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This study examined sex differences in CVD risk among Chinese adults aged 50+ with HIV using hospitalized data from Shenzhen between 2017 and 2022. Ten-year CVD risk was estimated via Pooled Cohort Equations, with logistic regression, marginal analyses, and segmented regression. High CVD risk affected 37.2% overall and was markedly higher in males than females, with age-specific inflection points. Findings link high risk to low CD4 counts and support earlier monitoring and sex-aware prevention.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sex-differences-in-cardiovascular-disease-risk-among-chinese-older-adults-living-with-hiv/426970/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sex-differences-in-cardiovascular-disease-risk-among-chinese-older-adults-living-with-hiv/426970.png","ImageObject",300,407,{"name":92,"@type":93},"LangkahRina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What gap does the study address regarding HIV and cardiovascular disease?","Question",{"text":112,"@type":113},"Although people living with HIV face higher CVD risk, sex differences in that risk have been unclear. The study directly investigates those differences among Chinese older adults with HIV.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was 10-year cardiovascular disease risk estimated?",{"text":117,"@type":113},"Ten-year CVD risk was estimated using the Pooled Cohort Equations.",{"name":119,"@type":110,"acceptedAnswer":120},"What main sex pattern did the study find in CVD risk?",{"text":121,"@type":113},"High CVD risk prevalence and average CVD risk were significantly higher in males than females, with males showing an increase after age 50 and females showing a later breakpoint around age 65.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426970,1790790816,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},962090893776,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","472 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.1612  \nSEX DIFFERENCES IN CARDIOVASCULAR DISEASE  \nRISK AMONG CHINESE OLDER ADULTS LIVING  \nWITH HIV  \nJunwen Yu1, Bei Wu2, Xiang Qi3, Lu Shao4, Ting Xu5, Hongzhou Lu6, and Zheng Zhu1, 1. Fudan University, Shanghai, Shanghai, China (People’s Republic), 2. NYU  \nShanghai, Shanghai, China (People’s Republic), 3. New York University, New York, New York, United States, 4. University of Hong Kong, Guangzhou, Guangdong, China (People’s Republic), 5. Nanjing Medical University, Nanjing, Jiangsu, China (People’s Republic), 6. The Third People’s Hospital of Shenzhen, Shenzhen, Guangdong, China (People’s Republic)  \nPeople living with HIV have twice the risk of developing cardiovascular disease (CVD) compared to HIV-negative individuals, yet sex differences remains unclear. This study aimed to address this gap by examining sex differences in CVD risk among Chinese older adults living with HIV. We analyzed data from hospitalized HIV-infected individuals aged 50 years or older ata major hospital in Shenzhen, China, from 2017 to 2022. The 10-year CVD risk was estimated using the Pooled Cohort Equations. Logistic regression and marginal analyses were performed, and a segmented regression model was used to analyze the relationship between high CVD risk prevalence and age, grouped into 5-year intervals. Among the 576 participants, 214 (37.2%) had high CVD risk (9.6% in females and 43.9% in males). The average CVD risk was significantly higher in males than females (8.79% vs. 3.58%, P \u003C 0.001) . High CVD risk was significantly associated with CD4 counts \u003C 200 cells/μL (OR = 1.832, 95% CI = 1.101-3.050, P = 0.020) . The predicted probability of low CD4 counts was higher in males (46.8%) than females (35.5%, P = 0.016) . The prevalence of high CVD risk increased significantly in males after age 50, whereas in females, the breakpoint occurred at age 65. Males exhibited a significantly higher CVD risk, emphasizing the need for early monitoring from a younger age. Although females demonstrated a later onset of high CVD risk, menopause-related lipid metabolism changes highlight the need of early prevention and integrating female-specific factors into risk assessment tools. Future research should further investigate the underlying mechanisms to improve precise prevention strategies.","cbCaidM0Oa4SQ3gV","https://ap.wps.com/l/cbCaidM0Oa4SQ3gV","pdf",453314,"English","# Abstract","[{\"question\":\"What gap does the study address regarding HIV and cardiovascular disease?\",\"answer\":\"Although people living with HIV face higher CVD risk, sex differences in that risk have been unclear. The study directly investigates those differences among Chinese older adults with HIV.\"},{\"question\":\"How was 10-year cardiovascular disease risk estimated?\",\"answer\":\"Ten-year CVD risk was estimated using the Pooled Cohort Equations.\"},{\"question\":\"What main sex pattern did the study find in CVD risk?\",\"answer\":\"High CVD risk prevalence and average CVD risk were significantly higher in males than females, with males showing an increase after age 50 and females showing a later breakpoint around age 65.\"}]","SEX DIFFERENCES IN CARDIOVASCULAR DISEASE RISK AMONG CHINESE OLDER ADULTS LIVING WITH HIV | PDF",1790642371]