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AIM: To investigate the relevance and dose-responsive relationship between UHR and 10-year CVD risk among Asian MASLD patients. METHODS: In this retrospective analysis, 3901 MASLD patients were enrolled and analyzed by risk-score stratification, logistic regression, and restricted cubic splines. RESULTS: Elevated UHR related to higher intermediate-to-high CVD risk; UHR also showed superior discrimination over conventional biomarkers, with an AUC of 0.655.",{"@graph":69,"@context":127},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/serum-uric-acid-to-high-density-lipoprotein-cholesterol-ratio-and-cardiovascular-risk-in-asian-patients-with-metabolic-dysfunction-associated-steatotic-liver-disease/406449/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/serum-uric-acid-to-high-density-lipoprotein-cholesterol-ratio-and-cardiovascular-risk-in-asian-patients-with-metabolic-dysfunction-associated-steatotic-liver-disease/406449.png","ImageObject",300,407,{"name":92,"@type":93},"Pentious","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119,123],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study aim regarding UHR and cardiovascular risk?","Question",{"text":113,"@type":114},"To determine how serum uric acid-to-HDL cholesterol ratio (UHR) relates to and shows dose-response with 10-year cardiovascular disease risk in Asian patients with MASLD.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were participants and CVD risk assessed?",{"text":118,"@type":114},"A retrospective cohort of 3901 MASLD patients was stratified by 10-year CVD risk using the Framingham risk score.",{"name":120,"@type":111,"acceptedAnswer":121},"Did UHR predict cardiovascular risk better than conventional biomarkers?",{"text":122,"@type":114},"Yes. Receiver operating characteristic analysis showed UHR outperformed individual biomarkers, with an AUC of 0.655 (95% CI: 0.635-0.674).",{"name":124,"@type":111,"acceptedAnswer":125},"Which subgroups showed the strongest association between UHR and CVD risk?",{"text":126,"@type":114},"The association was more pronounced in younger individuals (\u003C50 years), males, and those with central obesity, while it was attenuated in older adults (≥50 years) and females.","https://schema.org",{"og:url":83,"og:type":129,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":131,"canonical":83},"index,follow",{"doc_id":133,"site_id":62},406449,1790678655,{"code":4,"msg":5,"data":136},{"doc_id":133,"user_id":137,"nickname":92,"user_avatar":138,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":144,"language":145,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":146,"faqs":147,"seo_title":148,"seo_description":67,"update_tm":149,"read_time":150,"preview_page_count":4},1374404730887,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2025 December 28; 31(48): 112972  \nDOI: 10.3748/wjg.v31.i48.112972 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nORIGINAL ARTICLE  \nRetrospective Study  \nSerum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunctionassociated steatotic liver disease  \nYang Wang, Guang-Hui Ma, Ming-Yue Qu, Qi-Shui Xu, Hai-Xia Huang  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade B  \nNovelty: Grade B, Grade B  \nCreativity or Innovation: Grade B, Grade B  \nScientific Significance: Grade B, Grade B  \nP-Reviewer: Mburu SN, PhD, Kenya; Özlek B, MD, Associate Professor, Türkiye  \nReceived: August 12, 2025  \nRevised: September 16, 2025  \nAccepted: November 12, 2025  \nPublished online: December 28, 2025  \nProcessing time: 137 Days and 18.5 Hours  \nYang Wang, Department of Radiology, Affiliated Hospital of Jiangnan University, Wuxi 214100, Jiangsu Province, China  \nGuang-Hui Ma, Ming-Yue Qu, Hai-Xia Huang, Department of Radiology, Shanghai Health and Medical Center, Wuxi 214065, Jiangsu Province, China  \nQi-Shui Xu, Department of Anesthesiology, Wuxi No. 2 Chinese Medicine Hospital, Wuxi 214121, Jiangsu Province, China  \nCo-first authors: Yang Wang and Guang-Hui Ma.  \nCo-corresponding authors: Qi-Shui Xu and Hai-Xia Huang.  \nCorresponding author: Qi-Shui Xu, Department of Anesthesiology, Wuxi No. 2 Chinese Medicine Hospital, No. 390 Xincheng Road, Taihu Sub-district, Binhu District, Wuxi 214121, Jiangsu Province, [China.](China. 810204666@qq.com)[ 810204666@qq.com](China. 810204666@qq.com)  \nAbstract  \nBACKGROUND  \nThe association between the serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR) and cardiovascular disease (CVD) risk in Asian populations with metabolic dysfunction-associated steatotic liver disease (MASLD) remains insufficiently elucidated.  \nAIM  \nTo investigate the relevance and dose-responsive relationship between UHR and 10-year CVD risk among Asian MASLD patients.  \nMETHODS  \nIn this retrospective analysis, 3901 MASLD patients were enrolled based on established screening criteria. As measured by the Framingham risk score, participants were stratified according to their 10-year CVD risk. The association between UHR and CVD risk was evaluated using binary logistic regression, while dose-response patterns were explored through restricted cubic spline (RCS) modeling. The discriminatory capability of UHR, in comparison with conventional biomarkers, was further examined by receiver operating characteristic  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 28, 2025  Volume 31  Issue 48   \nWang Y et al. UHR stratifies CVD risk in Asian MASLD  \ncurve analysis.  \nRESULTS  \nMultivariable-adjusted analyses revealed that elevated UHR levels were significantly associated with an increased likelihood of intermediate-to-high CVD risk. RCS modeling demonstrated a linear dose-response relationship between UHR and the Framingham risk score (P for nonlinearity = 0.114) . Sex-stratified RCS analyses further indicated that this linear association persisted among males (P for nonlinearity = 0.167) but was not statistically significant in females (P for nonlinearity = 0.476) . Further stratified analyses revealed that the association was particularly pronounced among younger individuals (\u003C 50 years), males, and those with central obesity, whereas it was attenuated in older adults (≥ 50 years) and females. Receiver operating characteristic analysis demonstrated that UHR outperformed individual biomarkers in predicting 10-year CVD risk, showing an area under the curve of 0.655 (95% confidenc","cbCais7ySdsAw42M","https://ap.wps.com/l/cbCais7ySdsAw42M","pdf",2482649,11,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Core Tip\n# Citation","[{\"question\":\"What was the study aim regarding UHR and cardiovascular risk?\",\"answer\":\"To determine how serum uric acid-to-HDL cholesterol ratio (UHR) relates to and shows dose-response with 10-year cardiovascular disease risk in Asian patients with MASLD.\"},{\"question\":\"How were participants and CVD risk assessed?\",\"answer\":\"A retrospective cohort of 3901 MASLD patients was stratified by 10-year CVD risk using the Framingham risk score.\"},{\"question\":\"Did UHR predict cardiovascular risk better than conventional biomarkers?\",\"answer\":\"Yes. Receiver operating characteristic analysis showed UHR outperformed individual biomarkers, with an AUC of 0.655 (95% CI: 0.635-0.674).\"},{\"question\":\"Which subgroups showed the strongest association between UHR and CVD risk?\",\"answer\":\"The association was more pronounced in younger individuals (\\u003c50 years), males, and those with central obesity, while it was attenuated in older adults (≥50 years) and females.\"}]","Serum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunction-associated steatotic liver disease | PDF",1790565735,28]