[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-333010-105":59,"doc-detail-333010-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","serum-and-salivary-levels-of-phosphate-in-gastric-and-colorectal-cancer-patients","Serum and Salivary Levels of Phosphate in Gastric and Colorectal Cancer Patients","","Objective: Gastrointestinal cancer is among the most common causes of death worldwide, and lack of early clinical symptoms often delays diagnosis and increases disease stage. This study assessed phosphate concentration in saliva and serum for patients with gastric and colorectal cancer, compared with healthy controls, motivated by phosphate’s role in cell division and the potential diagnostic value of saliva. Methods: Pathologically confirmed patients and healthy participants provided morning saliva and serum for photometric phosphate measurement. Results: Serum and stimulated/unstimulated salivary phosphate were significantly lower in the patient group, with more reported dry mouth despite higher salivary flow. Conclusion: Lower serum and salivary phosphate levels characterize gastrointestinal malignant disease.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/serum-and-salivary-levels-of-phosphate-in-gastric-and-colorectal-cancer-patients/333010/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/serum-and-salivary-levels-of-phosphate-in-gastric-and-colorectal-cancer-patients/333010.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-11","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is early diagnosis important for gastrointestinal cancers in this study?","Question",{"text":113,"@type":114},"Early-stage gastrointestinal malignancies often lack typical symptoms, so diagnosis may be delayed and the stage increases. The study emphasizes that timely diagnosis is crucial.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were phosphate levels measured in serum and saliva?",{"text":118,"@type":114},"Morning saliva and serum samples were collected, and phosphate concentration was determined using a photometric method.",{"name":120,"@type":111,"acceptedAnswer":121},"What was the main finding regarding phosphate levels between patients and healthy controls?",{"text":122,"@type":114},"Patients with gastric or colorectal cancer had significantly lower serum phosphate and lower stimulated and unstimulated salivary phosphate than healthy individuals.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},333010,1790120239,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":52,"preview_page_count":4},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","Short Communications  \nEditorial Process: Submission:05/25/2024 Acceptance:12/07/2024  \nSerum and Salivary Levels of Phosphate in Gastric and Colorectal Cancer Patients  \nMohammad Hossein Hajali 1 , Hamidreza Karbalaei-Musa 1 , Mohammad Arbaghaei1, Mohsen Rajaeinejad2, Peyman Aslani3, Iraj Mirzaii-Dizgah4 *  \nAbstract  \nObjective: Gastrointestinal cancer is one of the most common causes of death worldwide. As there are no clinical symptoms at the beginning of the disease, the diagnosis can be delayed and the stage increased. Timely diagnosis is therefore crucial. Since one of the factors involved in cell division is phosphate, and considering the benefits of using saliva, this study investigated the phosphate concentration in saliva and serum in patients with gastric and colorectal cancer as well as in healthy patients. Methods: 26 patients with gastric and colorectal cancer confirmed by pathologic criteria were admitted to the oncology department of Imam Reza Hospital, and 30 healthy individuals participated in this study. Saliva and serum samples were collected in the morning. Phosphate concentration was determined using a photometric method. Results: The average phosphate content in serum as well as in stimulated and unstimulated saliva was significantly lower in the patient group. In addition, the results showed that the patients reported more dry mouth than the control group despite increased salivary flow. Conclusion: It appears that patients with malignant diseases of the gastrointestinal tract, such as colorectal cancer and gastric cancer, have lower serum and salivary phosphate levels than healthy individuals.  \nKeywords: Colorectal cancer-gastric cancer-phosphate-serum-saliva  \nAsian Pac J Cancer Prev, 25 (12), 4111-4114  \nIntroduction  \nGastrointestinal (GI) cancers are among the most common types of cancer, accounting for approximately 25 percent of cases and having significant death rates. The aging process and environmental factors may create mutations that lead to GI malignancies. In other words, Cell tumor genesis results from the interaction of genetic factors with physical, chemical, and biological factors [1] . Because early-stage GI malignancies do not exhibit typical symptoms, most patients are identified with severe regional lymph node involvement and/or invasion of neighboring tissues in the late stages of the illness. Therefore, early diagnosis is of vital importance for the diagnosis of GI malignancies. A biopsy is the gold diagnostic standard for most tumors, including GI cancers. However, this method has disadvantages such as invasiveness, the need for complex equipment, and incorrect sample evaluation due to the cancerous tissue’s different structure. Therefore, the identification and development of a rapid, cost-effective, and non-invasive screening method should be considered [2, 3] .  \nSaliva is a physiologic fluid with the mentioned characteristics that is released by three pairs of salivary glands: parotid, submandibular, and sublingual, or comes from the blood by passive transport [4, 5] . Reduced salivary output may be harmful to the patient since it helps with digestion, moisturizes the oral cavity, and makes speaking easier [6] . Saliva, on the other hand, includes substances such as proteins, antibodies, enzymes, hormones, and metabolites, all of which have been shown in recent research to have promise in the prognosis, diagnosis, and monitoring of patients suffering from various diseases, including cancer [2, 4] .  \nPhosphorus is an extracellular liquid cation that exists in the body in the form of phosphate due to its high reactivity with oxygen. Phosphate is essential for metabolic activities such as cell membrane formation, DNA and RNA molecules, energy metabolism, signal transmission, and pH regulation in the body [7] . Phosphate, like calcium, is regulated by vitamin D3 (vitD) and parathyroid hormone (PTH) and is mostly excreted through the kidneys. Phosphate imbalance is generally i","cbCainZJsRERreMY","https://ap.wps.com/l/cbCainZJsRERreMY","pdf",284540,"English","# Abstract\n## Objective, Methods, Results, Conclusion\n# Introduction\n## Gastrointestinal cancer and need for early diagnosis\n## Saliva as a diagnostic medium\n## Role of phosphate and endocrine regulation\n# Materials and Methods\n## Ethics approval and consent\n## Study design, participants, inclusion and exclusion","[{\"question\":\"Why is early diagnosis important for gastrointestinal cancers in this study?\",\"answer\":\"Early-stage gastrointestinal malignancies often lack typical symptoms, so diagnosis may be delayed and the stage increases. The study emphasizes that timely diagnosis is crucial.\"},{\"question\":\"How were phosphate levels measured in serum and saliva?\",\"answer\":\"Morning saliva and serum samples were collected, and phosphate concentration was determined using a photometric method.\"},{\"question\":\"What was the main finding regarding phosphate levels between patients and healthy controls?\",\"answer\":\"Patients with gastric or colorectal cancer had significantly lower serum phosphate and lower stimulated and unstimulated salivary phosphate than healthy individuals.\"}]","Serum and Salivary Levels of Phosphate in Gastric and Colorectal Cancer Patients | PDF",1790000339]