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This randomized, double-blind, crossover trial tested whether 7 days of piceatannol supplementation (10 mg/day) changes endothelial function during rest and after low-intensity aerobic cycling. Blood pressure and brachial artery flow-mediated dilation were assessed before and after exercise. No improvements were found versus placebo.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/seven-day-supplementation-with-piceatannol-does-not-improve-endothelial-function-at-rest-or-after-exercise-a-pilot-study/459900/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/seven-day-supplementation-with-piceatannol-does-not-improve-endothelial-function-at-rest-or-after-exercise-a-pilot-study/459900.png","ImageObject",300,407,{"name":92,"@type":93},"Stanford","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the purpose of this study?","Question",{"text":112,"@type":113},"To determine whether 7-day piceatannol supplementation alters endothelial function at rest and after low-intensity aerobic exercise in humans.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the study designed and what did participants receive?",{"text":117,"@type":113},"Eight young, healthy men completed a randomized, double-blind, crossover trial with placebo and piceatannol (10 mg/day) for seven consecutive days.",{"name":119,"@type":110,"acceptedAnswer":120},"What outcomes were measured to evaluate endothelial function?",{"text":121,"@type":113},"Blood pressure and brachial artery flow-mediated dilation (FMD) were measured before and after 60 minutes of cycling at 30% of maximal oxygen uptake.",{"name":123,"@type":110,"acceptedAnswer":124},"Did piceatannol improve endothelial function compared with placebo?",{"text":125,"@type":113},"No. There were no between-trial differences in blood pressure or FMD at rest or after exercise, and the observed effects were small.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},459900,1791429514,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148,"preview_page_count":4},2336477552062,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","OPEN ACCESS  \n[https://doi.org/10.20463/pan.2025.0034](https://doi.org/10.20463/pan.2025.0034)  \n2025;29(4):048-056  \nReceived: 2025/09/22, Revised: 2025/10/29, Accepted: 2025/11/05, Published: 2025/12/30  \n©2025 Nobukazu Kasai et al. ; License Physical Activity and Nutrition. This is an open access article distributed under the terms of the creative commons attribution license ([https://creativecommons.org/l](https://creativecommons.org/l)icenses/by-nc/2 .0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \n*Corresponding author : Takuma Morishima, Ph.D.  \nFaculty of Liberal Arts and Sciences, Chukyo University, 101-2, Yagoto-honmachi, Showa, Nagoya, Aichi, 466- 8666, Japan  \nTel: +81-565-46-6629  \nE-mail: [t-morishima@lets.chukyo-u.ac.jp](t-morishima@lets.chukyo-u.ac.jp)  \n©2025 The Korean Society for Exercise Nutrition  \n[Purpose] Piceatannol, a polyphenolic compound found in high concentrations in passion fruit, has been reported to exert multiple physiological effects in preclinical studies, including vascular relaxation and increased expression of endothelial nitric oxide synthase. Despite these findings, its influence on endothelial function in humans, both at rest and in response to exercise, remains largely unknown. Therefore, this study aimed to investigate whether a 7-day regimen of piceatannol supplementation alters endothelial function at rest and following low-intensity aerobic exercise.  \n[Methods] Eight young, healthy men participated in a randomized, double-blind, crossover trial. Each participant completed two experimental conditions: (1) a placebo trial and (2) a piceatannol trial. For seven consecutive days, they ingested tablets containing either 0 mg (placebo) or 10 mg of piceatannol daily. On the morning of the eighth day (8:00 am), they visited the laboratory for baseline assessments, followed by 60 minutes of cycling exercise at 30% of their maximal oxygen uptake. Blood pressure and brachial artery flow-mediated dilation (FMD) were measured before and after exercise.  \n[Results] No between-trial differences were observed in blood pressure at rest, during exercise, or after exercise. %FMD and absolute FMD likewise did not differ between the placebo and piceatannol trials. The observed effects were small (partial η² ≈ 0.05-0.06), and analysis of covariance adjusting for baseline diameter or shear rate area under the curve yielded consistent results.  \n[Conclusion] Seven-day piceatannol supplementation did not enhance endothelial function at rest or after low-intensity aerobic exercise in young, healthy men.  \n[Keywords] piceatannol, supplementation, endothelial function, low-intensity exercise, flow-mediated dilation, aerobic exercise  \nSeven-day supplementation with piceatannol does not improve endothelial function at rest or after exercise: a pilot study  \nNobukazu Kasai1 / Kanon Hayashi1 / Masaki Kito2 / Takuma Morishima3*  \n1. Faculty of Health and Medical Sciences, Aichi Shukutoku University, Aichi, Japan  \n2. School of Engineering, Chukyo University, Aichi, Japan  \n3. Faculty of Liberal Arts and Sciences, Chukyo University, Aichi, Japan  \nINTRODUCTION  \nCardiovascular disease has become increasingly prevalent and is primarily driven by lifestyle factors1-3. Focusing on vascular endothelial function is essential for the prevention of cardiovascular diseases. Among the early indicators of cardiovascular disease development, endothelial dysfunction is recognized as a key vascular abnormality and a predictor of atherosclerosis onset4,5 . It is strongly associated with the risk of cardiovascular diseases4,5 . Polyphenols have been widely studied for their potential health benefits and as a nutritional strategy for the prevention of cardiovascular disease, particularly because they protect cells from oxidative stress6. Evidence suggests that polyphenols can positively affect energy metabolism, which promotes longevity and overa","cbCaieqlurnCIKQ3","https://ap.wps.com/l/cbCaieqlurnCIKQ3","pdf",1051580,"English","# Introduction\n# Purpose\n# Methods\n# Results\n# Conclusion\n# Keywords","[{\"question\":\"What was the purpose of this study?\",\"answer\":\"To determine whether 7-day piceatannol supplementation alters endothelial function at rest and after low-intensity aerobic exercise in humans.\"},{\"question\":\"How was the study designed and what did participants receive?\",\"answer\":\"Eight young, healthy men completed a randomized, double-blind, crossover trial with placebo and piceatannol (10 mg/day) for seven consecutive days.\"},{\"question\":\"What outcomes were measured to evaluate endothelial function?\",\"answer\":\"Blood pressure and brachial artery flow-mediated dilation (FMD) were measured before and after 60 minutes of cycling at 30% of maximal oxygen uptake.\"},{\"question\":\"Did piceatannol improve endothelial function compared with placebo?\",\"answer\":\"No. There were no between-trial differences in blood pressure or FMD at rest or after exercise, and the observed effects were small.\"}]","Seven-day supplementation with piceatannol does not improve endothelial function at rest or after exercise - a pilot study | PDF",1790757221,23]