[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31425":3,"doc-seo-31425":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31425,1099513958762,"Logic","https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?_k=1776737595927829259",8,"Research & Report","Self-Generative Singlet Oxygen (1O2)-Initiated Chemical Modification of Nuclear DNAs Combats Tumor Drug Resistance","Multidrug resistance (MDR) undermines chemotherapy by limiting drug action and promoting efficient detoxification and damage repair. A self-generative singlet oxygen (1O2)-initiated chemical modification of nuclear DNAs (SiCMoND) strategy synergizes with chemotherapy to disable MDR tumor cells. Tumor-targeted nano-bombs (FA(CT-fT-Dox)) release Cu-TCPP and fTAT-Dox under tumor microenvironment disassembly; Cu-TCPP converts H2O2 to 1O2 and triggers covalent cyclization with DNA nucleobases, causing severe DNA damage and restoring therapeutic susceptibility. Sustained intranuclear Dox release suppresses transcription/translation and drives apoptosis. In vivo, FA(CT-fT-Dox) outperforms a DNA-modification–free counterpart with 83.3% tumor suppression in MCF-7/ADR tumors.","cbCaitSmg6p8wqZ1","https://ap.wps.com/l/cbCaitSmg6p8wqZ1","pdf",3596615,1,14,"English","en","# Abstract\n# Introduction\n## Multidrug resistance challenges in chemotherapy\n## Existing strategies to overcome MDR\n## Limitations of gene interference and targeted nanodrugs\n# Scheme and Figures overview\n## SiCMoND approach schematic\n## 1O2 generation and nanoparticle characterization\n## Cellular retention and molecular mechanism readouts","[{\"question\":\"What is the core idea of the SiCMoND approach described in the document?\",\"answer\":\"The approach uses self-generative singlet oxygen (1O2) to initiate covalent chemical modification of nuclear DNAs, thereby amplifying DNA damage and increasing tumor susceptibility to chemotherapy.\"},{\"question\":\"How are Cu-TCPP and fTAT-Dox delivered to the tumor and released?\",\"answer\":\"Tumor-targeted FA(CT-fT-Dox) nanoparticles accumulate at the tumor site and undergo disassembly in the tumor microenvironment, releasing Cu-TCPP and fTAT-Dox simultaneously.\"},{\"question\":\"What outcome is reported for the multidrug-resistant MCF-7/ADR tumor model?\",\"answer\":\"In vivo results show FA(CT-fT-Dox) achieves stronger antitumor efficacy than the DNA-modification–free control, with 83.3% tumor suppression and a 1.6-fold improvement in efficacy.\"}]",1779483627,35,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"self-generative-singlet-oxygen-1o2-initiated-chemical-modification-of-nuclear-dnas-combats-tumor-drug-resistance","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/self-generative-singlet-oxygen-1o2-initiated-chemical-modification-of-nuclear-dnas-combats-tumor-drug-resistance/31425/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-22",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What is the core idea of the SiCMoND approach described in the document?","Question",{"text":73,"@type":74},"The approach uses self-generative singlet oxygen (1O2) to initiate covalent chemical modification of nuclear DNAs, thereby amplifying DNA damage and increasing tumor susceptibility to chemotherapy.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How are Cu-TCPP and fTAT-Dox delivered to the tumor and released?",{"text":78,"@type":74},"Tumor-targeted FA(CT-fT-Dox) nanoparticles accumulate at the tumor site and undergo disassembly in the tumor microenvironment, releasing Cu-TCPP and fTAT-Dox simultaneously.",{"name":80,"@type":71,"acceptedAnswer":81},"What outcome is reported for the multidrug-resistant MCF-7/ADR tumor model?",{"text":82,"@type":74},"In vivo results show FA(CT-fT-Dox) achieves stronger antitumor efficacy than the DNA-modification–free control, with 83.3% tumor suppression and a 1.6-fold improvement in efficacy.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]