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Yet, the specific pathways by which SHV alters sperm parameters and functional outcomes remain unclear. This retrospective analysis assessed SHV prevalence across a large semen-sample population and examined associations with semen quality, DNA damage, acrosome and mitochondria function, and seminal plasma composition.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/seminal-hyperviscosity-is-associated-with-poor-sperm-quality-and-function/543170/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/seminal-hyperviscosity-is-associated-with-poor-sperm-quality-and-function/543170.png","ImageObject",300,407,{"name":92,"@type":93},"Guten tag","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-21","2026-10-11",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the purpose of the study on seminal hyperviscosity (SHV)?","Question",{"text":112,"@type":113},"To clarify how SHV contributes to male infertility by impairing sperm movement and to evaluate mechanisms affecting sperm parameters and functions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What methods were used to evaluate SHV and its relationships to sperm outcomes?",{"text":117,"@type":113},"A retrospective study assessed SHV prevalence in a large population (55,733 semen samples) and analyzed links between SHV and semen quality, DNA damage, acrosome function, mitochondria function, and seminal plasma composition.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key findings regarding SHV severity and sperm quality or function?",{"text":121,"@type":113},"SHV occurred in 12.4% of samples, and severity correlated with worse semen parameters and impaired acrosomal function and lower mitochondrial membrane potential; severe SHV also showed higher HDS and chromatin condensation anomalies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},543170,1791786424,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},687212321768,"https://ap-avatar.wpscdn.com/avatar/a0010bdbe886d2fe77?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789897067658708522","Journal of Assisted Reproduction and Genetics (2025) 42:3967–3978  \n[https://doi.org/10.1007/s10815-025-03551-0](https://doi.org/10.1007/s10815-025-03551-0)  \nSeminal hyperviscosity is associated with poor sperm quality and function  \nJiao Qin1,2 · Qingyuan Cheng1,2 · Yingbi Wu1,2 · Siyu Long1,2 · Yuanyuan Zeng1,2 · Wenrui Zhao1,2 · Lin Yu1,2 · Fuping Li1,2  \nReceived: 17 April 2025 / Accepted: 4 June 2025 / Published online: 24 June 2025  \n© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025  \nAbstract  \nPurpose Male infertility affects many couples worldwide. Seminal hyperviscosity (SHV) is increasingly recognized as a contributor to male infertility by impairing sperm movement. However, the precise mechanisms by which SHV affects sperm parameters and functions remain unclear.  \nMethods This is a retrospective study. We evaluated the prevalence of subjects with SHV in a large population (including 55,733 semen samples) referring to the Department of Andrology, West China Second University Hospital, as well as the relationship between SHV and sperm quality, DNA damage, Acrosome function, mitochondria function, and seminal plasma composition.  \nResults SHV was identified in 12.4% of samples (mild: 7.7%, moderate: 4.1%, severe: 0.6%), with severity correlating to poorer semen parameters, including reduced volume, total sperm count, progressive motility (PR), viability, and normal morphology (all p \u003C 0.05). Notably, SHV samples exhibited impaired acrosomal function and lower mitochondrial membrane potential (all p \u003C 0.05), despite paradoxically lower DNA fragmentation indices (DFI) in mild/moderate cases. Severe SHV showed elevated high DNA stainability (HDS) and chromatin condensation anomalies (p \u003C 0.05) . Seminal plasma analysis revealed higher rates of abnormal fructose levels in SHV groups, suggesting seminal vesicle dysfunction as a potential etiology.  \nConclusion These findings highlight SHV’s multifaceted detrimental effects on sperm functionality beyond conventional motility metrics, emphasizing its clinical relevance in fertility assessments. All these results remind that clinicians should pay more attention to the index of semen viscosity. In addition, standardized viscosity evaluation protocols and targeted interventions for SHV-related glandular deficiencies are warranted to improve diagnostic accuracy and treatment outcomes.  \nKeyword Male infertility · Seminal hyperviscosity · Sperm quality · Sperm function  \n* Lin Yu[yulin2005@scu.edu.cn](yulin2005@scu.edu.cn)  \n* Fuping Li[lfpsnake@scu.edu.cn](lfpsnake@scu.edu.cn)  \nJiao Qin  \n[qinjiao@scu.edu.cn](qinjiao@scu.edu.cn)[ ](qinjiao@scu.edu.cn)Qingyuan Cheng [791430418@qq.com](791430418@qq.com)[ ](791430418@qq.com)Yingbi Wu [403582169@qq.com](403582169@qq.com)[ ](403582169@qq.com)Siyu Long[siyulong0109@163.com](siyulong0109@163.com)  \nYuanyuan Zeng  \n[zengyuanyuan000@163.com](zengyuanyuan000@163.com)  \nWenrui Zhao  \n[376955730@qq.com](376955730@qq.com)  \n1 Department of Andrology/Sichuan Human Sperm Bank, West China Second University Hospital, Sichuan University, 1416 Chenglong Avenue, Jinjiang District, Chengdu, Sichuan, China  \n2 Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education, Chengdu, China  \nIntroduction  \nMale infertility is a significant health issue affecting many couples worldwide, contributing to fertility problems in approximately 30–40% of subfertile couples and being the sole contributor in 20% of infertile couples [1 , 2] . Several causes of male factor infertility have been identified, including oxidative stress and reactive oxygen species, varicocele, leukocytospermia, infection, inflammation, dysfunction of the male sex glands, and unexplained infertility [3–6] . These intrinsic causes lead to a decrease in semen parameters (such as decreased sperm volume, concentration, motility, viability, and normal morphology, along wit","cbCain08iDppaL24","https://ap.wps.com/l/cbCain08iDppaL24","pdf",1415953,12,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the purpose of the study on seminal hyperviscosity (SHV)?\",\"answer\":\"To clarify how SHV contributes to male infertility by impairing sperm movement and to evaluate mechanisms affecting sperm parameters and functions.\"},{\"question\":\"What methods were used to evaluate SHV and its relationships to sperm outcomes?\",\"answer\":\"A retrospective study assessed SHV prevalence in a large population (55,733 semen samples) and analyzed links between SHV and semen quality, DNA damage, acrosome function, mitochondria function, and seminal plasma composition.\"},{\"question\":\"What were the key findings regarding SHV severity and sperm quality or function?\",\"answer\":\"SHV occurred in 12.4% of samples, and severity correlated with worse semen parameters and impaired acrosomal function and lower mitochondrial membrane potential; severe SHV also showed higher HDS and chromatin condensation anomalies.\"}]","Seminal hyperviscosity is associated with poor sperm quality and function | PDF",1791758050]