[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31348":3,"doc-seo-31348":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31348,687197207919,"Theodora","https://ap-avatar.wpscdn.com/avatar/a000253d6f5f7c60be?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779446848396160552",7,"Healthcare","Selective Autophagy in Kidney Disease","Kidney function depends on tightly regulated organelle turnover to preserve cellular homeostasis and meet high energetic demand. Autophagy comprises selective, cargo-specific pathways, including mitophagy, lipophagy and ER-phagy, which form coordinated networks coupling stress- and nutrient-sensing regulators with core autophagy machinery and lysosomal capacity. Selective autophagy supports renal stress adaptation, repair, and disease progression; inadequate, excessive, or mistimed autophagic flux contributes to tubular injury, immune remodelling and fibrosis. Emerging selective pathways such as lysophagy, Golgiphagy and nucleophagy may further shape renal responses. Renal therapy requires precisely timed, cell-specific modulation guided by biomarkers.","cbCairqMOpuTkzCg","https://ap.wps.com/l/cbCairqMOpuTkzCg","pdf",3316682,1,16,"English","en","# Introduction\n## Selective autophagy in kidney disease\n# Sensing, decision-making and execution of selective autophagy","[{\"question\":\"What makes autophagy in the kidney “selective” rather than non-specific?\",\"answer\":\"The review describes specialized cargo-specific pathways that target particular organelles, such as mitophagy, lipophagy, and ER-phagy, rather than relying only on non-selective degradation.\"},{\"question\":\"How does selective autophagy affect kidney injury and chronic progression?\",\"answer\":\"Selective autophagy helps preserve organelle homeostasis during acute kidney injury, transition toward chronic kidney disease, and diabetic kidney disease, whereas insufficient, excessive, or mistimed autophagic flux drives tubular injury, immune remodelling, and fibrosis.\"},{\"question\":\"Which renal therapeutic considerations are highlighted for targeting selective autophagy?\",\"answer\":\"Effective strategies require carefully timed and precise cell-specific modulation and biomarker-guided patient stratification to improve efficacy and avoid adverse effects.\"}]",1779310983,40,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"selective-autophagy-in-kidney-disease","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/healthcare/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/selective-autophagy-in-kidney-disease/31348/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-20",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What makes autophagy in the kidney “selective” rather than non-specific?","Question",{"text":73,"@type":74},"The review describes specialized cargo-specific pathways that target particular organelles, such as mitophagy, lipophagy, and ER-phagy, rather than relying only on non-selective degradation.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How does selective autophagy affect kidney injury and chronic progression?",{"text":78,"@type":74},"Selective autophagy helps preserve organelle homeostasis during acute kidney injury, transition toward chronic kidney disease, and diabetic kidney disease, whereas insufficient, excessive, or mistimed autophagic flux drives tubular injury, immune remodelling, and fibrosis.",{"name":80,"@type":71,"acceptedAnswer":81},"Which renal therapeutic considerations are highlighted for targeting selective autophagy?",{"text":82,"@type":74},"Effective strategies require carefully timed and precise cell-specific modulation and biomarker-guided patient stratification to improve efficacy and avoid adverse effects.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]