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Second Neoplasms in Italian Patients with Hairy Cell Leukemia after Treatment with Cladribine: AMulticenter Investigation and Literature Review. Cancers 2024, 16, 1475. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers16081475  \nAcademic Editor: Daniel A. Vallera  \nReceived: 7 March 2024  \nRevised: 5 April 2024  \nAccepted: 9 April 2024  \nPublished: 11 April 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy; [marianna.criscuolo@policlinicogemelli.it](marianna.criscuolo@policlinicogemelli.it) (M.C.); [luana.fianchi@policlinicogemelli.it](luana.fianchi@policlinicogemelli.it) (L.F.)  \n2 Istituto Superiore Sanità, 00161 Rome, Italy; mariaelena.tosti@iss.it  \n3 IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”,  \n40138 Bologna, Italy; [alessandro.broccoli6@unibo.it](alessandro.broccoli6@unibo.it) (A.B.); [pierluigi.zinzani@unibo.it](pierluigi.zinzani@unibo.it) (P.L.Z.)  \n4 Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale Università di Bologna,  \n40126 Bologna, Italy  \n5 Divisione di Ematologia, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy; [m.varettoni@smatteo.pv.it](m.varettoni@smatteo.pv.it)  \n6 Oncohematology Division, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy; [alessiomariaedoardo.maraglino@ieo.it](alessiomariaedoardo.maraglino@ieo.it)  \n7 Department of Hematology, ASST Spedali Civili, 25123 Brescia, Italy; [antonella.anastasia@gmail.com](antonella.anastasia@gmail.com)  \n8 Dipartimento di Oncoematologia Policlinico Tor Vergata, Università Tor Vergata, 00133 Rome, Italy; [cantonet@uniroma2.it](cantonet@uniroma2.it)  \n9 Division of Haematology and Clinical Immunology, University of Padova, 35137 Padua, Italy; [livio.trentin@unipd.it](livio.trentin@unipd.it)  \n10 SOD C Ematologia, AOU Careggi, 50134 Firenze, Italy; [to.sofia@mail.ru](to.sofia@mail.ru)  \n[11](11 S.C. Ematologia)[ S.C. Ematologia](11 S.C. Ematologia), [A.O.U. Citt](A.O.U. Citt)à della Salute e della Scienza di Torino, 10126 Turin, Italy; [lorsucci@cittadellasalute.to.it](lorsucci@cittadellasalute.to.it)  \n12 Divisione di Ematologia, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy; [marina.deodato@ospedaleniguarda.it](marina.deodato@ospedaleniguarda.it)  \n13 Dipartimento di Medicina e Chirurgia, Università degli Studi di Parma, 43125 Parma, Italy; [angelica.spolzino@hotmail.it](angelica.spolzino@hotmail.it)  \n14 Oncoematologia, Istituto Oncologico Veneto IOV-IRCSS, 31033 Castelfranco Veneto, Italy  \n15 Clinica Ematologia, Azienda Sanitaria Universitaria Integrata, 33100 Udine, Italy;  \nstefano.volpetti@asuiud.sanita.fvg.it ","cbCaitx2NoA2vDdA","https://ap.wps.com/l/cbCaitx2NoA2vDdA","pdf",247473,"English","# Second Neoplasms After Cladribine Treatment\n## Objectives and Rationale\n## Multicenter Investigation\n## Literature Review","[{\"question\":\"What is the document’s main focus?\",\"answer\":\"It focuses on second neoplasms developing in Italian patients with hairy cell leukemia after cladribine treatment, supported by a multicenter investigation and a literature review.\"},{\"question\":\"Why might second cancers occur after cladribine in these patients?\",\"answer\":\"The document highlights potential roles of immunosuppression, a high cure rate, and aging in the pathogenesis of second cancers after HCL.\"},{\"question\":\"What approach does the study use to evaluate second neoplasms?\",\"answer\":\"It combines data from multiple centers in Italy with an accompanying review of existing literature to contextualize findings and interpretations.\"}]","Second Neoplasms in Italian Patients with Hairy Cell Leukemia after Treatment with Cladribine - A Multicenter Investigation and Literature Review | PDF",1789989146,25]