[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-427420-105":59,"doc-detail-427420-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","sex-stratified-skeletal-treatment-effects-from-the-invest-in-bone-health-randomized-clinical-trial-abstract","SEX-STRATIFIED SKELETAL TREATMENT EFFECTS FROM THE INVEST IN BONE HEALTH RANDOMIZED CLINICAL TRIAL - Abstract","","INVEST in Bone Health Trial (NCT04076618) compared weight loss (10% caloric restriction), weight loss plus weighted vest use (8 hours/day), and weight loss plus progressive resistance training (three supervised sessions weekly) on bone health outcomes in older adults. A secondary 12-month analysis evaluated sex-stratified skeletal effects, including volumetric and areal bone mineral density and bone turnover biomarkers (P1NP, CTX). Among 150 adults (74.7% women), women showed attenuated total hip vBMD loss with WL+VEST and higher P1NP versus WL; WL+RT also increased P1NP in women. In men, WL+VEST worsened femoral neck aBMD loss; overall compliance did not differ by sex.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sex-stratified-skeletal-treatment-effects-from-the-invest-in-bone-health-randomized-clinical-trial-abstract/427420/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sex-stratified-skeletal-treatment-effects-from-the-invest-in-bone-health-randomized-clinical-trial-abstract/427420.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-14","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What treatments were compared in the INVEST in Bone Health Trial?","Question",{"text":112,"@type":113},"The trial compared weight loss alone (caloric restriction targeting 10% weight loss), weight loss plus weighted vest use, and weight loss plus progressive resistance training.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which bone health outcomes were assessed at 12 months?",{"text":117,"@type":113},"Outcomes included volumetric and areal bone mineral density and biomarkers of bone turnover: P1NP and CTX.",{"name":119,"@type":110,"acceptedAnswer":120},"Did intervention compliance differ between men and women?",{"text":121,"@type":113},"No sex differences were noted in intervention compliance, including weight loss, vest wear-time, and resistance training session attendance.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427420,1790814592,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Innovation in Aging, 2025, Vol. 9, No. S2 733  \nAbstract citation ID: igaf122.2495  \nSEX-STRATIFIED SKELETAL TREATMENT EFFECTS FROM THE INVEST IN BONE HEALTH RANDOMIZED CLINICAL TRIAL  \nKristen Beavers1, Delanie Lynch1, Marjorie Howard1, Leon Lenchik1, Ashley Weaver1, Sarah Wherry2, Barbara Nicklas1, and Daniel Beavers3, 1. Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States, 2. University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States, 3. Wake Forest University, Winston Salem, North Carolina, United States  \nThe main goal of the INVEST in Bone Health Trial (NCT04076618) was to compare effects of weight loss (WL) alone (caloric restriction targeting 10% WL), WL plus weighted vest use (WL+VEST; 8 hours/day, weight replacement titrated up to 10% total WL), or WL plus progressive resistance training (WL+RT; 3 supervised sessions/week) on bone health indicatorsin older adults. As women are more likely to develop osteoporosis and experience fractures, the purpose of this secondary analysis was to present 12-month skeletal treatment effects [including: volumetric bone mineral density (vBMD), areal (a) BMD, and biomarkers of bone turnover (procollagen type 1 N-terminal propeptide (P1NP) and C-terminal cross-linked telopeptide (CTX))] stratified by sex. 150 (74.7% women) older adults (66.4±4.6 years; 68.6% White) living with overweight or obesity (BMI: 33.6±3.3kg/m2) were randomized (n = 50/ group) with 133 (89%) completing the trial. Baseline age, weight, height, cardiovascular disease prevalence, and physical activity energy expenditure were higher in men than women. No sex differences were noted in intervention compliance (e.g., weight loss, vest wear-time, RT session attendance) . In women, WL+VEST attenuated total hip vBMD loss [estimated treatment difference (ETD): +0.0019 mg/cm3 (0.0005, 0.0034); p = 0.008] and increased P1NP [ETD: +7.6 µg/L (0.8, 14.3); p = 0.014] versus WL alone. WL+RT also increased P1NP versus WL alone [ETD: +5.3 µg/L (-0.3, 10.9); p = 0.028] in women. Conversely, in men WL+VEST exaggerated femoral neck aBMD loss versus WL alone [ETD: -0.038 g/cm2 (-0.066, -0.009); p = 0.012] . In older women, but not men, undergoing caloric restriction, weighted vest use may reduce bone loss via increased bone formation.","cbCaiflZsXYRjvls","https://ap.wps.com/l/cbCaiflZsXYRjvls","pdf",663635,"English","# Background\n## Study aim and design\n# Participants and measures\n## Randomization and completion\n## Bone outcomes and biomarkers\n# Results by sex\n## Women: effects of WL+VEST and WL+RT\n## Men: effects of WL+VEST\n# Conclusion","[{\"question\":\"What treatments were compared in the INVEST in Bone Health Trial?\",\"answer\":\"The trial compared weight loss alone (caloric restriction targeting 10% weight loss), weight loss plus weighted vest use, and weight loss plus progressive resistance training.\"},{\"question\":\"Which bone health outcomes were assessed at 12 months?\",\"answer\":\"Outcomes included volumetric and areal bone mineral density and biomarkers of bone turnover: P1NP and CTX.\"},{\"question\":\"Did intervention compliance differ between men and women?\",\"answer\":\"No sex differences were noted in intervention compliance, including weight loss, vest wear-time, and resistance training session attendance.\"}]","SEX-STRATIFIED SKELETAL TREATMENT EFFECTS FROM THE INVEST IN BONE HEALTH RANDOMIZED CLINICAL TRIAL - Abstract | PDF",1790643804]