":121},"How well does ST predict treatment intensification in GERC patients compared with questionnaires?",{"text":122,"@type":114},"Shorter ST is associated with proximal reflux events and greater need for intensified anti-reflux therapy, and ST shows superior predictive accuracy over HARQ and RSI scores in GERC patients.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},422864,1790900340,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090883568,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Zhang et al. BMC Pulmonary Medicine (2026) 26:2  \n[https://doi.org/10.1186/s12890-025-04015-y](https://doi.org/10.1186/s12890-025-04015-y)  \nBMC Pulmonary Medicine  \nRESEARCH Open Access  \nShorten swallowing time and its implication  in patients with chronic cough: a prospective observational study  \nLi Zhang 1,2†, Jing Pan2,3†, Wenbo Shi2†, Mengru Zhang4, Alimire Aierken2, Ran Dong2, Qiang Chen2 and Zhongmin Qiu2*  \nAbstract  \nBackground Patients with chronic cough (CC) frequently exhibit swallowing dysfunction related to laryngeal hypersensitivity. This study aimed to evaluate the clinical utility of swallowing time (ST) measurement in theetiological assessment and management of CC.  \nMethods The ST was measured in 176 patients with CC and 82 healthy controls. Follow-up assessments were conducted among 49 patients with gastroesophageal reflux-associated cough (GERC) and 86 with other causes of CC (non-GERC) . Associations between ST and clinical features were analyzed, and the predictive performance of  \nST for guiding treatment intensification was evaluated in GERC patients and compared with the Hull Airway Reflux Questionnaire (HARQ) and Reflux Symptom Index (RSI) .  \nResults The ST was significantly shorter in CC than in healthy controls (1 .167 ± 0.446 s vs. 1.798 ± 0.721 s, p \u003C 0. 001), and varied significantly among etiological subtypes (p = 0 . 019) . ST was notably reduced in GERC compared to nonGERC patients, showing a specificity of 85 . 7% but sensitivity of 46 . 5% . In GERC patients, ST correlated negatively with RSI and HARQ scores, and positively with capsaicin cough threshold (C5) . Shorter ST (\u003C 1.015 s) was associated with proximal reflux events and greater need for intensified anti-reflux therapy (χ2 = 17 . 686, p \u003C 0. 001) . ST also exhibited superior predictive accuracy over HARQ and RSI scores.  \nConclusion Swallowing reflex hypersensitivity is prevalent in CC, especially in GERC. ST assessment provides valuable information for etiological differentiation and helps guide optimal treatment intensification in GERC patients. Keywords Swallowing time, Chronic cough, Gastroesophageal reflux, Swallowing reflex, Irritable larynx  \n†Li Zhang, Jing Pan and Wenbo Shi contributed equally to this work.  \n*Correspondence: Zhongmin Qiu [qiuzhongmin@tongji.edu.cn](qiuzhongmin@tongji.edu.cn)  \n1Department of Respiratory Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai 200072, China  \n2Department of Pulmonary and Critical Care Medicine, School of Medicine, Tongji Hospital, Tongji University, No. 389 Xincun Road, Shanghai 200065, China  \n3Business and Economics, Shanghai University of International, No. 620 Gubei Road, Shanghai 201620, China  \n4Centre for Clinical Science, Respiratory Medicine, Hull York Medical School, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire, UK  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icense","cbCaicRpa2KqrURR","https://ap.wps.com/l/cbCaicRpa2KqrURR","pdf",1865078,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Main Text Background","[{\"question\":\"What is the purpose of measuring swallowing time (ST) in chronic cough?\",\"answer\":\"To evaluate clinical utility of ST for etiological assessment and management of chronic cough, particularly where swallowing dysfunction is related to laryngeal hypersensitivity.\"},{\"question\":\"How does ST differ between chronic cough patients and healthy controls?\",\"answer\":\"ST is significantly shorter in chronic cough patients than in healthy controls, with statistically significant differences across etiological subtypes.\"},{\"question\":\"How well does ST predict treatment intensification in GERC patients compared with questionnaires?\",\"answer\":\"Shorter ST is associated with proximal reflux events and greater need for intensified anti-reflux therapy, and ST shows superior predictive accuracy over HARQ and RSI scores in GERC patients.\"}]","Shorten swallowing time and its implication in patients with chronic cough - a prospective observational study | PDF",1790629112,25]