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Using the companion dog as a translational model, the study investigates age-related metabolic changes and links them to disease. Machine-learning models trained on longitudinal Dog Aging Project data build a comprehensive aging metabolome, incorporating metabolomics, blood chemistry, and complete blood counts for precision cohorts and extensive demographic, health, and lifestyle data from pack cohorts.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sex-sterilization-and-metabolic-profiles-shape-aging-trajectories-and-age-related-disease-risk-in-dogs/427805/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sex-sterilization-and-metabolic-profiles-shape-aging-trajectories-and-age-related-disease-risk-in-dogs/427805.png","ImageObject",300,407,{"name":92,"@type":93},"Alex Sinclair","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-20","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are dogs used to study aging metabolite changes?","Question",{"text":113,"@type":114},"Dogs share a similar environment with humans, develop age-related multimorbidity, and have shorter lifespans, making them suitable for studying aging dynamics.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What data sources were used to model the aging metabolome?",{"text":118,"@type":114},"The work uses longitudinal Dog Aging Project information, including metabolomics, blood chemistry, and complete blood counts from the Precision cohort, plus demographic, health, and lifestyle variables from the Pack cohort.",{"name":120,"@type":111,"acceptedAnswer":121},"How do sex and sterilization relate to age-related disease risk in the findings?",{"text":122,"@type":114},"The results indicate differences in disease risk patterns associated with aging and age-related conditions, including osteoarthritis, and report that no significant sex-based differences were observed while sterilized dogs showed increased risk.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},427805,1791016990,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":81},1099523882182,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","852 Innovation in Aging, 2025, Vol. 9, No. S2  \nshifts associated with aging and age-related conditions, including osteoarthritis (OA), where metabolites such as dimethylglycine and betaine were associated with disease risk. Additionally, large, giant, and mixed breeds, as well as sterilized dogs, exhibited an increased risk of OA, whereas no significant sex-based differences were observed. These findings provide new insights into the metabolic underpinnings of age-related diseases and highlight the influence of body size and sterilization status on disease risk.  \nAbstract citation ID: igaf122.2885  \nSEX, STERILIZATION AND METABOLIC PROFILES  \nSHAPE AGING TRAJECTORIES AND AGE-RELATED  \nDISEASE RISK IN DOGS  \nFilippo Artoni1, Ben Harrison2, Laura Corlin3, and Daniel Promislow1, 1. Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, Massachusetts, United States, 2. University of Washington, Seattle, Washington, United States, 3. Tufts University, Medford, Massachusetts, United States  \nThe metabolome is a highly conserved network of small molecules that plays a central role in cellular metabolism and signaling, yet its role in aging remains poorly understood. Here, we leverage the companion dog as a powerful translational model to investigate age-related metabolic changes and their relationship with disease. Dogs share a similar environment with humans, exhibit age-related multimorbidity, and have shorter lifespans, making them ideal for studying aging dynamics. Using machine-learning models trained on longitudinal data from the Dog Aging Project (DAP), we constructed a comprehensive model of the aging metabolome. Our dataset included metabolomics, blood chemistry, and complete blood counts from DAP’s Precision cohort (n = 976), along with demographic, health, and lifestyle data from DAP’s Pack cohort (>50,000) . We identified metabolic","cbCaictY11TUhiqG","https://ap.wps.com/l/cbCaictY11TUhiqG","pdf",763057,"English","# SEX, STERILIZATION AND METABOLIC PROFILES\n## Shape Aging Trajectories and Age-Related Disease Risk in Dogs","[{\"question\":\"Why are dogs used to study aging metabolite changes?\",\"answer\":\"Dogs share a similar environment with humans, develop age-related multimorbidity, and have shorter lifespans, making them suitable for studying aging dynamics.\"},{\"question\":\"What data sources were used to model the aging metabolome?\",\"answer\":\"The work uses longitudinal Dog Aging Project information, including metabolomics, blood chemistry, and complete blood counts from the Precision cohort, plus demographic, health, and lifestyle variables from the Pack cohort.\"},{\"question\":\"How do sex and sterilization relate to age-related disease risk in the findings?\",\"answer\":\"The results indicate differences in disease risk patterns associated with aging and age-related conditions, including osteoarthritis, and report that no significant sex-based differences were observed while sterilized dogs showed increased risk.\"}]","SEX, STERILIZATION AND METABOLIC PROFILES - Shape Aging Trajectories and Age-Related Disease Risk in Dogs | PDF",1790644843]