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Protein array screening identified KIAA0513 as an antigen recognized by serum IgG in atherosclerosis, with higher anti-KIAA0513 antibody levels measured by amplified luminescence proximity homogeneous assay-linked immunosorbent assay across multiple conditions. ROC analysis highlighted strongest performance for esophageal cancer, nephrosclerosis-type CKD, and DM.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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is the study’s main focus regarding KIAA0513 antibodies?","Question",{"text":63,"@type":64},"The study evaluates whether serum IgG antibodies against KIAA0513 can serve as a common biomarker shared by atherosclerosis-related diseases and cancers.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was KIAA0513 initially identified in the patients?",{"text":68,"@type":64},"Initial screening used the protein array method to identify KIAA0513 as an antigen recognized by serum IgG antibodies in patients with atherosclerosis.",{"name":70,"@type":61,"acceptedAnswer":71},"Which conditions showed the highest ROC performance for anti-KIAA0513 antibodies?",{"text":72,"@type":64},"The highest areas under the ROC curves were obtained for esophageal cancer, nephrosclerosis-type chronic kidney disease, and diabetes mellitus.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},328316,1790159060,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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for mortal atherosclerotic and cancerous diseases  \nTAKAKI HIWASA 1‑3 , YOICHI YOSHIDA 1 , MASAAKI KUBOTA 1 , SHU‑YANG LI 1,2,4 , BO‑SHI ZHANG 1,2 , TOMOO MATSUTANI 1 , SEIICHIRO MINE 1,5,6 , TOSHIO MACHIDA 1,6,7 , MASAAKI ITO8 , SATOSHI YAJIMA8 , MIKAKO SHIROUZU9 , SHIGEYUKI YOKOYAMA 10 , MIZUKI SATA 11,12 , KAZUMASA YAMAGISHI 11 , HIROYASU ISO 13 , NORIE SAWADA 14 , SHOICHIRO TSUGANE 14 , MINORU TAKEMOTO 15,16 , AIKO HAYASHI 15 , KOUTARO YOKOTE 15 , YOSHIO KOBAYASHI 17 , KAZUYUKI MATSUSHITA 18 , KOICHIRO TATSUMI 19 , HIROTAKA TAKIZAWA20 , GO TOMIYOSHI21 , HIDEAKI SHIMADA3,8 and YOSHINORI HIGUCHI 1  \n1  \nDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan;  \nDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan;  \n2  \n3  \nDepartment of Clinical Oncology, Toho University Graduate School of Medicine, Tokyo 143‑8541, Japan; 4Department of Rehabilitation in Traditional Chinese Medicine, The Second Affiliated Hospital of  \n5  \nZhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China; Department of Neurological Surgery, Chiba Prefectural Sawara Hospital, Chiba 287‑0003, Japan; 6Department of Neurological Surgery, Chiba Cerebral and Cardiovascular Center, Chiba 290‑0512, Japan; 7Department of Neurosurgery, Eastern Chiba Medical Center, Chiba 283‑8686, Japan; 8Department of Gastroenterological Surgery and Clinical Oncology, Toho University Graduate School of Medicine, Tokyo 143‑8541, Japan; 9Laboratory for Protein Functional and Structural Biology,  \n10  \nRIKEN Center for Biosystems Dynamics Research, Yokohama, Kanagawa 230‑0045, Japan; RIKEN Structural Biology Laboratory, Yokohama, Kanagawa 230‑0045, Japan; 11Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba 305‑8575, Japan; 12Department of Preventive Medicine and Public Health, Keio University School of Medicine,  \n13  \nTokyo 160‑8582, Japan; Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan; 14Epidemiology and Prevention Group, Center for Public Health Sciences,  \n15  \nNational Cancer Center, Tokyo 104‑0045, Japan; Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan; 16Department of Diabetes, Metabolism and Endocrinology, School of Medicine, International University of Health and Welfare, Chiba 286‑8686, Japan;  \nDepartment of Cardiovascular Medicine, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan;  \n17  \n18  \nDepartment of Laboratory Medicine & Division of Clinical Genetics, Chiba University Hospital, Chiba 260‑8677, Japan;  \n19Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan;  \n20  \nPort Square Kashiwado Clinic, Kashiwado Memorial Foundation, Chiba 260‑0025, Japan; 21  \nMedical Project Division, Research Development Center, Fujikura Kasei Co., Saitama 340‑0203, Japan  \nReceived March 13, 2024; Accepted June 5, 2024  \nDOI: 10. 3892/mi.2024.169  \nCorrespondence to: Dr Takaki Hiwasa, Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Inohana 1‑8‑1, Chuo‑ku, Chiba 260‑8670, Japan  \nE‑mail: hiwasa_takaki@faculty.chiba‑[u.jp](u.jp)  \nAbbreviations: 95% CI, 95% confidence interval; AIS, acute ischemic stroke; AMI, acute myocardial infarction; AlphaLISA, amplified luminescence proximity homogeneous assay‑linked immunosorbent assay; Asympt‑CI, asymptomatic ischemic stroke; AUC, areas under the ROC curve; BC, breast cancer; BMI, body mass index; CAVI, cardio‑ankle vascular index; cCI, chronic‑phase  \ncerebral infarction; CKD, chronic kidney disease; CRC, colorectal cancer; CRP, C‑reactive protein; CVD, cardiovascular disease; DM, diabetes mel","cbCaiqlsOUWc1TTJ","https://ap.wps.com/l/cbCaiqlsOUWc1TTJ","pdf",5330418,14,"English","# Abstract\n## Antibody biomarker background\n## KIAA0513 antigen identification\n## Serum antibody validation across diseases\n## ROC performance and key clinical associations","[{\"question\":\"What is the study’s main focus regarding KIAA0513 antibodies?\",\"answer\":\"The study evaluates whether serum IgG antibodies against KIAA0513 can serve as a common biomarker shared by atherosclerosis-related diseases and cancers.\"},{\"question\":\"How was KIAA0513 initially identified in the patients?\",\"answer\":\"Initial screening used the protein array method to identify KIAA0513 as an antigen recognized by serum IgG antibodies in patients with atherosclerosis.\"},{\"question\":\"Which conditions showed the highest ROC performance for anti-KIAA0513 antibodies?\",\"answer\":\"The highest areas under the ROC curves were obtained for esophageal cancer, nephrosclerosis-type chronic kidney disease, and diabetes mellitus.\"}]","Serum anti‑KIAA0513 antibody as a common biomarker for mortal atherosclerotic and cancerous diseases | PDF",1789979311,35]