[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-427453-105":59,"doc-detail-427453-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","sense-of-control-and-epigenetic-aging-the-mediating-role-of-lifestyle-behaviors","SENSE OF CONTROL AND EPIGENETIC AGING: THE MEDIATING ROLE OF LIFESTYLE BEHAVIORS","","Study examines how sense of control relates to epigenetic aging through lifestyle behaviors, including diet, exercise, sleep, alcohol consumption, and smoking history. Psychosocial factors such as purpose in life are linked to epigenetic aging, and lifestyle behaviors may mediate these relationships. Data come from two MIDUS sub-study samples: second (M2; n=1,255) and refresher (R1; n=863), analyzed with a mediation model using the PROCESS Macro in SPSS.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sense-of-control-and-epigenetic-aging-the-mediating-role-of-lifestyle-behaviors/427453/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sense-of-control-and-epigenetic-aging-the-mediating-role-of-lifestyle-behaviors/427453.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-19","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What did the study test about sense of control and epigenetic aging?","Question",{"text":112,"@type":113},"It tested whether sense of control is associated with epigenetic age and whether lifestyle behaviors mediate that relationship.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which lifestyle behaviors were included as mediators?",{"text":117,"@type":113},"Diet, exercise, sleep, alcohol consumption, and smoking history were evaluated as mediators.",{"name":119,"@type":110,"acceptedAnswer":120},"Which epigenetic clocks showed mediation effects?",{"text":121,"@type":113},"Relationships with three second-generation clocks (DunedinPACE, GrimAge, and PhenoAge) were fully mediated by lifestyle behaviors.",{"name":123,"@type":110,"acceptedAnswer":124},"Why might first-generation epigenetic clocks have shown no significant association?",{"text":125,"@type":113},"The abstract suggests their higher correlations with chronological age may have limited detectable effects for Hannum and Horvath clocks.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},427453,1790791832,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":81},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Innovation in Aging, 2025, Vol. 9, No. S2 707  \nAbstract citation ID: igaf122.2410  \nSENSE OF CONTROL AND EPIGENETIC AGING: THE MEDIATING ROLE OF LIFESTYLE BEHAVIORS  \nKylie Schiloski1, Sofia Christofi1, Eric Kim2, Steven Cole3, and Margie Lachman1, 1. Brandeis University, Waltham, Massachusetts, United States, 2. The University of British Columbia, Vancouver, British Columbia, Canada, 3. University of California, Los Angeles School of Medicine, Los Angeles, California, United States  \nPsychosocial factors such as purpose in life have been found to contribute to epigenetic aging and lifestyle behaviors may mediate these associations. Sense of control is another promising protective psychosocial factor that has been associated with greater engagement in protective lifestyle behaviors and better health. The present study tested whether sense of control was related to epigenetic age and whether lifestyle behaviors (diet, exercise, sleep, alcohol consumption, and smoking history) were a mediator. We predicted that individuals with a higher sense of control would engage in more protective lifestyle behaviors which would be related to a lower epigenetic age. Data were collected from two sub-study samples, the second (M2; n =1,255) and refresher (R1; n = 863) waves of the Midlife in the United States Study (MIDUS). We tested our hypothesis with a mediation model using the PROCESS Macro in SPSS. Results showed that the relationships between sense of control and three second-generation epigenetic clocks (DunedinPACE, GrimAge, and PhenoAge) were fully mediated by lifestyle behaviors, adjusting for chronological age, sex, education, race, and study sample. In this model, sense of control was not significantly related to two first-generation epigenetic clocks (Hannum or Horvath clocks), possibly due to their higher correlations with chronological age. Taken together, these findings suggest that sense of control is a promising modifiable psychosocial variable that could be used to promote engagement in protective lifestyle behaviors potentially slowing age-related declines.","cbCaitwOLcHOQHCe","https://ap.wps.com/l/cbCaitwOLcHOQHCe","pdf",642222,"English","# Abstract\n## Purpose and hypotheses\n## Methods and data sources\n## Analytical approach\n## Key findings\n## Implications","[{\"question\":\"What did the study test about sense of control and epigenetic aging?\",\"answer\":\"It tested whether sense of control is associated with epigenetic age and whether lifestyle behaviors mediate that relationship.\"},{\"question\":\"Which lifestyle behaviors were included as mediators?\",\"answer\":\"Diet, exercise, sleep, alcohol consumption, and smoking history were evaluated as mediators.\"},{\"question\":\"Which epigenetic clocks showed mediation effects?\",\"answer\":\"Relationships with three second-generation clocks (DunedinPACE, GrimAge, and PhenoAge) were fully mediated by lifestyle behaviors.\"},{\"question\":\"Why might first-generation epigenetic clocks have shown no significant association?\",\"answer\":\"The abstract suggests their higher correlations with chronological age may have limited detectable effects for Hannum and Horvath clocks.\"}]","SENSE OF CONTROL AND EPIGENETIC AGING: THE MEDIATING ROLE OF LIFESTYLE BEHAVIORS | PDF",1790643901]