[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-412727-105":59,"doc-detail-412727-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","sensitivity-of-metastatic-mucinous-tailgut-cyst-adenocarcinoma-to-gemcitabine-and-radiation-a-case-report","Sensitivity of metastatic mucinous tailgut cyst adenocarcinoma to gemcitabine and radiation - a case report","","Metastatic mucinous adenocarcinoma arising from a tailgut cyst is an ultra-rare malignancy, with limited published evidence on chemosensitivity and radiosensitivity and treatment largely extrapolated from rectal cancer. This case report describes a patient achieving 1.5 years of clinical benefit from gemcitabine chosen via transcriptomic analysis of circulating tumor cells using an in vitro assay. Tumor recurrence and metastases demonstrated clear radiosensitivity, while molecular profiling showed microsatellite stability and KRAS p. G13D and TP53 p. C176W mutations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sensitivity-of-metastatic-mucinous-tailgut-cyst-adenocarcinoma-to-gemcitabine-and-radiation-a-case-report/412727/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sensitivity-of-metastatic-mucinous-tailgut-cyst-adenocarcinoma-to-gemcitabine-and-radiation-a-case-report/412727.png","ImageObject",300,407,{"name":92,"@type":93},"pop out","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is gemcitabine selected in this case?","Question",{"text":112,"@type":113},"Gemcitabine was selected after transcriptomic analysis of the patient’s circulating tumor cells using an in vitro chemosensitivity assay.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What evidence in the case supports radiosensitivity?",{"text":117,"@type":113},"Pelvic recurrence and osseous metastases showed clear radiosensitivity.",{"name":119,"@type":110,"acceptedAnswer":120},"Which molecular alterations were reported in the tumor profile?",{"text":121,"@type":113},"The tumor was microsatellite stable and carried KRAS p. G13D and TP53 p. C176W mutations.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},412727,1790909805,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962090760408,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","TYPE Case Report  \nPUBLISHED 18 December 2025 DOI 10.3389/fonc.2025.1621324  \nOPEN ACCESS  \nEDITED BY  \nDario Baratti,  \nFondazione IRCCS Istituto Nazionale Tumori, Italy  \nREVIEWED BY  \nFrancesco Fleres, AOU G Martino, Italy Peng Huang,  \nSichuan University, China  \n*CORRESPONDENCE  \nMaliha Nusrat  \n [nusratm@mskcc.org](nusratm@mskcc.org)  \n†PRESENT ADDRESS  \nCarla Hajj,  \nCleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates  \nRECEIVED 30 April 2025  \nACCEPTED 24 October 2025  \nPUBLISHED 18 December 2025  \nCITATION  \nNusrat M, Yu KH, Tang L, El Amine MA, McCarthy B, Ganesh K, de Stanchina E, Pappou E, Garcia-Aguilar J, Bartelstein M, Crane C, Kelsen D, Saltz L and  \nHajj C (2025) Sensitivity of metastatic mucinous tailgut cyst adenocarcinoma to gemcitabine and radiation: a case report.  \nFront. Oncol. 15:1621324 .  \ndoi: 10.3389/fonc.2025.1621324  \nCOPYRIGHT  \n© 2025 Nusrat, Yu, Tang, El Amine, McCarthy, Ganesh, de Stanchina, Pappou, Garcia-Aguilar, Bartelstein, Crane, Kelsen, Saltz and Hajj. This isan open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nSensitivity of metastatic mucinous tailgut cystadenocarcinoma to gemcitabine and radiation: a case report  \nMaliha Nusrat 1*, Kenneth H. Yu 1, Laura Tang 2,  \nMohammad Ali El Amine 3, Brian McCarthy 4, Karuna Ganesh 1, Elisa de Stanchina 5, Emmanouil Pappou 6, Julio Garcia-Aguilar 6, Meredith Bartelstein 6, Christopher Crane 7, David Kelsen 1, Leonard Saltz 1 and Carla Hajj 7†  \n1Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2 Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3 Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 4Adera Biolabs, Germantown, MD, United States, 5The Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 6 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 7 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States  \nMetastatic mucinous adenocarcinoma arising from a tailgut cyst is an ultra-rare cancer. Literature on the chemosensitivity and radiosensitivity of this cancer is lacking, and treatment is extrapolated from rectal cancer management. We are reporting, for the first time, the case of a patient with metastatic tailgut cystadenocarcinoma who derived 1.5 years of clinical benefit from treatment with gemcitabine, selected as a result of transcriptomic analysis of her circulating tumor cells using an in vitro assay. The cancer was refractory to regimens extrapolated from rectal cancer management (capecitabine with oxaliplatin, and irinotecan) . Pelvic recurrence and osseous metastases were clearly radiosensitive. Tumor molecular profile showed microsatellite stable cancer with KRAS p. G13D and TP53 p. C176W mutations.  \nKEYWORDS  \ntailgut cyst adenocarcinoma, retrorectal cyst hamartoma, circulating tumor cells, chemosensitivity assay, personalized medicine  \nIntroduction  \nTailgut cyst or retrorectal cyst hamartoma is a congenital remnant of the embryonic tailgut (1). The developing human embryo has a tail caudal to the cloaca (future anorectal canal), and a portion of the hindgut extends into this tail as the tailgut or post-anal gut (Supplementary Figure S1)(2). Failure of the tailgut to involute by the eighth week of gestation can result in cysts. True incidence is under-estimated, as many tailgut cysts are asymptomatic, and it is at","cbCaisXdYH2YClI1","https://ap.wps.com/l/cbCaisXdYH2YClI1","pdf",2584629,"English","# Introduction\n## Tailgut cysts and malignant transformation\n## Metastatic mucinous tailgut cyst adenocarcinoma\n# Case presentation","[{\"question\":\"Why is gemcitabine selected in this case?\",\"answer\":\"Gemcitabine was selected after transcriptomic analysis of the patient’s circulating tumor cells using an in vitro chemosensitivity assay.\"},{\"question\":\"What evidence in the case supports radiosensitivity?\",\"answer\":\"Pelvic recurrence and osseous metastases showed clear radiosensitivity.\"},{\"question\":\"Which molecular alterations were reported in the tumor profile?\",\"answer\":\"The tumor was microsatellite stable and carried KRAS p. G13D and TP53 p. C176W mutations.\"}]","Sensitivity of metastatic mucinous tailgut cyst adenocarcinoma to gemcitabine and radiation - a case report | PDF",1790592653,23]